Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Gaetano Cairo"'
Publikováno v:
Metabolites, Vol 14, Iss 4, p 228 (2024)
Iron is an essential nutrient for growth among all branches of life, but while iron is among the most common elements, bioavailable iron is a relatively scarce nutrient. Since iron is fundamental for several biological processes, iron deficiency can
Externí odkaz:
https://doaj.org/article/fb603527c767437b8b211c87f61d8d5b
Autor:
Gaetano Cairo, Benoit Champigneulle, Margherita Correnti, Elena Gammella, Stefania Recalcati, Domenico Girelli, Annalisa Castagna, Anne-Kristine Meinild Lundby, Ivan Hancco, Carole Chirica, Dorra Guergour, Laura Oberholzer, Emeric Stauffer, Carsten Lundby, Aurélien Pichon, Julien V Brugniaux, Stéphane Doutreleau, Samuel Verges, Paul Robach
Publikováno v:
HemaSphere, Vol 7, Iss 3, p e849 (2023)
Externí odkaz:
https://doaj.org/article/88c014251a86413c83fc5b72bb48660c
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5341 (2022)
Iron is necessary for essential processes in every cell of the body, but the erythropoietic compartment is a privileged iron consumer. In fact, as a necessary component of hemoglobin and myoglobin, iron assures oxygen distribution; therefore, a consi
Externí odkaz:
https://doaj.org/article/18e842259b4744f3a74e42096c6761a5
Autor:
Paul Robach, Elena Gammella, Stefania Recalcati, Domenico Girelli, Annalisa Castagna, Matthieu Roustit, Carsten Lundby, Anne-Kristine Lundby, Pierre Bouzat, Samuel Vergès, Guillaume Séchaud, Pierluigi Banco, Mario Uhr, Catherine Cornu, Pierre Sallet, Gaetano Cairo
Publikováno v:
Haematologica, Vol 106, Iss 2 (2020)
The erythropoietin (Epo)-erythroferrone (ERFE)-hepcidin axis coordinates erythropoiesis and iron homeostasis. While mouse studies have established that Epo-induced ERFE production represses hepcidin synthesis by inhibiting hepatic BMP/SMAD signaling,
Externí odkaz:
https://doaj.org/article/36153f5eaee649968fe23704a360288e
Autor:
Stefania Recalcati, Gaetano Cairo
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1585 (2021)
Macrophages perform a variety of different biological functions and are known for their essential role in the immune response. In this context, a principal function is phagocytic clearance of pathogens, apoptotic and senescent cells. However, the maj
Externí odkaz:
https://doaj.org/article/bf8ccefc79894de88786667684f97b70
Autor:
Stefania Recalcati, Margherita Correnti, Elena Gammella, Chiara Raggi, Pietro Invernizzi, Gaetano Cairo
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Cancer stem cells (CSC) which have been identified in several tumors, including liver cancer, represent a particular subpopulation of tumor cells characterized by properties similar to those of adult stem cells. Importantly, CSC are resistant to stan
Externí odkaz:
https://doaj.org/article/cc5daa971ccb41ee883e8448aa67c1c0
Autor:
Stefania Recalcati, Elena Gammella, Paolo Buratti, Andrea Doni, Achille Anselmo, Massimo Locati, Gaetano Cairo
Publikováno v:
Haematologica, Vol 104, Iss 1 (2019)
Iron recycling by macrophages is essential for erythropoiesis, but may also be relevant for iron redistribution to neighboring cells at the local tissue level. Using mice with iron retention in macrophages due to targeted inactivation of the iron exp
Externí odkaz:
https://doaj.org/article/40610bee136a4ee08d9edac45fe10501
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2986 (2021)
Body iron levels are regulated by hepcidin, a liver-derived peptide that exerts its function by controlling the presence of ferroportin (FPN), the sole cellular iron exporter, on the cell surface. Hepcidin binding leads to FPN internalization and deg
Externí odkaz:
https://doaj.org/article/8fed53a2852743ad8ac5d32518f3199a
Publikováno v:
Pharmaceuticals, Vol 12, Iss 2, p 94 (2019)
Over the last decade, increasing evidence has reinforced the key role of metabolic reprogramming in macrophage activation. In addition to supporting the specific immune response of different subsets of macrophages, intracellular metabolic pathways al
Externí odkaz:
https://doaj.org/article/47eda497c9b843f0ae099fb21656457c
Autor:
Paola Dongiovanni, Claudia Lanti, Stefano Gatti, Raffaela Rametta, Stefania Recalcati, Marco Maggioni, Anna Ludovica Fracanzani, Patrizia Riso, Gaetano Cairo, Silvia Fargion, Luca Valenti
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116855 (2015)
Increased serum ferritin associated with mild hepatic iron accumulation, despite preserved upregulation of the iron hormone hepcidin, is frequently observed in patients with dysmetabolic overload syndrome (DIOS). Genetic factors and Western diet repr
Externí odkaz:
https://doaj.org/article/f4825baf40b440f096301fa50da4e4fa