Cooperative Gsx2-DNA binding requires DNA bending and a novel Gsx2 homeodomain interface.

Autor: Webb JA; Department of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Farrow E; Graduate Program in Molecular and Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, OH 45229, USA.; Medical-Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Cain B; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7007, Cincinnati, OH 45229, USA., Yuan Z; Department of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Yarawsky AE; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA., Schoch E; Department of Medical Education, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Gagliani EK; Department of Chemistry, Xavier University, Cincinnati, OH 45207, USA., Herr AB; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA., Gebelein B; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7007, Cincinnati, OH 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Kovall RA; Department of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Jul 22; Vol. 52 (13), pp. 7987-8002.

A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects.

Autor: Gagliani EK; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America., Gutzwiller LM; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America., Kuang Y; Graduate program in Molecular and Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, United States of America., Odaka Y; Biology Department, University of Cincinnati Blue Ash College, Cincinnati, Ohio, United States of America., Hoffmeister P; University Medical Center Ulm, Center for Internal Medicine, Department of Internal Medicine, Ulm, Germany., Hauff S; University Medical Center Ulm, Center for Internal Medicine, Department of Internal Medicine, Ulm, Germany., Turkiewicz A; Institute of Biochemistry, University of Giessen, Giessen, Germany., Harding-Theobald E; Department of Biology, Dartmouth College, Hanover, New Hampshire, United States of America., Dolph PJ; Department of Biology, Dartmouth College, Hanover, New Hampshire, United States of America., Borggrefe T; Institute of Biochemistry, University of Giessen, Giessen, Germany., Oswald F; University Medical Center Ulm, Center for Internal Medicine, Department of Internal Medicine, Ulm, Germany., Gebelein B; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America., Kovall RA; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2022 Aug 11; Vol. 18 (8), pp. e1010335. Date of Electronic Publication: 2022 Aug 11 (Print Publication: 2022).

PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion.

Autor: Landor SKJ; Faculty of Science and Engineering/Cell Biology, Åbo Akademi University, Turku, Finland; Turku Bioscience, University of Turku and Åbo Akademi University, Turku, Finland., Santio NM; Department of Biology, University of Turku, Turku, Finland., Eccleshall WB; Faculty of Science and Engineering/Cell Biology, Åbo Akademi University, Turku, Finland; Turku Bioscience, University of Turku and Åbo Akademi University, Turku, Finland; Department of Biology, University of Turku, Turku, Finland., Paramonov VM; Faculty of Science and Engineering/Cell Biology, Åbo Akademi University, Turku, Finland; Turku Bioscience, University of Turku and Åbo Akademi University, Turku, Finland; Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland., Gagliani EK; Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Ohio, USA., Hall D; Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Ohio, USA., Jin SB; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden., Dahlström KM; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi, Turku, Finland., Salminen TA; Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi, Turku, Finland., Rivero-Müller A; Faculty of Science and Engineering/Cell Biology, Åbo Akademi University, Turku, Finland; Department of Biology, University of Turku, Turku, Finland., Lendahl U; Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden., Kovall RA; Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Ohio, USA., Koskinen PJ; Department of Biology, University of Turku, Turku, Finland. Electronic address: paivi.koskinen@utu.fi., Sahlgren C; Faculty of Science and Engineering/Cell Biology, Åbo Akademi University, Turku, Finland; Turku Bioscience, University of Turku and Åbo Akademi University, Turku, Finland; Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands. Electronic address: csahlgre@abo.fi.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100593. Date of Electronic Publication: 2021 Mar 26.