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pro vyhledávání: '"Gael F. P. Bories"'
Autor:
Brant E. Isakson, Norbert Leitinger, Gael F. P. Bories, Todd E. Fox, Vlad Serbulea, Scott Yeudall
Publikováno v:
Blood
Heme is an essential cofactor for numerous cellular functions, but release of free heme during hemolysis results in oxidative tissue damage, vascular dysfunction, and inflammation. Macrophages play a key protective role in heme clearance; however, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca0c326afe3969e97f7edf0727b04ad
https://europepmc.org/articles/PMC7515686/
https://europepmc.org/articles/PMC7515686/
Autor:
Vlad Serbulea, Thurl E. Harris, Katelyn W. Ahern, Clint M Upchurch, Dory E. DeWeese, Paxton Voigt, Akshaya K. Meher, Norbert Leitinger, Gael F. P. Bories
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 7, Iss, Pp 23-34 (2018)
Molecular Metabolism, Vol 7, Iss, Pp 23-34 (2018)
Objective Macrophages control tissue homeostasis and inflammation by sensing and responding to environmental cues. However, the metabolic adaptation of macrophages to oxidative tissue damage and its translation into inflammatory mechanisms remains en
Autor:
Gael F. P. Bories
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
Free heme is a very deleterious compound that promotes oxidation, inflammation and cell death, which contributes to numerous vascular pathologies including stroke, thrombosis and atherosclerosis. Rupture of red blood cells (RBC), also known as hemoly