Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes

Autor: Alves, Marco L., Gaffin, Robert D., Wolska, Beata M.

Publikováno v: In Journal of Molecular and Cellular Cardiology May 2010 48(5):834-842

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Arginine–glycine–aspartic acid (RGD)-containing peptides inhibit the force production of mouse papillary muscle bundles via α5β1 integrin

Autor: Sarin, Vandana, Gaffin, Robert D, Meininger, Gerald A, Muthuchamy, Mariappan

Integrins are considered to be an important mechanosensor in cardiac myocytes. To test whether integrins can influence cardiac contractile function, the force-frequency relationships of mouse papillary muscle bundles were measured in the presence or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7c0534fc6c079a7ad01b32642999273
https://europepmc.org/articles/PMC1464440/

Roles of phosphorylation of myosin binding protein-C and troponin I in mouse cardiac muscle twitch dynamics

Autor: Tong, Carl W, Gaffin, Robert D, Zawieja, David C, Muthuchamy, Mariappan

A normal heart increases its contractile force with increasing heart rate. Although calcium handling and myofibrillar proteins have been implicated in maintaining this positive force-frequency relationship (FFR), the exact mechanisms by which it occu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f52d5da23b1371d9f5d9886bf919be30
https://europepmc.org/articles/PMC1665013/

Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics.

Autor: Gaffin, Robert D., Gokulan, Kuppan, Sacchettini, James C., Hewett, Timothy E., Klevitsky, Raisa, Robbins, Jeffrey, Sarin, Vandana, Zawieja, David C., Meininger, Gerald A., Muthuchamy, Mariappan

Publikováno v: American Journal of Physiology: Heart & Circulatory Physiology; Aug2006, Vol. 291 Issue 2, pH552-H563, 12p, 2 Diagrams, 2 Charts, 2 Graphs