Výsledky vyhledávání - "Gael B. Morrow"

Akademický článek

Impact of soluble thrombomodulin and activated protein C on dynamic hemostatic function in trauma: a focus on thrombin generation and clot lysis

Autor: Nicola S. Curry, Jeries Abu-Hanna, Gael B. Morrow, Robin Choudhury, Michael Laffan

Publikováno v: Haematologica, Vol 999, Iss 1 (2024)

Trauma induced coagulopathy (TIC) describes a complex set of coagulation changes affecting severely injured patients. The thrombomodulin-protein C axis is believed to be central to the evolution of TIC. Soluble thrombomodulin (sTM) levels are elevate

Externí odkaz: https://doaj.org/article/95b80d748c144ab9adde97d3b1835275

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Akademický článek

Novel therapeutics and emerging technology in haemostasis and thrombosis: highlights from the British society for haemostasis and thrombosis annual meeting

Autor: Claire S. Whyte, Gael B. Morrow, Julia S. Gauer, Samantha J. Montague, Philip L. R. Nicolson

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

The 2023 annual meeting of the British Society for Haemostasis and Thrombosis (BSHT) was held in Birmingham, United Kingdom. The theme of this year's meeting was novel therapeutics and emerging technology. Here, the exciting research presented at the

Externí odkaz: https://doaj.org/article/e021f5b227624fb7a9118eaf4440e269

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Akademický článek

Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: Results from a laboratory sub-study of the FEISTY trial

Autor: Gael B. Morrow, Timea Feller, Zoe McQuilten, Elizabeth Wake, Robert A. S. Ariëns, James Winearls, Nicola J. Mutch, Mike A. Laffan, Nicola Curry

Publikováno v: Critical Care, Vol 26, Iss 1, Pp 1-12 (2022)

Abstract Background Fibrinogen is the first coagulation protein to reach critical levels during traumatic haemorrhage. This laboratory study compares paired plasma samples pre- and post-fibrinogen replacement from the Fibrinogen Early In Severe Traum

Externí odkaz: https://doaj.org/article/2400862b5d3c498298e4fb2284d6e9c2

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Akademický článek

A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease

Autor: Gael B. Morrow, Claire S. Whyte, Nicola J. Mutch

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue plasminogen activator (tPA), and urokinase-type plasminogen activator

Externí odkaz: https://doaj.org/article/3ae1d0a608954a6f98041e977c66fca0

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Akademický článek

Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation

Autor: Gael B. Morrow, Claire S. Whyte, Nicola J. Mutch

Publikováno v: Haematologica, Vol 105, Iss 12 (2019)

Platelets harbor the primary reservoir of circulating plasminogen activator inhibitor 1 (PAI-1), but the reportedly low functional activity of this pool of inhibitor has led to debate over its contribution to thrombus stability. Here we analyze the f

Externí odkaz: https://doaj.org/article/e5d1044091b44a918694280b6a8aa05a

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Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)

Autor: Nicola Mutch, Gael B Morrow

Publikováno v: Seminars in Thrombosis and Hemostasis. 49:305-313

Plasminogen activator inhibitor 1 (PAI-1), a SERPIN inhibitor, is primarily known for its regulation of fibrinolysis. However, it is now known that this inhibitor functions and contributes to many (patho)physiological processes including inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5e16f7c938edeab6690db3d82f854e
https://doi.org/10.1055/s-0042-1758791

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Characterisation of a novel thrombomodulin c.1487delC,p.(Pro496Argfs*10) variant and evaluation of therapeutic strategies to manage the rare bleeding phenotype

Autor: Gael B. Morrow, Sarah Harper, James Beavis, P Bignell, Nicola Curry, Michael Laffan

Introduction A novel variant in the thrombomodulin (TM) gene, c.1487delC,p.(Pro496Argfs*10), referred to as Pro496Argfs*10, was identified in a family with an unexplained bleeding disorder. The Pro496Argfs*10 variant results in loss of the transmembr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c80593d6c1b5b5870c2d0cfa6d518d
http://hdl.handle.net/10044/1/84922

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Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation

Autor: Nicola J. Mutch, Gael B. Morrow, Claire S. Whyte

Publikováno v: Haematologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fc3c148257008d1eb757cdf775f6e8
https://ora.ox.ac.uk/objects/uuid:5fc95363-ebbf-491e-bc95-8c355cc2800e

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Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19

Autor: Nicola J. Mutch, Joanne L. Mitchell, Pratima Chowdary, Gael B. Morrow, Claire S. Whyte

Publikováno v: Journal of Thrombosis and Haemostasis

The global pandemic of coronavirus disease 2019 (COVID‐19) is associated with the development of acute respiratory distress syndrome (ARDS), which requires ventilation in critically ill patients. The pathophysiology of ARDS results from acute infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6112af01c92503377d398fcec7ccdd
https://pubmed.ncbi.nlm.nih.gov/32329246

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