Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gaelen K. Dwyer"'
IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease
Autor:
Gaelen K. Dwyer, Lisa R. Mathews, José A. Villegas, Anna Lucas, Anne Gonzalez de Peredo, Bruce R. Blazar, Jean-Philippe Girard, Amanda C. Poholek, Sanjiv A. Luther, Warren Shlomchik, Hēth R. Turnquist
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular pa
Externí odkaz:
https://doaj.org/article/79d274cbbf384598a5e3943e8a19aee2
Autor:
Gaelen K. Dwyer, Hēth R. Turnquist
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Detrimental inflammatory responses after solid organ transplantation are initiated when immune cells sense pathogen-associated molecular patterns (PAMPs) and certain damage-associated molecular patterns (DAMPs) released or exposed during transplant-a
Externí odkaz:
https://doaj.org/article/58878939c5454e69959f9b2b726e38c5
Publikováno v:
Annual Review of Immunology. 40:15-43
Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our understanding of homeostasis and immunity. The early findings that IL-33 is a potent driver of type 2 immun
Autor:
Gaelen K Dwyer, Lu Fan, Xue Zhang, Tengfang Li, Lisa Mathews, Johnny Saba, Emmanuel Colon, Michael Calderon, Katherine Helfrich, Mark Ross, Simon Watkins, Heth Roderick Turnquist
Publikováno v:
The Journal of Immunology. 208:175.18-175.18
Suppressive and reparative regulatory T cell (Treg) functions are described. However, in transplantation (Tx), recipient immune responses to persistent MHC differences will sustain injury and impact repair. The development of immunosuppressant-resist
Autor:
Gaelen K Dwyer, Lisa Mathews, Anna Lucas, Bruce R Blazar, Amanda Poholek, Warren Shlomchik, Heth Roderick Turnquist
Publikováno v:
The Journal of Immunology. 208:175.08-175.08
In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases Pathogen- and Damage-Associated Molecular Patterns (PAMPs and DAMPs) that generate pro-inflammatory antigen-presenting cells (APC) that secrete IL-12 to
Autor:
Regina Ondrasik, Brian M. Barth, Thomas A. Kircher, Colin M. McGill, Timothy J. Brown, Gaelen K. Dwyer, Kaitlyn C. Belknap, Cheryl P. Andam, Daniel J. Quinlan, David F. Claxton, Patrick L. Tomco
Publikováno v:
Phytotherapy Research. 32:1636-1641
Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is one of the more common pediatric malignancies in addition to occurring with high incidence in the aging population. Unfortunately, these patient groups are quite sensitive
Autor:
Lisa R. Mathews, Warren D. Shlomchik, Anna Lucas, Heth R. Turnquist, Gaelen K. Dwyer, Bruce R. Blazar
Publikováno v:
Blood. 136:1-2
Background: Graft vs. host disease (GVHD) remains a major complication of allogeneic stem cell transplantation (alloSCT). To create space for donor stem cells and prevent their rejection, alloSCT protocols rely on conditioning regimens involving chem
Autor:
Gaelen K Dwyer, Lisa Mathews, Anna Lucas, Bruce R Blazar, Warren Shlomchik, Heth Roderick Turnquist
Publikováno v:
The Journal of Immunology. 206:28.06-28.06
Graft vs host disease (GVHD) is a lethal complication after allogeneic stem cell transplantation (alloSCT), where donor T cells destroy host tissues. To create space for donor cells and prevent their rejection, alloSCT protocols use recipient conditi
Autor:
Sruti Shiva, Quan Liu, Yoojin C. Lee, Jenna L. Dziki, Simon C. Watkins, George S. Hussey, Anna S. Roessing, Joe G. Bartolacci, Tengfang Li, Murugesan Velayutham, Gaelen K. Dwyer, Steven A. Webber, Martin H. Oberbarnscheidt, Zhang Zhongqiang, Helong Dai, Heth R. Turnquist, Stephen F. Badylak, Michelle A. Wood-Trageser, James D. Wilkinson, Stacy G. Wendell, Anthony J. Demetris, Steven J. Mullet, Lisa R. Mathews
Publikováno v:
J Clin Invest
Alarmins, sequestered self-molecules containing damage-associated molecular patterns, are released during tissue injury to drive innate immune cell proinflammatory responses. Whether endogenous negative regulators controlling early immune responses a
Autor:
Anish Chakka, Uma R. Chandran, Angus W. Thomson, Yifei Zhao, Luis A. Ortiz, Gaelen K. Dwyer, Hui-Hua Li, Quan Liu, Ming-Hui Fan, Keven M. Robinson, Bruce R. Pitt, Timothy R. Billiar, Heth R. Turnquist, John F. Alcorn, Lisa R. Mathews, J. Demetris
Publikováno v:
JCI Insight.
Acute respiratory distress syndrome is an often fatal disease that develops after acute lung injury and trauma. How released tissue damage signals, or alarmins, orchestrate early inflammatory events is poorly understood. Herein we reveal that IL-33,