Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gaetano Speciale"'
Autor:
Rebekah P. Dyer, Hariny M. Isoda, Gabriela S. Salcedo, Gaetano Speciale, Madison H. Fletcher, Linh Q. Le, Yi Liu, Karen Brami-Cherrier, Shiazah Z. Malik, Edwin J. Vazquez-Cintron, Andrew C. Chu, David C. Rupp, Birgitte P. S. Jacky, Thu T. M. Nguyen, Benjamin B. Katz, Lance E. Steward, Sudipta Majumdar, Amy D. Brideau-Andersen, Gregory A. Weiss
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The botulinum neurotoxin serotype A (BoNT/A) cuts a single peptide bond in SNAP25, an activity used to treat a wide range of diseases. Reengineering the substrate specificity of BoNT/A’s protease domain (LC/A) could expand its therapeutic
Externí odkaz:
https://doaj.org/article/1faa403f9c0b49ad85a29291d7a72970
Autor:
Lukasz F. Sobala, Gaetano Speciale, Sha Zhu, Lluı́s Raich, Natalia Sannikova, Andrew J. Thompson, Zalihe Hakki, Dan Lu, Saeideh Shamsi Kazem Abadi, Andrew R. Lewis, Vı́ctor Rojas-Cervellera, Ganeko Bernardo-Seisdedos, Yongmin Zhang, Oscar Millet, Jesús Jiménez-Barbero, Andrew J. Bennet, Matthieu Sollogoub, Carme Rovira, Gideon J. Davies, Spencer J. Williams
Publikováno v:
ACS Central Science, Vol 6, Iss 5, Pp 760-770 (2020)
Externí odkaz:
https://doaj.org/article/74e7b245be3a4006a0bd9ec45aa0acd6
Publikováno v:
Molecules, Vol 18, Iss 8, Pp 8779-8785 (2013)
Adenosine diphosphate ribosylation (ADP-ribosylation) is a widely occurring post-translational modification of proteins at nucleophilic side chain of amino acid residues. Elucidation of ADP-ribosylation events would benefit greatly from the availabil
Externí odkaz:
https://doaj.org/article/3e16941920714423937157483a46b112
Autor:
Micah Malik Lawrence, Sanjana Sen, Elliot L. Botvinick, Sudipta Majumdar, Danielle Myra Behrens, Gregory A. Weiss, Jessica Ngoc-Han Pham, Dat Nguyen, Gaetano Speciale, Avid Najdahmadi
Publikováno v:
Anal Chem
Molecular sensors from protein engineering offer new methods to sensitively bind to and detect target analytes for a wide range of applications. For example, these sensors can be integrated into probes for implantation, and then yield new and valuabl
Autor:
Gregory A. Weiss, Aisha Attar, Reginald M. Penner, Gaetano Speciale, Mark B. Richardson, Rebekah P. Dyer, Emily C Sanders, Sudipta Majumdar
Publikováno v:
ACS Applied Materials & Interfaces. 11:4757-4765
A polymer-based electrode capable of specific detection of human serum albumin, and its glycated derivatives, is described. The sensor is constructed from a glass microscope slide coated with a synthesized, polythiophene film bearing a protected, imi
Publikováno v:
Organic & Biomolecular Chemistry. 17:7863-7869
Enzyme transition-state mimics can act as powerful inhibitors and allow structural studies that report on the conformation of the transition-state. Here, mannoimidazole, a mimic of the transition state of mannosidase catalyzed hydrolysis of mannoside
Autor:
Andrew Chu, Birgitte P.S. Jacky, Yi Liu, Thu T.M. Nguyen, Gabriela S. Salcedo, David C. Rupp, Madison H. Fletcher, Amy Brideau-Andersen, Edwin J. Vazquez-Cintron, Hariny M. Isoda, Sudipta Majumdar, Gregory A. Weiss, Linh Q. Le, Shiazah Z. Malik, Rebekah P. Dyer, Gaetano Speciale, Lance E. Steward
The botulinum neurotoxin serotype A (BoNT/A) cuts a single peptide bond in SNAP25, an activity used to treat a wide range of diseases. Reengineering the substrate specificity of BoNT/A’s protease domain (LC/A) could expand its therapeutic applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6144568fd977c759204c6635d27ec4c
https://doi.org/10.1101/2020.09.29.319145
https://doi.org/10.1101/2020.09.29.319145
Publikováno v:
Journal of the American Society for Mass Spectrometry. 28:1425-1431
A suite of isotopologues of methyl D-glucopyranosides is used in conjunction with multistage mass spectrometry experiments to determine the radical site and cleavage reactions of sugar radical cations formed via a recently developed 'bio-inspired' me
Autor:
Fiona Cuskin, Max J. Temple, Elisabeth C. Lowe, Niall A. Hickey, Spencer J. Williams, Arnaud Baslé, Harry J. Gilbert, Gaetano Speciale
Publikováno v:
The Journal of Biological Chemistry
Glycans are major nutrients available to the human gut microbiota. The Bacteroides are generalist glycan degraders, and this function is mediated largely by polysaccharide utilization loci (PULs). The genomes of several Bacteroides species contain a
Autor:
Andrew J. Bennet, Fahimeh S. Shidmoossavee, Marco Farren-Dai, Spencer J. Williams, Gaetano Speciale
Publikováno v:
Journal of the American Chemical Society. 138:14012-14019
The hydroxide-catalyzed hydrolysis of aryl 1,2-trans-glycosides proceeds through a mechanism involving neighboring group participation by a C2-oxyanion and rate-limiting formation of a 1,2-anhydro sugar (oxirane) intermediate. The transition state fo