Molecular Anatomy of Prostate Cancer and Its Implications in Active Surveillance and Early Intervention Strategies

Autor: Sandy Figiel, Géraldine Cancel-Tassin, Ian G. Mills, Alastair D. Lamb, Gaelle Fromont, Olivier Cussenot

Publikováno v: Anatomia, Vol 2, Iss 4, Pp 300-319 (2023)

Understanding prostate carcinogenesis is crucial not only for identifying new treatment targets but also for developing effective strategies to manage the asymptomatic form of the disease. There is a lack of consensus about predicting the indolent fo

Externí odkaz: https://doaj.org/article/30fd491ddfdc423390dae3dcfb369410

HSP110 as a Diagnostic but Not a Prognostic Biomarker in Colorectal Cancer With Microsatellite Instability

Autor: Gaelle Tachon, Arnaud Chong-Si-Tsaon, Thierry Lecomte, Audelaure Junca, Éric Frouin, Elodie Miquelestorena-Standley, Julie Godet, Camille Evrard, Violaine Randrian, Romain Chautard, Marie-Luce Auriault, Valérie Moulin, Serge Guyetant, Gaelle Fromont, Lucie Karayan-Tapon, David Tougeron

Publikováno v: Frontiers in Genetics, Vol 12 (2022)

Determination of microsatellite instability (MSI) using molecular test and deficient mismatch repair (dMMR) using immunohistochemistry (IHC) has major implications on colorectal cancer (CRC) management. The HSP110 T17 microsatellite has been reported

Externí odkaz: https://doaj.org/article/ee7c9693b6df4e839393f10ca1698223

Quantitative estimation of thrombus-erythrocytes using MRI. A phantom study with clot analogs and analysis by statistic regression models

Autor: Laurent Barantin, Isabelle Filipiak, Gaelle Fromont-Hankard, Jean-Philippe Cottier, Roseline Guibon, Sharon Duffy, Mariam Annan, Ana Paula Narata, Kevin Janot, Tiago R. Oliveira, Michael Gilvarry

Publikováno v: Journal of NeuroInterventional Surgery. 12:181-185

BackgroundThrombus composition has the potential to affect acute ischemic stroke (AIS) treatment.ObjectiveTo evaluate in an in vitro test the correlation of clot composition, especially erythrocytes (red blood cells (RBCs)), with the variation of sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89431335dba667fa4990c9590bc6a645
https://doi.org/10.1136/neurintsurg-2019-014950

PARP inhibitors in prostate cancers, is it time for combinations?

Autor: Diego Teyssonneau, Charles Dariane, Eric Barret, Jean-Baptiste Beauval, Laurent Brureau, Gaëlle Fiard, Gaëlle Fromont, Gilles Créhange, Mathieu Gauthé, Alain Ruffion, Raphaële Renard-Penna, Romain Mathieu, Paul Sargos, Morgan Rouprêt, Guillaume Ploussard, Guilhem Roubaud

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 16 (2024)

Despite several improvements in outcomes, metastatic prostate cancer remains deadly. Alterations in the homologous recombination repair (HRR) pathway are associated with more aggressive disease. Olaparib and rucaparib, two poly-ADP-ribose polymerase

Externí odkaz: https://doaj.org/article/606b9941033847df92fef1473b6f1a9c

Functional Organotypic Cultures of Prostate Tissues: A Relevant Preclinical Model That Preserves Hypoxia Sensitivity and Calcium Signaling

Autor: Sandy, Figiel, Côme, Pasqualin, Fanny, Bery, Veronique, Maupoil, Christophe, Vandier, Marie, Potier-Cartereau, Isabelle, Domingo, Roseline, Guibon, Franck, Bruyere, Karine, Maheo, Gaelle, Fromont

Publikováno v: American Journal of Pathology
American Journal of Pathology, 2019, 189 (6), pp.1268-1275. ⟨10.1016/j.ajpath.2019.02.017⟩
American Journal of Pathology, American Society for Investigative Pathology, 2019, 189 (6), pp.1268-1275. ⟨10.1016/j.ajpath.2019.02.017⟩

International audience; In prostate cancer research, there is a lack of valuable preclinical models. Tumor cell heterogeneity and sensitivity to microenvironment signals, such as hypoxia or extracellular calcium concentration, are difficult to reprod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::20c7e5248924a5e95f09b1730be3705a
https://hal.science/hal-02460711/document