Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gaganmeet Singh Chadha"'
Publikováno v:
Open Biology, Vol 11, Iss 10 (2021)
Treslin/Ticrr is required for the initiation of DNA replication and binds to MTBP (Mdm2 Binding Protein). Here, we show that in Xenopus egg extract, MTBP forms an elongated tetramer with Treslin containing two molecules of each protein. Immunodepleti
Externí odkaz:
https://doaj.org/article/7e584a2fa3cf4177b2bad843a1efe827
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2508-2520 (2017)
Dbf4-dependent kinases (DDKs) are required for the initiation of DNA replication, their essential targets being the MCM2-7 proteins. We show that, in Xenopus laevis egg extracts and human cells, hyper-phosphorylation of DNA-bound Mcm4, but not phosph
Externí odkaz:
https://doaj.org/article/490b1fc46b504a26a468772351efb399
Publikováno v:
Open Biology, Vol 4, Iss 1 (2014)
The initiation of DNA replication requires two protein kinases: cyclin-dependent kinase (Cdk) and Cdc7. Although S phase Cdk activity has been intensively studied, relatively little is known about how Cdc7 regulates progression through S phase. We ha
Externí odkaz:
https://doaj.org/article/b4b6775fab8c489199639452ff5020a1
Publikováno v:
Cell Cycle
During S phase, following activation of the S phase CDKs and the DBF4-dependent kinases (DDK), double hexamers of Mcm2-7 at licensed replication origins are activated to form the core replicative helicase. Mcm10 is one of several proteins that have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ab27ee817882cdbaaa097ca31ed43e
http://europepmc.org/articles/PMC4993430
http://europepmc.org/articles/PMC4993430
Autor:
Peter J. Gillespie, J. Julian Blow, Gaganmeet Singh Chadha, Kevin D. Creavin, Julia Neusiedler
Publikováno v:
Methods in Molecular Biology ISBN: 9781493929566
Many important discoveries in cell cycle research have been made using cell-free extracts prepared from the eggs of the South African clawed frog Xenopus laevis. These extracts efficiently support the key nuclear functions of the eukaryotic cell cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5776241cf84236d161eb7404b979d7a1
https://doi.org/10.1007/978-1-4939-2957-3_6
https://doi.org/10.1007/978-1-4939-2957-3_6
Autor:
Peter J, Gillespie, Julia, Neusiedler, Kevin, Creavin, Gaganmeet Singh, Chadha, J Julian, Blow
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1342
Many important discoveries in cell cycle research have been made using cell-free extracts prepared from the eggs of the South African clawed frog Xenopus laevis. These extracts efficiently support the key nuclear functions of the eukaryotic cell cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22501adc603c0cd27287ac352b376f19
https://pubmed.ncbi.nlm.nih.gov/26254920
https://pubmed.ncbi.nlm.nih.gov/26254920
Publikováno v:
DNA Repair
The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a50e3885026c5f0e6e8d8f32b45223f
https://pubmed.ncbi.nlm.nih.gov/24767947
https://pubmed.ncbi.nlm.nih.gov/24767947
Publikováno v:
Open Biology, Vol 4, Iss 1 (2014)
Open Biology
Open Biology
The initiation of DNA replication requires two protein kinases: cyclin-dependent kinase (Cdk) and Cdc7. Although S phase Cdk activity has been intensively studied, relatively little is known about how Cdc7 regulates progression through S phase. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b3c5ff32fe974cc126fee265caa412
https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130138
https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130138
Autor:
Inke S. Näthke, Gaganmeet Singh Chadha, Jason R. Swedlow, Ian P. Newton, Guennadi A. Khoudoli, Angus I. Lamond, Ashwat Visvanathan, Dina Dikovskaya, Daniel M. Klotz
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38102 (2012)
PLoS ONE
PLoS ONE
The tumour suppressor Adenomatous Polyposis Coli (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood. Using demembranated sperm chromatin exposed to meiotic Xenopus egg extract and HeLa cells expressing f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dad71729f22c5a147dafde12480f15
http://europepmc.org/articles/PMC3374815?pdf=render
http://europepmc.org/articles/PMC3374815?pdf=render
Autor:
J. Julian Blow, Gaganmeet Singh Chadha
Publikováno v:
Molecular Cell. 37(1):5-6
In this issue of Molecular Cell, Miotto and Struhl (2010) suggest that replication licensing, the loading of Mcm2-7 onto DNA, is promoted by HBO1 acetylating histone H4 at replication origins, providing a molecular view of how chromatin status influe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd1ac047f8f21c52b3b3dff9d2673af