Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gaetano Faleo"'
Autor:
Gauree S. Chendke, Bhushan N. Kharbikar, Sudipta Ashe, Gaetano Faleo, Julie B. Sneddon, Qizhi Tang, Matthias Hebrok, Tejal A. Desai
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 4, Pp n/a-n/a (2023)
Abstract Beta cell replacement therapy (BCRT) for patients with type 1 diabetes (T1D) improves blood glucose regulation by replenishing the endogenous beta cells destroyed by autoimmune attack. Several limitations, including immune isolation, prevent
Externí odkaz:
https://doaj.org/article/bdf451e523a94e80a96f8c5a8407ba68
Autor:
Yannick D. Muller, Leonardo M. R. Ferreira, Emilie Ronin, Patrick Ho, Vinh Nguyen, Gaetano Faleo, Yu Zhou, Karim Lee, Kevin K. Leung, Nikolaos Skartsis, Anupurna M. Kaul, Arend Mulder, Frans H. J. Claas, James A. Wells, Jeffrey A. Bluestone, Qizhi Tang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Infusion of regulatory T cells (Tregs) engineered with a chimeric antigen receptor (CAR) targeting donor-derived human leukocyte antigen (HLA) is a promising strategy to promote transplant tolerance. Here, we describe an anti-HLA-A2 CAR (A2-CAR) gene
Externí odkaz:
https://doaj.org/article/0e55594766a242cca34a7e2ce34bf567
Autor:
Gaetano Faleo, Holger A. Russ, Steven Wisel, Audrey V. Parent, Vinh Nguyen, Gopika G. Nair, Jonathan E. Freise, Karina E. Villanueva, Gregory L. Szot, Matthias Hebrok, Qizhi Tang
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 807-819 (2017)
The advent of large-scale in vitro differentiation of human stem cell-derived insulin-producing cells (SCIPC) has brought us closer to treating diabetes using stem cell technology. However, decades of experiences from islet transplantation show that
Externí odkaz:
https://doaj.org/article/8c80ae30ac8e46c1ad72b1bc6fbd64f5
Autor:
Peter Buchwald, Antonello Pileggi, Camillo Ricordi, Per Olof Berggren, Gaetano Faleo, Ashley Tschiggfrie, R. Damaris Molano, Virginia R. Aldrich, Luis F. Hernandez, Ulisse Ulissi, Carmen Fotino, Allison S. Bayer, Alexander Shishido, Alejandro Tamayo-Garcia, Maite Lopez-Cabezas, Midhat H. Abdulreda, Alejandro Caicedo
Publikováno v:
Diabetologia
AIMS/HYPOTHESIS: Autoimmune attack against the insulin-producing beta cells in the pancreatic islets results in type 1 diabetes. However, despite considerable research, details of the type 1 diabetes immunopathology in situ are not fully understood m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be3a97d4c17d574ed0148f6c474432a
https://doi.org/10.1007/s00125-019-4879-0
https://doi.org/10.1007/s00125-019-4879-0
Autor:
Qizhi Tang, Matthias Hebrok, Audrey Parent, David I. Berrios, Natanya R. Kerper, Michael S Saxton, Gaetano Faleo, Jessica Chavez
Publikováno v:
Cell reports. 36(7)
Summary Stem cell-based replacement therapies hold the promise to restore function of damaged or degenerated tissue such as the pancreatic islets in people with type 1 diabetes. Wide application of these therapies requires overcoming the fundamental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68053586a59eff2ffcc39ca8f271b79c
https://pubmed.ncbi.nlm.nih.gov/34407395
https://pubmed.ncbi.nlm.nih.gov/34407395
Autor:
Holger A. Russ, Audrey Parent, Gregory L. Szot, Jonathan Freise, Karina E. Villanueva, Vinh Son Nguyen, Qizhi Tang, Matthias Hebrok, Steven A. Wisel, Gaetano Faleo, Gopika G. Nair
Publikováno v:
Stem cell reports, vol 9, iss 3
Stem Cell Reports, Vol 9, Iss 3, Pp 807-819 (2017)
Stem Cell Reports
Stem Cell Reports, Vol 9, Iss 3, Pp 807-819 (2017)
Stem Cell Reports
Summary The advent of large-scale in vitro differentiation of human stem cell-derived insulin-producing cells (SCIPC) has brought us closer to treating diabetes using stem cell technology. However, decades of experiences from islet transplantation sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6d2dd5f637de7b9705dc3971eceb05
https://doi.org/10.1016/j.stemcr.2017.07.012
https://doi.org/10.1016/j.stemcr.2017.07.012
Autor:
Audrey Parent, Matthias Hebrok, Holger A. Russ, Tejal A. Desai, Susanna K. Elledge, Qizhi Tang, Jessica L. Allen, Daniel A. Bernards, Gaetano Faleo, Ryan Chang, Karina E. Villanueva
Publikováno v:
ACS nano, vol 11, iss 8
Encapsulation of human embryonic stem-cell-differentiated beta cell clusters (hES-βC) holds great promise for cell replacement therapy for the treatment of diabetics without the need for chronic systemic immune suppression. Here, we demonstrate a na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48479345ca3cf2475429de1753c48c8
https://doi.org/10.1021/acsnano.7b01239
https://doi.org/10.1021/acsnano.7b01239
Autor:
Gaetano Faleo, Matthias Hebrok, Tejal A. Desai, Qizhi Tang, Audrey Parent, Gauree S. Chendke, Charity Juang, Daniel A. Bernards
Publikováno v:
Advanced biosystems, vol 3, iss 9
Pancreatic islet transplantation is a promising treatment for type I diabetes, which is a chronic autoimmune disease in which the host immune cells attack insulin-producing beta cells. The impact of this therapy is limited due to tissue availability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb360fc25bd24c248fa7999bc100a22e
https://europepmc.org/articles/PMC6800235/
https://europepmc.org/articles/PMC6800235/
Autor:
Gaetano Faleo, Kevin D. Lance, Qizhi Tang, Daniel A. Bernards, Ryan Chang, Crystal E. Nyitray, Tejal A. Desai
Publikováno v:
ACS nano, vol 9, iss 6
Cell-encapsulating devices can play an important role in advancing the types of tissue available for transplantation and further improving transplant success rates. To have an effective device, encapsulated cells must remain viable, respond to extern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6b01e842e7665b4cba45c298b10345
https://doi.org/10.1021/acsnano.5b00679
https://doi.org/10.1021/acsnano.5b00679
Autor:
Casey Ward, Wenhan Chang, Peter G. Stock, Qizhi Tang, Quan Duh, Gaetano Faleo, Hebrok Mathias
Publikováno v:
Transplantation. 102:S368-S369
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a575c6005c40e9e5a54f54e61e3b8083
https://doi.org/10.1097/01.tp.0000543120.88749.0f
https://doi.org/10.1097/01.tp.0000543120.88749.0f