The impact of ageing on the human haematopoietic stem cell and memory T cell compartments through the lens of single cell transcriptome analysis

Autor: Gafencu, GA

Human biological ageing comprises the molecular and physiological changes that negatively affect homeostasis with age and are strongly associated with susceptibility to disease and ultimately death. This thesis utilises single cell transcriptomics to

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Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.

Autor: Jakobsen NA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, UK., Turkalj S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, UK., Zeng AGX; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Stoilova B; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Metzner M; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Rahmig S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Nagree MS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Shah S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Moore R; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Usukhbayar B; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Angulo Salazar M; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Gafencu GA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Kennedy A; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Newman S; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Kendrick BJL; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Taylor AH; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Afinowi-Luitz R; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Gundle R; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Watkins B; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Wheway K; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Beazley D; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Murison A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Aguilar-Navarro AG; Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Flores-Figueroa E; Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Dakin SG; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Carr AJ; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Nerlov C; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Dick JE; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Xie SZ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Vyas P; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, UK; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address: paresh.vyas@imm.ox.ac.uk.

Publikováno v: Cell stem cell [Cell Stem Cell] 2024 Aug 01; Vol. 31 (8), pp. 1127-1144.e17. Date of Electronic Publication: 2024 Jun 24.

PARP inhibitors in acute myeloid leukaemia therapy: How a synthetic lethality approach can be a valid therapeutic alternative.

Autor: Gafencu GA; Research Center for Functional Genomics, Biomedicine and Translational Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania. Electronic address: grigore.gafencu@student.umfcluj.ro., Tomuleasa CI; Research Center for Functional Genomics, Biomedicine and Translational Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania., Ghiaur G; Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University, Baltimore, MD, USA.

Publikováno v: Medical hypotheses [Med Hypotheses] 2017 Jul; Vol. 104, pp. 30-34. Date of Electronic Publication: 2017 May 22.

Clinicopathological analysis of a case series of peripheral T-cell lymphomas, not otherwise specified, of lymphoepithelioid variant (Lennert's lymphoma). A Central European single-center study.

Autor: Gafencu GA; Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania., Selicean SE; Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania., Petrushev B; Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania., Cucuianu A; Department of Hematology, Ion Chiricuță Oncology Institute, Cluj Napoca, Romania., Dima D; Department of Hematology, Ion Chiricuță Oncology Institute, Cluj Napoca, Romania., Frinc I; Department of Hematology, Ion Chiricuță Oncology Institute, Cluj Napoca, Romania., Irimie A; Department of Surgery, Ion Chiricuță Oncology Institute, Cluj Napoca, Romania., Pileczki V; Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Berindan-Neagoe I; Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Berce C; Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania., Buiga R; Department of Pathology, Ion Chiricuță Oncology Institute, Cluj Napoca, Romania., Tomuleasa C; Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania; Department of Hematology, Ion Chiricuță Oncology Institute, Cluj Napoca, Romania. Electronic address: ciprian.tomuleasa@gmail.com.

Publikováno v: Human pathology [Hum Pathol] 2016 Jul; Vol. 53, pp. 192-4. Date of Electronic Publication: 2016 Mar 23.

MicroRNAs in liver malignancies. Basic science applied in surgery.

Autor: Muresan M; Department of Surgery, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania., Zaharie F, Bojan A, Frinc I, Dima D, Selicean S, Gafencu GA, Petrushev B, Cojocneanu-Petric R, Tefas C, Cioca A, Irimie A, Berce C, Berindan-Neagoe I, Tomuleasa C, Achimas-Cadariu P

Publikováno v: Journal of B.U.ON. : official journal of the Balkan Union of Oncology [J BUON] 2015 Mar-Apr; Vol. 20 (2), pp. 361-75.