Výsledky vyhledávání

Using High Molecular Precision to Study Enzymatically Induced Disassembly of Polymeric Nanocarriers: Direct Enzymatic Activation or Equilibrium-Based Degradation?

Autor: Gadi Slor, Roey J. Amir

Publikováno v: Macromolecules

Enzyme-responsive polymers and their assemblies offer great potential to serve as key materials for the design of drug delivery systems and other biomedical applications. However, the utilization of enzymes to trigger the disassembly of polymeric amp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291efec25e7197b38143e86ff0ec2ae5
https://doi.org/10.1021/acs.macromol.0c02263

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Tuning Reactivity of Micellar Nanoreactors by Precise Adjustments of the Amphiphiles and Substrates Hydrophobicity

Autor: Shreyas Shankar Wagle, Roey J. Amir, Shahar Tevet, Gadi Slor

Polymeric assemblies, such as micelles, are gaining increasing attention due to their ability to serve as nanoreactors for the execution of organic reactions in aqueous media. The ability to conduct transformations, which have been limited to organic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed00ba3569e7e1fd499e96507a4c1e3
https://doi.org/10.26434/chemrxiv.14706009

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Utilizing Self-Immolative ATRP Initiators To Prepare Stimuli-Responsive Polymeric Films from Nonresponsive Polymers

Autor: Adi Dahan, Nicole Edelstein-Pardo, Roey J. Amir, Revital Sasson, Leigh Peles-Strahl, Gadi Slor

Publikováno v: Macromolecules. 52:3268-3277

Stimuli-responsive polymers were synthesized by atom transfer radical polymerization (ATRP) using a photoresponsive self-immolative bifunctional initiator. The photoactivated self-immolative junctions allow transforming nonresponsive polymers into ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c3ba8a79370707a2e5321fe38dcbada
https://doi.org/10.1021/acs.macromol.8b02566

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Dendron-Polymer Hybrids as Tailorable Coronae of Single-Walled Carbon Nanotube

Autor: Gili Bisker, Gadi Slor, Parul Rathee, Roey J. Amir, Verena Wulf

Single-walled carbon nanotubes (SWCNTs), non-covalently functionalized by synthetic polymers, find widespread applications including sensing and imaging. Identifying new amphiphiles with interchangeable building blocks that can form unique coronae ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5f3a6c12ff2500a034a92682a45153
https://doi.org/10.26434/chemrxiv.14452785.v1

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Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks

Autor: Alis R. Olea, Lorenzo Albertazzi, Roey J. Amir, Victor Retamero De La Rosa, Silvia Pujals, Richard Hoogenboom, Ali Tigrine, Gadi Slor

Publikováno v: Biomacromolecules, 22(3), 1197-1210. American Chemical Society
Biomacromolecules
BIOMACROMOLECULES

Enzymatically degradable polymeric micelles have great potential as drug delivery systems, allowing the selective release of their active cargo at the site of disease. Furthermore, enzymatic degradation of the polymeric nanocarriers facilitates clear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6d4b6fc7a0a9dda534f57de90aae99
https://research.tue.nl/nl/publications/63a8913c-cd75-440a-9e77-9d92c5e3d854

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Mixing End Groups in Thiol-Ene/Yne Reactions as a Simple Approach toward Multienzyme-Responsive Polymeric Amphiphiles

Autor: Assaf J. Harnoy, Gadi Slor, Roey J. Amir, Nitsan Papo

Publikováno v: Synlett. 29:2582-2587

Taking advantage of the high fidelity of thiol-ene and thiol-yne chemistries, we used mixtures of thiols to prepare degradable PEG-dendron amphiphiles functionalized with two different types of enzymatically cleavable end groups. By tuning the feed r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::becc7daf190ffa42c162217224cadf67
https://doi.org/10.1055/s-0037-1611340

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Covalent functionalization of solid cellulose by divergent synthesis of chemically active dendrons

Autor: Daniel Anavi, Aviv Amirav, Merav Segal, Elizabeth Amir, Liat Frid, Roey J. Amir, Gadi Slor, Yanay Popowski

Publikováno v: Journal of Polymer Science Part A: Polymer Chemistry. 56:2103-2114

Covalent surface modification of solid cellulose with well‐defined and chemically reactive dendrons is introduced as a platform for cellulose grafting with functional materials. Surface functionalization with a first generation dendron is achieved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cce6b82a035d5eb1f3228f5abca918a3
https://doi.org/10.1002/pola.29171

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Reversible Dimerization of Polymeric Amphiphiles Acts as a Molecular Switch of Enzymatic Degradability

Autor: Ido Rosenbaum, Assaf J. Harnoy, Ram Avinery, Uri Hananel, Roey J. Amir, Roy Beck, Einat Tirosh, Gadi Slor

Publikováno v: Biomacromolecules. 18:3457-3468

Enzyme-responsive polymeric micelles have great potential as drug delivery systems due to the high selectivity and overexpression of disease-associated enzymes, which could be utilized to trigger the release of active drugs only at the target site. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db48a23ad1207d67672676430890ca81
https://doi.org/10.1021/acs.biomac.7b01150

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