The Familial alpha-Synuclein A53E Mutation Enhances Cell Death in Response to Environmental Toxins Due to a Larger Population of Oligomers

Autor: MOHITE, GM, NAVALKAR, A, KUMAR, R, MEHRA, S, DAS, S, GADHE, LG, GHOSH, D, ALIAS, B, CHANDRAWANSHI, V, RAMAKRISHNAN, A, MAJI, SK

Publikováno v: IndraStra Global.

Amyloid formation of alpha-synuclein (alpha-Syn) and its familial mutations are directly linked with Parkinson's disease (PD) pathogenesis. Recently, a new familial alpha-Syn mutation (A53E) was discovered, associated with an early onset aggressive f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=issn23813652::188089aec48c5aeb95a9bff082e81d00

Benzimidazole-based fluorophores for the detection of amyloid fibrils with higher sensitivity than Thioflavin-T.

Autor: Pravin N; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Kumar R; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Tripathi S; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Kumar P; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Mohite GM; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Navalkar A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Panigrahi R; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Singh N; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Gadhe LG; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Manchanda S; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Shimozawa M; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Nilsson P; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Johansson J; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Kumar A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Maji SK; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India., Shanmugam M; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.

Publikováno v: Journal of neurochemistry [J Neurochem] 2021 Mar; Vol. 156 (6), pp. 1003-1019. Date of Electronic Publication: 2020 Sep 09.

Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils.

Autor: Mehra S; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Ghosh D; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Kumar R; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Mondal M; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Gadhe LG; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Das S; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and.; the IITB-Monash Research Academy, Indian Institute of Technology Bombay, Mumbai 400076, India., Anoop A; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Jha NN; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Jacob RS; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Chatterjee D; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Ray S; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Singh N; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Kumar A; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and., Maji SK; From the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India and samirmaji@iitb.ac.in.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Aug 24; Vol. 293 (34), pp. 12975-12991. Date of Electronic Publication: 2018 Jun 29.

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.

Autor: Yu, Meigen¹ (AUTHOR), Ye, Hui² (AUTHOR), De-Paula, Ruth B.³ (AUTHOR), Mangleburg, Carl Grant^4,5 (AUTHOR), Wu, Timothy^4,5 (AUTHOR), Lee, Tom V.² (AUTHOR), Li, Yarong² (AUTHOR), Duong, Duc⁶ (AUTHOR), Phillips, Bridget^7,8 (AUTHOR), Cruchaga, Carlos^7,8 (AUTHOR), Allen, Genevera I.^9,10 (AUTHOR), Seyfried, Nicholas T.⁶ (AUTHOR), Al-Ramahi, Ismael^4,10,11 (AUTHOR), Botas, Juan^3,4,10,11 (AUTHOR), Shulman, Joshua M.^1,2,4,10,11 (AUTHOR) Joshua.Shulman@bcm.edu

Publikováno v: PLoS Genetics. 5/18/2023, Vol. 19 Issue 5, p1-25. 25p.

Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease.

Autor: Basu, Amrita, Patel, Neil G., Nicholson, Elijah D., Weiss, Ryan J.

Publikováno v: American Journal of Physiology: Cell Physiology; May2022, Vol. 322 Issue 5, pC849-C864, 16p