Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gaelle Saintigny"'
Publikováno v:
European Journal of Dermatology, 27(3), 237-246
Papillary and reticular fibroblasts have different effects on keratinocyte proliferation and differentiation. The aim of this study was to investigate whether these effects are caused by differential secretion of soluble factors or by differential ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711051fb6403fefe6a095dfccb801900
https://hdl.handle.net/1887/115804
https://hdl.handle.net/1887/115804
Publikováno v:
European Journal of Dermatology, 24(3), 342-348
Fibroblasts isolated from the papillary and reticular dermis are different from each other in vitro. If papillary fibroblasts are subjected to prolonged serial passaging they will differentiate into reticular fibroblasts. Reticular fibroblasts have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6d30ef7b6de9c23ef0c7329131c405
https://doi.org/10.1684/ejd.2014.2312
https://doi.org/10.1684/ejd.2014.2312
Autor:
Eleonora Candi, Christian Mahé, Gaelle Saintigny, Mara Mancini, Gerry Melino, Margherita Annicchiarico-Petruzzelli
Publikováno v:
Aging (Albany NY)
Scopus-Elsevier
Scopus-Elsevier
Ageing of human skin is associated with phenotypic changes in the cutaneous cells; the major functional markers of ageing occur as consequences of dermal and epidermal cell senescence and of structural and compositional remodeling of normally long-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60e8adf934e74cdc5fef8277bba5986
http://europepmc.org/articles/PMC3560438
http://europepmc.org/articles/PMC3560438
Autor:
Gaelle Saintigny, P. Rivetti di Val Cervo, Mara Mancini, Anna Maria Lena, E Candi, Christian Mahé, Gerry Melino
Publikováno v:
Biochemical and Biophysical Research Communications
Highlights ► miR-191 expression is upregulated in senescencent human epidermal keratinocytes. ► miR-191 overexpression is sufficient per se to induce senescence in keratinocytes. ► SATB1 and CDK6 are downregulated in senescence and are direct m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa18ab084e419f6e10d5c2a5aaf34a91
Human Skin Aging Is Associated with Reduced Expression of the Stem Cell Markers β1 Integrin and MCSP
Publikováno v:
Journal of Investigative Dermatology. 130:604-608
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e15e4a780bfcc3b53c1eea1b51dc10a
https://doi.org/10.1038/jid.2009.297
https://doi.org/10.1038/jid.2009.297
Autor:
Anna Maria Lena, Massimiliano Agostini, Gaelle Saintigny, Giuditta Viticchiè, Mara Mancini, David Dinsdale, Eleonora Candi, Huiqing Zhou, Lello Zolla, Gerry Melino
Publikováno v:
Proceedings of the National Academy of Sciences USA, 112, 11577-82
Proceedings of the National Academy of Sciences USA, 112, 37, pp. 11577-82
Proceedings of the National Academy of Sciences USA, 112, 37, pp. 11577-82
Short p63 isoform, ΔNp63, is crucial for epidermis formation, and it plays a pivotal role in controlling the turnover of basal keratinocytes by regulating the expression of a subset of genes involved in cell cycle and cell adhesion programs. The gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33116cf55828c9ccbca780750cea2df0
http://hdl.handle.net/2108/153167
http://hdl.handle.net/2108/153167
Autor:
Anna Maria Lena, Nicola Di Daniele, Mara Mancini, Gerry Melino, Gaelle Saintigny, Christian Mahé, Eleonora Candi
The skin protects humans from the surrounding environment. Tissues undergo continuous renewal throughout an individual's lifetime; however, there is a decline in the regenerative potential of tissue with age. The accumulation of senescent cells over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70464a2d27547ad21f0a9142515045f6
http://hdl.handle.net/2108/132091
http://hdl.handle.net/2108/132091
Publikováno v:
Experimental Dermatology, 22(1), 48-53
The dermis can be divided into two morphologically different layers: the papillary and reticular dermis. Fibroblasts isolated from these layers behave differently when cultured in vitro. During skin ageing, the papillary dermis decreases in volume. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5acff3f64bbb380a361ffc37883e400
http://hdl.handle.net/1887/118906
http://hdl.handle.net/1887/118906
The dermis contains two distinct layers: the papillary and the reticular layers. In vitro cultures of the fibroblasts from these layers show that they are different. However, no molecular markers to differentiate between the two subtypes of fibroblas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07084f750633959b0c831894ace5a6b
https://hdl.handle.net/1887/118907
https://hdl.handle.net/1887/118907
Autor:
Gennaro Melino, Simona Rossi, Elena Dellambra, Eleonora Candi, Christian Mahé, George A. Calin, Huiqing Zhou, Mara Mancini, Anna Maria Lena, Pia Rivetti di Val Cervo, Gaelle Saintigny, Milena S. Nicoloso, Teresa Odorisio
Publikováno v:
Proceedings of the National Academy of Sciences USA, 109, 1133-1138
Proceedings of the National Academy of Sciences USA, 109, 4, pp. 1133-1138
Proceedings of the National Academy of Sciences USA, 109, 4, pp. 1133-1138
We investigated the expression of microRNAs (miRNAs) associated with replicative senescence in human primary keratinocytes. A cohort of miRNAs up-regulated in senescence was identified by genome-wide miRNA profiling, and their change in expression wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aace75cf76fec00960ccdb9cbc4e230a
http://hdl.handle.net/2108/78136
http://hdl.handle.net/2108/78136