Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gaelle Legube"'
Autor:
Matteo Mazzocca, Alessia Loffreda, Emanuele Colombo, Tom Fillot, Daniela Gnani, Paola Falletta, Emanuele Monteleone, Serena Capozi, Edouard Bertrand, Gaelle Legube, Zeno Lavagnino, Carlo Tacchetti, Davide Mazza
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization in such search is uncharted. Here we analyzed how multiple factors explore chromatin, combining live-cell single-molecule tracking with multifoca
Externí odkaz:
https://doaj.org/article/ad0df2d97361490abffab1918d47a1fd
Autor:
Matteo Mazzocca, Alessia Loffreda, Emanuele Colombo, Tom Fillot, Daniela Gnani, Paola Falletta, Emanuele Monteleone, Serena Capozi, Edouard Bertrand, Gaelle Legube, Zeno Lavagnino, Carlo Tacchetti, Davide Mazza
Nuclear Factors (NFs) rapidly scan the genome for their targets, but the role of nuclear organization in such search is unexplored. To address this, we combined live-cell single-molecule tracking of NFs with multifocal structured illumination of DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0093f48892d2ca2121ee7e62fd77718
https://doi.org/10.1101/2022.12.29.522193
https://doi.org/10.1101/2022.12.29.522193
Autor:
Ilaria Gritti, Veronica Basso, Darawan Rinchai, Federica Corigliano, Silvia Pivetti, Marco Gaviraghi, Dalia Rosano, Davide Mazza, Sara Barozzi, Marco Roncador, Giovanni Parmigiani, Gaelle Legube, Dario Parazzoli, Davide Cittaro, Davide Bedognetti, Anna Mondino, Simona Segalla, Giovanni Tonon
Publikováno v:
The EMBO Journal. 41
The ribonuclease DIS3 is one of the most frequently mutated genes in the hematological cancer multiple myeloma, yet the basis of its tumor suppressor function in this disease remains unclear. Herein, exploiting the TCGA dataset, we found that DIS3 pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ec165921c6e11690f71fa8de829944
https://doi.org/10.15252/embj.2021108040
https://doi.org/10.15252/embj.2021108040
Autor:
Jean Personnaz, Enzo Piccolo, Alizée Dortignac, Jason S. Iacovoni, Jérôme Mariette, Vincent Rocher, Arnaud Polizzi, Aurélie Batut, Simon Deleruyelle, Lucas Bourdens, Océane Delos, Lucie Combes-Soia, Romain Paccoud, Elsa Moreau, Frédéric Martins, Thomas Clouaire, Fadila Benhamed, Alexandra Montagner, Walter Wahli, Robert F. Schwabe, Armelle Yart, Isabelle Castan-Laurell, Justine Bertrand-Michel, Odile Burlet-Schiltz, Catherine Postic, Pierre-Damien Denechaud, Cédric Moro, Gaelle Legube, Chih-Hao Lee, Hervé Guillou, Philippe Valet, Cédric Dray, Jean-Philippe Pradère
Publikováno v:
Science Advances
Science Advances, 2022, 8 (12), ⟨10.1126/sciadv.abg9055⟩
Science Advances, 2022, 8 (12), ⟨10.1126/sciadv.abg9055⟩
Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as nonalcoholic fatty liver diseases (NAFLDs). Molecular mechanisms underlying liver lipogenesis are very comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79eac556bb1af4b744201d38bffcecbf
https://hal.inrae.fr/hal-03624265/document
https://hal.inrae.fr/hal-03624265/document
Autor:
Matthew James, Bottomley, Gunter, Stier, Danilo, Pennacchini, Gaelle, Legube, Bernd, Simon, Asifa, Akhtar, Michael, Sattler, Giovanna, Musco
Publikováno v:
The Journal of biological chemistry. 280(12)
Mutations in the autoimmune regulator protein AIRE1 cause a monogenic autosomal recessively inherited disease: autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). AIRE1 is a multidomain protein that harbors two plant homeodomain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f00de35b6f088359eab49d4d99516cd
https://pubmed.ncbi.nlm.nih.gov/15649886
https://pubmed.ncbi.nlm.nih.gov/15649886
Autor:
Philippe E. Mangeot, Valérie Risson, Floriane Fusil, Aline Marnef, Emilie Laurent, Juliana Blin, Virginie Mournetas, Emmanuelle Massouridès, Thibault J. M. Sohier, Antoine Corbin, Fabien Aubé, Marie Teixeira, Christian Pinset, Laurent Schaeffer, Gaëlle Legube, François-Loïc Cosset, Els Verhoeyen, Théophile Ohlmann, Emiliano P. Ricci
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
A current challenge in genome editing is delivering Cas9 and sgRNA into target cells. Here the authors engineer a delivery system based on murine leukemia virus-like particles loaded with Cas9-sgRNA ribonucleoproteins to induce efficient genome editi
Externí odkaz:
https://doaj.org/article/0bd13889c5db4e0ba26c33892287ae45
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead
Externí odkaz:
https://doaj.org/article/f80b5fb8431a48af955ae03d4fdc956d
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Double-strand breaks (DSBs) result from the attack of both DNA strands by multiple sources, including radiation and chemicals. DSBs can cause the abnormal chromosomal rearrangements associated with cancer. Recent techniques allow the genome-
Externí odkaz:
https://doaj.org/article/b891b4d1e9d6447f9800a4e522a0dfcd
Autor:
Sarah Cohen, Nadine Puget, Yea-Lih Lin, Thomas Clouaire, Marion Aguirrebengoa, Vincent Rocher, Philippe Pasero, Yvan Canitrot, Gaëlle Legube
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Recent studies suggest key roles of RNA in DNA double-strand breaks repair. Here the authors identify the helicase senataxin to be involved in DNA repair and resolve RNA:DNA hybrids forming at DNA double-strand breaks.
Externí odkaz:
https://doaj.org/article/a76ef802a4c44fb2b9db439a268bff73
Autor:
Pierre Caron, Jonathan Choudjaye, Thomas Clouaire, Béatrix Bugler, Virginie Daburon, Marion Aguirrebengoa, Thomas Mangeat, Jason S. Iacovoni, Alejandro Álvarez-Quilón, Felipe Cortés-Ledesma, Gaëlle Legube
Publikováno v:
Cell Reports, Vol 13, Iss 8, Pp 1598-1609 (2015)
DNA double-strand breaks (DSBs) elicit the so-called DNA damage response (DDR), largely relying on ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PKcs), two members of the PI3K-like kinase family, whose respective functions
Externí odkaz:
https://doaj.org/article/ade3514d2cc9404f8b5668e7ba76674c