Large-pore connexin hemichannels function like molecule transporters independent of ion conduction.

Autor: Gaete PS; Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616., Kumar D; Department of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766., Fernandez CI; Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616., Valdez Capuccino JM; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103., Bhatt A; Department of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766., Jiang W; Department of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766., Lin YC; Department of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766., Liu Y; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103., Harris AL; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103., Luo YL; Department of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766., Contreras JE; Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA 95616.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 13; Vol. 121 (33), pp. e2403903121. Date of Electronic Publication: 2024 Aug 08.

Two Toxoplasma gondii putative pore-forming proteins, GRA47 and GRA72, influence small molecule permeability of the parasitophorous vacuole.

Autor: Bitew MA; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA., Gaete PS; Department of Physiology and Membrane Biology, University of California, Davis, California, USA., Swale C; Team Host-Pathogen Interactions and Immunity to Infection, Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France., Maru P; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA., Contreras JE; Department of Physiology and Membrane Biology, University of California, Davis, California, USA., Saeij JPJ; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA.

Publikováno v: MBio [mBio] 2024 Mar 13; Vol. 15 (3), pp. e0308123. Date of Electronic Publication: 2024 Feb 21.

Connexin and Pannexin Large-Pore Channels in Microcirculation and Neurovascular Coupling Function.

Autor: Burboa PC; Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, 185 South Orange Avenue, Newark, NJ 07103, USA.; Departamento de Morfología y Función, Facultad de Salud y Ciencias Sociales, Sede Santiago Centro, Universidad de las Américas, Avenue República 71, Santiago 8370040, Chile., Puebla M; Departamento de Morfología y Función, Facultad de Salud y Ciencias Sociales, Sede Santiago Centro, Universidad de las Américas, Avenue República 71, Santiago 8370040, Chile., Gaete PS; Department of Physiology and Membrane Biology, University of California at Davis, Davis, CA 95616, USA., Durán WN; Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, 185 South Orange Avenue, Newark, NJ 07103, USA.; Rutgers School of Graduate Studies, 185 South Orange Avenue, Newark, NJ 07103, USA., Lillo MA; Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, 185 South Orange Avenue, Newark, NJ 07103, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 30; Vol. 23 (13). Date of Electronic Publication: 2022 Jun 30.

ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels.

Autor: Narahari AK; Department of Pharmacology, University of Virginia, Charlottesville, United States., Kreutzberger AJ; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States., Gaete PS; Department of Pharmacology, Physiology, and Neuroscience, Rutgers New Jersey Medical School, Newark, United States., Chiu YH; Department of Pharmacology, University of Virginia, Charlottesville, United States., Leonhardt SA; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States., Medina CB; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, United States., Jin X; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States., Oleniacz PW; Department of Pharmacology, University of Virginia, Charlottesville, United States., Kiessling V; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States., Barrett PQ; Department of Pharmacology, University of Virginia, Charlottesville, United States., Ravichandran KS; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, United States., Yeager M; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States., Contreras JE; Department of Pharmacology, Physiology, and Neuroscience, Rutgers New Jersey Medical School, Newark, United States., Tamm LK; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, United States., Bayliss DA; Department of Pharmacology, University of Virginia, Charlottesville, United States.

Publikováno v: ELife [Elife] 2021 Jan 07; Vol. 10. Date of Electronic Publication: 2021 Jan 07.

A novel voltage-clamp/dye uptake assay reveals saturable transport of molecules through CALHM1 and connexin channels.

Autor: Gaete PS; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ., Lillo MA; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ., López W; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ., Liu Y; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ., Jiang W; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA., Luo Y; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA., Harris AL; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ., Contreras JE; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ.

Publikováno v: The Journal of general physiology [J Gen Physiol] 2020 Nov 02; Vol. 152 (11).