Radiation-Induced Senescence Reprograms Secretory and Metabolic Pathways in Colon Cancer HCT-116 Cells

Autor: Chandrasekharam N. Nagineni, Sarwat Naz, Rajani Choudhuri, Gadisetti V. R. Chandramouli, Murali C. Krishna, Jeffrey R. Brender, John A. Cook, James B. Mitchell

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 9, p 4835 (2021)

Understanding the global metabolic changes during the senescence of tumor cells can have implications for developing effective anti-cancer treatment strategies. Ionizing radiation (IR) was used to induce senescence in a human colon cancer cell line H

Externí odkaz: https://doaj.org/article/36ec2a8f2891409b95e5163faf2e8f5d

Supplementary Table 1b from Global Expression Profiling Identifies Signatures of Tumor Virulence in MMTV-PyMT-Transgenic Mice

Autor: Edison T. Liu, Jeffrey E. Green, Nawal W. Alkharouf, Kent W. Hunter, Gadisetti V. R. Chandramouli, Ting Hu Qiu

Supplementary Table 1a from Global Expression Profiling Identifies Signatures of Tumor Virulence in MMTV-PyMT-Transgenic Mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068d7574bd66ca4a4ea2d0f1008d223e
https://doi.org/10.1158/0008-5472.22364064.v1

Pharmacological targeting of polyamine and hypusine biosynthesis reduces tumour activity of endometrial cancer

Autor: Hong Im Kim, Chad R. Schultz, Gadisetti V. R. Chandramouli, Dirk Geerts, John I. Risinger, André S. Bachmann

Publikováno v: Journal of drug targeting, 30(6), 623-633
Kim, H I, Schultz, C R, Chandramouli, G V R, Geerts, D, Risinger, J I & Bachmann, A S 2022, ' Pharmacological targeting of polyamine and hypusine biosynthesis reduces tumour activity of endometrial cancer ', Journal of drug targeting, vol. 30, no. 6, pp. 623-633 . https://doi.org/10.1080/1061186X.2022.2036164

Endometrial cancer (EC) is a common and deadly cancer in women and novel therapeutic approaches are urgently needed. Polyamines (putrescine, spermidine, spermine) are critical for mammalian cell proliferation and MYC coordinately regulates polyamine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fcf43aaa482551b02014fe14b57f98
https://research.vumc.nl/en/publications/bbf01a78-9965-47bd-b9ba-947cec7834ee

Evaluation of partial k-space strategies to speed up time-domain EPR imaging

Autor: Sankaran, Subramanian, Gadisetti V R, Chandramouli, Alan, McMillan, Rao P, Gullapalli, Nallathamby, Devasahayam, James B, Mitchell, Shingo, Matsumoto, Murali C, Krishna

Publikováno v: Magnetic resonance in medicine. 70(3)

Narrow-line spin probes derived from the trityl radical have led to the development of fast in vivo time-domain EPR imaging. Pure phase-encoding imaging modalities based on the single-point imaging scheme have demonstrated the feasibility of three-di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b75728e24c65da3403d6ec4c607fdca9
https://pubmed.ncbi.nlm.nih.gov/23045171

The in vitro and in vivo effects of re-expressing methylated von Hippel-Lindau tumor suppressor gene in clear cell renal carcinoma with 5-aza-2'-deoxycytidine

Autor: Wade G, Alleman, Ray L, Tabios, Gadisetti V R, Chandramouli, Olga N, Aprelikova, Carlos, Torres-Cabala, Arnulfo, Mendoza, Craig, Rogers, Craig, Rodgers, Nikolai A, Sopko, W Marston, Linehan, James R, Vasselli

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 10(20)

Clear cell renal carcinoma (ccRCC) is strongly associated with loss of the von Hippel-Lindau (VHL) tumor suppressor gene. The VHL gene is functionally lost through hypermethylation in up to 19% of sporadic ccRCC cases. We theorized that re-expressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b389005f1d287852c1aa139828d94fb4
https://pubmed.ncbi.nlm.nih.gov/15501981