Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Gaelle Carrat"'
Autor:
Rajamannar Thennati, Vinod Burade, Zenouska Ramchunder, Alejandra Tomas, Guy A. Rutter, Ben Jones, Gaelle Carrat, Isabelle Leclerc, Yusman Manchanda, Piero Marchetti
Publikováno v:
Diabetes. 70
Background and Aims: To characterize a novel incretin analogue which engages glucagon-like peptide-1 (GLP1R) and glucose-dependent insulinotropic peptide (GIPR) receptors. Methods: Potencies for cAMP production were determined at GLP-1R and GIPR in F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1ecb4817dd9756a9a057090dc595ff0
https://doi.org/10.2337/db21-87-lb
https://doi.org/10.2337/db21-87-lb
Autor:
Inês Cebola, Michele Solimena, Mickaël Canouil, Paul Gadue, Guy A. Rutter, Sameena Nawaz, Piero Marchetti, Leonardo Alemeida-Souza, Amna Khamis, Anke M. Schulte, Harvey T. McMahon, Gaelle Carrat, Benoit Hastoy, Shuying Jiang, Ming Hu, Fabian L. Cardenas-Diaz, Philippe Froguel, Mark Ibberson
Publikováno v:
Cell Reports
Cell Rep. 34:108703 (2021)
Cell Rep. 34:108703 (2021)
Summary Using chromatin conformation capture, we show that an enhancer cluster in the STARD10 type 2 diabetes (T2D) locus forms a defined 3-dimensional (3D) chromatin domain. A 4.1-kb region within this locus, carrying 5 T2D-associated variants, phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427694070cd0fe6438ee0cd5d923e073
http://europepmc.org/articles/PMC7972990
http://europepmc.org/articles/PMC7972990
Autor:
Gaelle Carrat, Alejandra Tomas, Rajamannar Thennati, Ben Jones, Isabelle Leclerc, Guy A. Rutter, Marie-Sophie Nguyen-Tu
Publikováno v:
Diabetes. 69
Background and Aims: We have sought to develop novel GLP-1R agonists (RA) with improved insulinotropic effects on the pancreatic beta cell, and extended duration of action. Here, we have explored the affinity for the receptor, and action on signallin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cc9a3f967a51bf9cb47d17521eb943d
https://doi.org/10.2337/db20-2100-p
https://doi.org/10.2337/db20-2100-p
Autor:
Theodoros Stylianides, Fabien Alpy, Peter I. Benke, Alexandra Piunti, Victoria Salem, Michele Solimena, Alejandra Tomas, David J. Hodson, Andrew Cakebread, Andreas Müller, Kate J. Heesom, Nur Shabrina Amirruddin, Federico Torta, Isabelle Leclerc, Leena Haataja, Peter Arvan, Timothy J. Pullen, Annie C. H. Fung, Linford J.B. Briant, Kaiying Cheng, Gaelle Carrat, Alice P.S. Kong, Dale B. Wigley, Philip A. Lewis, Richard B. Sessions, Elizabeth Haythorne, Mutian Huang, Adrian Kee Keong Teo, Guy A. Rutter, Eleni Georgiadou, Walter Distaso
Publikováno v:
Molecular Metabolism
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 40, pp.101015. ⟨10.1016/j.molmet.2020.101015⟩
bioRxiv
Molecular metabolism, 2020, 40, pp.101015. ⟨10.1016/j.molmet.2020.101015⟩
Molecular Metabolism, Vol 40, Iss, Pp 101015-(2020)
Carrat, G, Haythorne, E, Tomas, A, Haataja, L, Muller, A, Arvan, P, Piunti, A, Cheng, K, Huang, M, Pullen, T J, Georgiadou, E, Stylianides, T, Amirruddin, N S, Salem, V, Distaso, W, Cakebread, A, Heesom, K J, Lewis, P A, Hodson, D J, Briant, L J B, Fung, A, Sessions, R B, Alpy, F, Kong, A, Benke, P, Torta, F, Keong Teo, A K, Leclerc, I, Solimena, M, Wigley, DB & Rutter, G A 2020, ' The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis ', Molecular metabolism, vol. 40, 101015 . https://doi.org/10.1016/j.molmet.2020.101015
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 40, pp.101015. ⟨10.1016/j.molmet.2020.101015⟩
bioRxiv
Molecular metabolism, 2020, 40, pp.101015. ⟨10.1016/j.molmet.2020.101015⟩
Molecular Metabolism, Vol 40, Iss, Pp 101015-(2020)
Carrat, G, Haythorne, E, Tomas, A, Haataja, L, Muller, A, Arvan, P, Piunti, A, Cheng, K, Huang, M, Pullen, T J, Georgiadou, E, Stylianides, T, Amirruddin, N S, Salem, V, Distaso, W, Cakebread, A, Heesom, K J, Lewis, P A, Hodson, D J, Briant, L J B, Fung, A, Sessions, R B, Alpy, F, Kong, A, Benke, P, Torta, F, Keong Teo, A K, Leclerc, I, Solimena, M, Wigley, DB & Rutter, G A 2020, ' The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis ', Molecular metabolism, vol. 40, 101015 . https://doi.org/10.1016/j.molmet.2020.101015
Objective Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion, and decreased circulating proinsulin:insulin ratios. Although likely to serve a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee31ae299bb38311feeaf4ba6eff987
http://hdl.handle.net/10044/1/80098
http://hdl.handle.net/10044/1/80098
Autor:
Anke M. Schulte, Shuying Jiang, Sameena Nawaz, Michele Solimena, Amna Khamis, Inês Cebola, Mickaël Canouil, Guy A. Rutter, Paul Gadue, Ming Hu, Philippe Froguel, Mark Ibberson, Piero Marchetti, Fabian L. Cardenas-Diaz, Leonardo Alemeida-Souza, Harvey T. McMahon, Gaelle Carrat, Benoit Hastoy
SUMMARYGenome-wide association studies have identified thousands of genetic variants associated with type 2 diabetes (T2D) risk. Using chromatin conformation capture we show that an enhancer cluster in the STARD10 T2D locus forms a defined 3D chromat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d838ea6eafec4ca07b4b15c7b3f90b0
https://doi.org/10.1101/2020.03.31.017707
https://doi.org/10.1101/2020.03.31.017707
Autor:
Fabien Alpy, Elizabeth Haythorne, D J Hodson, Alexandra Piunti, Alice P. Kong, Gaelle Carrat, Isabelle Leclerc, Eleni Georgiadou, Timothy J. Pullen, Annie C. Fung, Peter Arvan, Victoria Salem, Andrew Cakebread, Alejandra Tomas, Walter Distaso, Theodoros Stylianides, Richard B. Sessions, Leena Haataja, Guy A. Rutter
Publikováno v:
Diabetes. 68
Aim: Risk alleles for type 2 diabetes (T2D) in the STARD10 locus, impair insulin secretion and are associated with decreased proinsulin:insulin ratios. We have shown that the T2D risk associated with variation at this locus is likely to be mediated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3398f738d87a7bea0358f180058bd7b3
https://doi.org/10.2337/db19-343-lb
https://doi.org/10.2337/db19-343-lb
Autor:
Guy Rutter, Gaelle Carrat
Publikováno v:
Diabetes. 68
Hybrid insulin peptides (HIPs) form if peptide fragments of (pro)insulin bind through peptide bonds to fragments of other proteins. We previously demonstrated that HIPs can be detected in human and murine islets by mass spectrometry, are targeted by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c334447badeedc617c5cf4181c24c1f6
https://doi.org/10.2337/db19-249-lb
https://doi.org/10.2337/db19-249-lb
Autor:
Shuying Jiang, Michele Solimena, Anke M. Schulte, Paul Gadue, Piero Marchetti, Philippe Froguel, Harvey T. McMahon, Fabian L. Cardenas-Diaz, Ming Hu, Amna Khamis, Mark Ibberson, Inês Cebola, Leonardo Alemeida-Souza, Gaelle Carrat, Mickaël Canouil, Guy A. Rutter
Publikováno v:
SSRN Electronic Journal.
Genome-wide association studies have identified hundreds of genetic variants associated with type 2 diabetes (T2D) risk. Using chromatin conformation capture we show that an enhancer cluster in the STARD10 T2D locus forms a defined 3D chromatin domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5709889fe2715a0bcb405c774fb93085
https://doi.org/10.2139/ssrn.3408005
https://doi.org/10.2139/ssrn.3408005
Autor:
Stephen Rothery, David J. Hodson, Eleni Georgiadou, Piero Marchetti, Sumeet Pal Singh, S Neda Mousavy Gharavy, Kinga Suba, Victoria Salem, Walter Distaso, Timothy J. Pullen, Nikolay Ninov, Aldara Martin-Alonso, Isabelle Leclerc, David C. A. Gaboriau, Gaelle Carrat, Linford J.B. Briant, Luis F. Delgadillo Silva, Nadeem Akhtar, Theodoros Stylianides, A. M. James Shapiro, Guy A. Rutter
Publikováno v:
Nature Metabolism
Salem, V, Silva, L D, Suba, K, Georgiadou, E, Neda Mousavy Gharavy, S, Akhtar, N, Martin-alonso, A, Gaboriau, D C A, Rothery, S M, Stylianides, T, Carrat, G, Pullen, T J, Singh, S P, Hodson, D J, Leclerc, I, Shapiro, A M J, Marchetti, P, Briant, L J B, Distaso, W, Ninov, N & Rutter, G A 2019, ' Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo ', Nature Metabolism, vol. 1, no. 6, pp. 615-629 . https://doi.org/10.1038/s42255-019-0075-2
Nature Metabolism, 1 (6
Salem, V, Silva, L D, Suba, K, Georgiadou, E, Neda Mousavy Gharavy, S, Akhtar, N, Martin-alonso, A, Gaboriau, D C A, Rothery, S M, Stylianides, T, Carrat, G, Pullen, T J, Singh, S P, Hodson, D J, Leclerc, I, Shapiro, A M J, Marchetti, P, Briant, L J B, Distaso, W, Ninov, N & Rutter, G A 2019, ' Leader β-cells coordinate Ca 2+ dynamics across pancreatic islets in vivo ', Nature Metabolism, vol. 1, no. 6, pp. 615-629 . https://doi.org/10.1038/s42255-019-0075-2
Nature Metabolism, 1 (6
Pancreatic β-cells form highly connected networks within isolated islets. Whether this behaviour pertains to the situation in vivo, after innervation and during continuous perfusion with blood, is unclear. In the present study, we used the recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a714ff573dd5ea50b9f5ae15629f318
Autor:
Pratibha Singh, Miriam Cnop, Jean-Valery Turatsinze, Marta Tesi, Carmela De Luca, Decio L. Eizirik, Gaelle Carrat, Daniela Nasteska, Miguel Lopes, Laura Giusti, Anthony Piron, Guy A. Rutter, Marco Bugliani, Philippe Froguel, Mickaël Canouil, Anke M. Schulte, Brian Rady, Paolo De Simone, Lorella Marselli, Michele Solimena, Ugo Boggi, Mark Ibberson, Bernard Thorens, Piero Marchetti, Maikel Luis Colli, Ivona Bakaj, Amna Khamis, Emanuele Bosi, Xiaoyan Yi, Daniela Campani, Peter Hecht, Vincenzo De Tata, Mara Suleiman, Alessandro Pocai, Maurizio Ronci, Lisa Norquay
Publikováno v:
Cell Rep. 33:108466 (2020)
Cell Reports, Vol 33, Iss 9, Pp 108466-(2020)
Cell reports.
Cell Reports, Vol 33, Iss 9, Pp 108466-(2020)
Cell reports.
Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate the molecular pathways underlying persistent or transient damage,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e3d43c01e65899b03ce052d84b9d52
https://doi.org/10.1016/j.celrep.2020.108466
https://doi.org/10.1016/j.celrep.2020.108466