Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Gadi Spira"'
Autor:
Galia Tsarfaty, Hila Barash, Rinat Abramovitch, Gadi Spira, Eitan Gross, Idit Matot, Yifat Edrei, Eithan Galun, Israel Vlodavsky
Publikováno v:
Radiology. 243:727-735
Purpose: To prospectively assess functional magnetic resonance (MR) imaging during hypercapnia and hyperoxia for monitoring changes in liver perfusion and hemodynamics in rats. Materials and Methods: All experiments were performed with approval of an
Autor:
Y. Hagai, Norifumi Kawada, Gadi Spira, Mark Pines, Rafael Bruck, G. Bilu, Yulia Gnainsky, Z. Kushnirsky, Hanne Volpin, T. A. Libermann, D. P. Reinhardt, Katsutoshi Yoshizato, Arnon Nagler, Olga Genina
Publikováno v:
Cell and Tissue Research. 328:153-166
Hepatic fibrosis is associated with the activation of stellate cells (HSCs), the major source of extracellular matrix (ECM) proteins. Transforming growth factor-beta (TGF-beta), signaling via Smad3, is the most profibrogenic cytokine and the major pr
Autor:
Melia Paizi, Gadi Spira, Orna Halevy, Yulia Gnainsky, Arnon Nagler, Mark Pines, Rebbeca Taub, Raffael Bruck, Olga Genina
Publikováno v:
Cell and Tissue Research. 324:385-394
Tyrosine phosphatase PRL-1 is one of the immediate-early genes up-regulated during liver regeneration and is apparently involved in cell proliferation. Previously, we have demonstrated that halofuginone, an inhibitor of collagen type I synthesis, pre
Autor:
Melia Paizi, Rita Yeikilis, Gadi Spira, Israel Vlodavsky, Neta Ilan, Orit Pappo, Noga Gan, Orit Goldshmidt, Nidal Mawasi
Publikováno v:
The Journal of Pathology. 203:594-602
Heparan sulphate proteoglycans are major components of the liver extracellular matrix. Their cleavage by heparanase (endo-β-glucuronidase) may thus be involved in liver-specific normal and pathological processes. Heparanase mRNA and protein were exp
Publikováno v:
Biochemical and Biophysical Research Communications. 287:209-215
Liver architecture remodeling following partial hepatectomy (PHx) involves the formation of a complex network of liver sinusoids through which the blood flows. The present study examines the involvement of vascular endothelial growth factor (VEGF) an
Publikováno v:
Infection and Immunity. 66:1057-1062
The isotype and epitope specificities of antibodies both contribute to the efficacy of antibodies that mediate immunity to Cryptococcus neoformans , but the relationship between these properties is only partially understood. In this study, we analyze
Publikováno v:
Hybridoma. 14:85-90
Isotype switching of hybridoma clones may be essential when the class of the antibody produced does not suit the task for which it was generated. In those instances immunoglobulin (Ig) switch variants can be isolated in vitro but the success of isola
Publikováno v:
Hybridoma. 13:531-535
Allelic exclusion normally results in the expression of only one light and one heavy chain gene. However, some hybridomas have been reported to express two different heavy chain genes. Here we report that the IgG3 hybridoma 4H3.C8B expresses both kap
Publikováno v:
Hybridoma. 13:257-261
We have shown that one of the alleles in a hybridoma was nonproductive because the sequence in the N region of the heavy chain caused it to be out of frame and to terminate prematurely. This allele became productive, and the gamma 1 heavy chain that
Publikováno v:
Journal of Immunological Methods. 165:263-268
The use of chemiluminescence and the ELISA spot assay for identifying rare immunoglobulin switch variants is described. The technique utilizes nitrocellulose membranes and allows rapid screening of a large number of cells. The number of spots can be