Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gaelle Le Friec"'
Autor:
Giuseppina Arbore, Erin E. West, Jubayer Rahman, Gaelle Le Friec, Nathalie Niyonzima, Mehdi Pirooznia, Ilker Tunc, Polychronis Pavlidis, Nicholas Powell, Yuesheng Li, Poching Liu, Aude Servais, Lionel Couzi, Veronique Fremeaux-Bacchi, Leo Placais, Alastair Ferraro, Patrick R. Walsh, David Kavanagh, Behdad Afzali, Paul Lavender, Helen J. Lachmann, Claudia Kemper
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Complement, while serving to remove pathogens in the circulation, is also important for synergizing with inflammasomes to modulate CD4 T cell activation. Here the authors show that CD46, a complement receptor expressed only in humans, is essential fo
Externí odkaz:
https://doaj.org/article/12d27a6322604934916857f1fe60bd7c
Autor:
Poching Liu, Patrick R. Walsh, Yuesheng Li, Claudia Kemper, Jubayer Rahman, Helen J. Lachmann, Leo Placais, Behdad Afzali, Paul Lavender, Alastair Ferraro, Nathalie Niyonzima, Giuseppina Arbore, Mehdi Pirooznia, Gaelle Le Friec, Polychronis Pavlidis, David J. Kavanagh, Nick Powell, Erin E. West, Ilker Tunc, Aude Servais, Lionel Couzi, Véronique Frémeaux-Bacchi
Publikováno v:
Arbore, G, West, E E, Rahman, J, Le Friec, G, Niyonzima, N, Pirooznia, M, Tunc, I, Pavlidis, P, Powell, N, Li, Y, Liu, P, Servais, A, Couzi, L, Fremeaux-Bacchi, V, Placais, L, Ferraro, A, Walsh, P R, Kavanagh, D, Afzali, B, Lavender, P, Lachmann, H J & Kemper, C 2018, ' Complement receptor CD46 co-stimulates optimal human CD8 + T cell effector function via fatty acid metabolism ', Nature Communications, vol. 9, no. 1, 4186 . https://doi.org/10.1038/s41467-018-06706-z
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
The induction of human CD4+ Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4+ T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8+ T cell (CTL) responses also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99827b7738f7632cdc8034134ccd114a
https://kclpure.kcl.ac.uk/en/publications/0522e94d-7a3a-43aa-8abb-106048652b04
https://kclpure.kcl.ac.uk/en/publications/0522e94d-7a3a-43aa-8abb-106048652b04
Publikováno v:
Freeley, S, Kemper, C & Le Friec, G 2016, ' The "ins and outs" of complement-driven immune responses ', Immunological Reviews, vol. 274, no. 1, pp. 16-32 . https://doi.org/10.1111/imr.12472
The complement system represents an evolutionary old and critical component of innate immunity where it forms the first line of defense against invading pathogens. Originally described as a heat-labile fraction of the serum responsible for the opsoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0efc643b6d20b73869f638093272db
https://doi.org/10.1111/imr.12472
https://doi.org/10.1111/imr.12472
Autor:
Wayne M. Yokoyama, Marco Colonna, Ryan W. Crump, Jill Schriewer, Ed Hembrador, Aaron S. Rapaport, Hanspeter Pircher, Jian Gao, Gaelle Le Friec, Béatrice Plougastel, R. Mark L. Buller, Yaming Wang, Susan Gilfillan, Marina Cella
Publikováno v:
Immunity. 43(6):1112-1124
CD8(+) T cells and NK cells protect from viral infections by killing virally infected cells and secreting interferon-γ. Several inhibitory receptors limit the magnitude and duration of these anti-viral responses. NKG2A, which is encoded by Klrc1, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e665e1ceb739af2ccf45c5aecddc2f
Autor:
Parul Singh, Natalia Kunz, Gaelle Le Friec, Luopin Wang, Paul Lavender, Majid Kazemian, Claudia Kemper
Publikováno v:
The Journal of Immunology. 204:76.13-76.13
Signals mediated by autocrine activation of the human-specific complement receptor CD46 during T cell receptor (TCR) stimulation are vital to Th1 induction in human CD4+ T cells, but how exactly CD46 in a molecular level mediates this role is current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fa6c34376edd546d3ebdce950a811c8
https://doi.org/10.4049/jimmunol.204.supp.76.13
https://doi.org/10.4049/jimmunol.204.supp.76.13
Autor:
Natalia Kunz, Gaelle Le Friec, Parul Singh, Paul Lavender, Majid Kazemian, Christoph Hess, Claudia Kemper
Publikováno v:
The Journal of Immunology. 204:78.19-78.19
Autocrine engagement of the complement receptor CD46, driven by T cell receptor (TCR) activation on human CD4 T cells, is critical for human Th1 induction: Processing of the intracellular CD46 domains by gamma-secretase and their nuclear translocatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67c7700e4837ac37bcac55d4746f4087
https://doi.org/10.4049/jimmunol.204.supp.78.19
https://doi.org/10.4049/jimmunol.204.supp.78.19
Publikováno v:
Nature Reviews Immunology. 14:811-820
Complement is traditionally known to be a system of serum proteins that provide protection against pathogens through direct cell lysis and the mobilization of innate and adaptive immunity. However, recent work indicates that the complement system has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30cbbedfca6e273b87910efa3a9b5e75
https://doi.org/10.1038/nri3761
https://doi.org/10.1038/nri3761
Publikováno v:
Molecular Immunology. 102:215-216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad793a004455f7fc02461a70c210defd
https://doi.org/10.1016/j.molimm.2018.06.217
https://doi.org/10.1016/j.molimm.2018.06.217
Autor:
Natalia Kunz, Gaelle Le Friec, Parul Singh, Paul Lavender, Majid Kazemian, Christoph Hess, Claudia Kemper
Publikováno v:
The Journal of Immunology. 202:125.15-125.15
Autocrine engagement of the complement receptor CD46, driven by T cell receptor (TCR) activation on human CD4+ T cells, is critical for human Th1 induction: Processing of the intracellular CD46 domains by γ-secretase and their nuclear translocation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ab71689893850a1c358c9efa7965ca9
https://doi.org/10.4049/jimmunol.202.supp.125.15
https://doi.org/10.4049/jimmunol.202.supp.125.15
Autor:
Parul Singh, Natalia Kunz, Gaelle Le Friec, Majid Kazemian, Behdad Afzali, Paul Lavender, Claudia Kemper
Publikováno v:
The Journal of Immunology. 202:125.5-125.5
Chromatin is the condensed form of DNA ‘packaged’ by positively charged histones in the nucleus. Post-translational modifications of histones regulate nucleosome dynamics, chromatin accessibility and gene expression. Signals mediated by autocrine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8707403e57e156bfe33202d9a7d202f2
https://doi.org/10.4049/jimmunol.202.supp.125.5
https://doi.org/10.4049/jimmunol.202.supp.125.5