Drug fever—an immune-mediated delayed type hypersensitivity reaction to Vinca alkaloids in pediatric oncology patients, possibly mediated by cysteinyl leukotrienes

Autor: Mona I. Kidon, Soad Haj Yahia, Gadi Abebe-Campino, Nancy Agmon-Levin, Michal Yelon

Publikováno v: Frontiers in Allergy, Vol 5 (2024)

BackgroundDrug hypersensitivity reactions are common in pediatric hemato-oncology patients due to multiple factors including immune compromise and pharmacological complexities. Fever can signify severe delayed-type hypersensitivity reactions such as

Externí odkaz: https://doaj.org/article/ab4c9f569247431d98b5b9fdd605668f

Hypothalamic-pituitary-gonadal function, pubertal development, and fertility outcomes in male and female medulloblastoma survivors: a single-center experience

Autor: Eve Stern, Michal Ben-Ami, Noah Gruber, Amos Toren, Shani Caspi, Gadi Abebe-Campino, Michal Lurye, Michal Yalon, Dalit Modan-Moses

Publikováno v: Neuro-Oncology.

BackgroundEndocrine deficiencies, including hypothalamic-pituitary-gonadal axis (HPGA) impairment, are common in survivors of childhood and adolescent medulloblastoma. Still, data regarding pubertal development and fecundity are limited, and few stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f88dd1e00f8549a4ce285c7a49c8ccd3
https://doi.org/10.1093/neuonc/noad009

Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance

Autor: Lee Yi Yen, Melyssa Aronson, Carol J. Swallow, Cynthia Hawkins, Lara Reichman, Rebecca C. Luiten, Sumita Roy, Michal Zapotocky, Patrick Tomboc, Christian Kratz, Michael Osborn, Junne Kamihara, Ayse Bahar Ercan, Jamie L. Maciaszek, Vanessa Bianchi, Benjamin Oshrine, Hagit N. Baris, Ossama M. Maher, Mohsin Rashid, Sara Rhode, Sharon Gardner, Annika Bronsema, David S. Ziegler, An Van Damme, Monica Newmark, Mithra Ghalibafian, Heather Hampel, Jordan R. Hansford, Vahid Fallah Azad, Michael P. Link, Simon C. Ling, Marc Remke, Shayna Zelcer, Deborah T. Blumenthal, Isabelle Scheers, Rebecca Loret De Mola, Syed Ahmer Hamid, Vanan MagimairajanIssai, Kim E. Nichols, Saunders Hsu, Catherine Goudie, Naureen Mushtaq, Ira Winer, Abeer Al-Battashi, Garth Nicholas, Roula Farah, Kami Wolfe Schneider, Rejin Kebudi, Jan Rapp, Gregory Thomas, Helen Toledano, Alvaro Lassaletta, Anne Bendel, Jeffrey Knipstein, Musa Alharbi, Gadi Abebe-Campino, Rose B. McGee, Anirban Das, Uri Tabori, Donald Basel, Alyssa Reddy, Melissa Edwards, Scott Lindhorst, Craig Harlos, Bailey Gallinger, Elizabeth Cairney, Anita Villani, Valerie Larouche, Rachel Pearlman, Maude Blundell, Gary Mason, David Sumerauer, Magnus Sabel, Aghiad Chamdin, Leslie Taylor, David Malkin, William D. Foulkes, Maura Massimino, Catherine Gilpin, Eric Bouffet, Miriam Bornhorst, Carol Durno, Enrico Opocher, Nobuko Hijiya, Zehavit Frenkel, David Samuel, Michal Lurye, Stefanie Zimmermann, Shani Caspi, Stefano Chiaravalli, David Gass, Eshetu G. Atenafu, Shlomi Constantini, Shay Ben-Shachar, Michal Yalon, Rina Dvir, Daniel Pettee, Bruce Crooks, Santanu Sen, Carl Koschmann, Raymond Bedgood, Theodore Nicolaides, Duncan Stearns, Yael Goldberg, Melissa Galati, Gabriel Robbins

Publikováno v: Paediatrics Publications
Journal of Clinical Oncology, Vol. 39, no.25, p. 2779-2790 (2021)

PURPOSE Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors. We designed a surveillance protocol for early tumor detection i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc31eca9b2efe8b55ac14084ca85e170
https://doi.org/10.1200/jco.20.02636

A novel case of prolonged Ifosfamide encephalopathy and long-term treatment with methylene blue: a case report and review of literature

Autor: Gabriel Chain, Mudit Kalia, Karen Kestenbaum, Lara Pappas, Anna Sechser-Perl, Gadi Abebe Campino, Nibal Zaghloul

Publikováno v: BMC Pediatrics
BMC Pediatrics, Vol 22, Iss 1, Pp 1-4 (2022)

Background Encephalopathy following Ifosfamide treatment is a well-described phenomenon that is typically treated with Methylene Blue (MB). Chloroacetaldehyde, a potentially neurotoxic metabolite of Ifosfamide is hypothesized to cause this encephalop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323d787e32f2542f1d7994c5400132f0
http://europepmc.org/articles/PMC8807677

Fluorodeoxyglucose Detected Changes in Brain Metabolism After Chemotherapy in Pediatric Non-Hodgkin Lymphoma

Autor: Shai Shrot, Gadi Abebe-Campino, Chen Hoffmann, Tima Davidson, Amos Toren, Simona Ben-Haim

Publikováno v: Pediatric Neurology. 92:37-42

Background Potential neurocognitive dysfunction after chemotherapy is a worrisome long-term outcome. Our objective was to evaluate the effect on brain metabolism in pediatric patients with non–central nervous system cancer treated with chemotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d0e862b238e023576c2d2a0952d78c
https://doi.org/10.1016/j.pediatrneurol.2018.10.019