Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Gael, Cagnone"'
Autor:
Yassine El Bakkouri, Rony Chidiac, Chantal Delisle, Jeanne Corriveau, Gael Cagnone, Vanda Gaonac’h-Lovejoy, Ashley Chin, Éric Lécuyer, Stephane Angers, Jean-Sébastien Joyal, Ivan Topisirovic, Laura Hulea, Alexandre Dubrac, Jean-Philippe Gratton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions with RNA-binding proteins that are part of stress gra
Externí odkaz:
https://doaj.org/article/95ff214a0fa9446fbd3a459e08308533
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-7 (2023)
Abstract The GPCR HCAR1 is known to be the sole receptor for lactate, which modulates its metabolic effects. Despite its significant role in many processes, mice deficient in HCAR1 exhibit no visible phenotype and are healthy and fertile. We performe
Externí odkaz:
https://doaj.org/article/851871c6b90e45f5bef76bcec45d9e36
Autor:
Rabah Dabouz, Colin W. H. Cheng, Pénélope Abram, Samy Omri, Gael Cagnone, Khushnouma Virah Sawmy, Jean-Sébastien Joyal, Michel Desjarlais, David Olson, Alexander G. Weil, William Lubell, José Carlos Rivera, Sylvain Chemtob
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-19 (2020)
Abstract Background Inflammation and particularly interleukin-1β (IL-1β), a pro-inflammatory cytokine highly secreted by activated immune cells during early AMD pathological events, contribute significantly to retinal neurodegeneration. Here, we id
Externí odkaz:
https://doaj.org/article/506aa30b38074c1d9d6c7c66eb9f544b
Autor:
Emilie Heckel, Gael Cagnone, Tapan Agnihotri, Bertan Cakir, Ashim Das, Jin Sung Kim, Nicholas Kim, Geneviève Lavoie, Anu Situ, Sheetal Pundir, Ye Sun, Florian Wünnemann, Kerry A. Pierce, Courtney Dennis, Grant A. Mitchell, Sylvain Chemtob, Flavio A. Rezende, Gregor Andelfinger, Clary B. Clish, Philippe P. Roux, Przemyslaw Sapieha, Lois E.H. Smith, Jean-Sébastien Joyal
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Dyslipidemia and autophagy have been implicated in the pathogenesis of blinding neovascular age-related macular degeneration (NV-AMD). VLDL receptor (VLDLR), expressed in photoreceptors with a high metabolic rate, facilitates the uptake of triglyceri
Externí odkaz:
https://doaj.org/article/2daa7b5d47564630a41d65386cd0a30f
Autor:
Zhongjie Fu, Chuck T Chen, Gael Cagnone, Emilie Heckel, Ye Sun, Bertan Cakir, Yohei Tomita, Shuo Huang, Qian Li, William Britton, Steve S Cho, Timothy S Kern, Ann Hellström, Jean‐Sébastien Joyal, Lois EH Smith
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-15 (2019)
Abstract The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are con
Externí odkaz:
https://doaj.org/article/3333c50737c84adcb56dde89bc82b7e9
Autor:
Ashot S. Harutyunyan, Brian Krug, Haifen Chen, Simon Papillon-Cavanagh, Michele Zeinieh, Nicolas De Jay, Shriya Deshmukh, Carol C. L. Chen, Jad Belle, Leonie G. Mikael, Dylan M. Marchione, Rui Li, Hamid Nikbakht, Bo Hu, Gael Cagnone, Warren A. Cheung, Abdulshakour Mohammadnia, Denise Bechet, Damien Faury, Melissa K McConechy, Manav Pathania, Siddhant U. Jain, Benjamin Ellezam, Alexander G. Weil, Alexandre Montpetit, Paolo Salomoni, Tomi Pastinen, Chao Lu, Peter W. Lewis, Benjamin A. Garcia, Claudia L. Kleinman, Nada Jabado, Jacek Majewski
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Lysine27-to-methionine mutations in histone H3 genes (H3K27M) occur in a subgroup of gliomas and decrease genome-wide H3K27 trimethylation. Here the authors utilise primary H3K27M tumour lines and isogenic CRISPR-edited controls and show that H3K27M
Externí odkaz:
https://doaj.org/article/0beae741fed94f66b31dab929cbfe1ba
Autor:
Julia C. Wilmanns, Raghav Pandey, Olivia Hon, Anjana Chandran, Jan M. Schilling, Elvira Forte, Qizhu Wu, Gael Cagnone, Preeti Bais, Vivek Philip, David Coleman, Heidi Kocalis, Stuart K. Archer, James T. Pearson, Mirana Ramialison, Joerg Heineke, Hemal H. Patel, Nadia A. Rosenthal, Milena B. Furtado, Mauro W. Costa
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 102-114 (2019)
Objective: Congenital heart disease (CHD) is the most frequent birth defect worldwide. The number of adult patients with CHD, now referred to as ACHD, is increasing with improved surgical and treatment interventions. However the mechanisms whereby AC
Externí odkaz:
https://doaj.org/article/54e4286b7710480bb545986201e5fddc
Autor:
Zhongjie Fu, Chenxi Qiu, Gael Cagnone, Yohei Tomita, Shuo Huang, Bertan Cakir, Yumi Kotoda, William Allen, Edward Bull, James D. Akula, Jean-Sébastien Joyal, Ann Hellström, Saswata Talukdar, Lois E.H. Smith
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102376- (2021)
Summary: The group of retinal degenerations, retinitis pigmentosa (RP), comprises more than 150 genetic abnormalities affecting photoreceptors. Finding degenerative pathways common to all genetic abnormalities may allow general treatment such as neur
Externí odkaz:
https://doaj.org/article/9de3aede5bd141988e7eeb905af219fe
Autor:
Edouard Charlebois, Carine Fillebeen, John Presley, Gael Cagnone, Véronique Lisi, Vincent-Philippe Lavallée, Jean-Sébastien Joyal, Kostas Pantopoulos
Publikováno v:
Blood. 141:271-284
Homeostatic adaptation to systemic iron overload involves transcriptional induction of bone morphogenetic protein 6 (BMP6) in liver sinusoidal endothelial cells (LSECs). BMP6 is then secreted to activate signaling of the iron hormone hepcidin (HAMP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0b884aca24e206dfffb07ce1b742db
https://doi.org/10.1182/blood.2022016987
https://doi.org/10.1182/blood.2022016987
Publikováno v:
Cells, Vol 10, Iss 8, p 1913 (2021)
The kallikrein-kinin system (KKS) contributes to retinal inflammation and neovascularization, notably in diabetic retinopathy (DR) and neovascular age-related macular degeneration (AMD). Bradykinin type 1 (B1R) and type 2 (B2R) receptors are G-protei
Externí odkaz:
https://doaj.org/article/7ae6c12b2be54916b825ed1b894cc02e