Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model.

Autor: Waddingham MT; Department of Advanced Medical Research for Pulmonary Hypertension, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia; Department of Physiology, VU University Medical Center, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Sonobe T; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan., Tsuchimochi H; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan., Edgley AJ; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia., Sukumaran V; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan., Chen YC; Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, Victoria, Australia., Hansra SS; Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, Victoria, Australia., Schwenke DO; HeartOtago and Department of Physiology, University of Otago, Dunedin, New Zealand., Umetani K; Japan Synchrotron Radiation Research Institute, Harima, Hyogo, Japan., Aoyama K; Japan Synchrotron Radiation Research Institute, Harima, Hyogo, Japan., Yagi N; Japan Synchrotron Radiation Research Institute, Harima, Hyogo, Japan., Kelly DJ; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia., Gaderi S; Department of System Physiology, Ruhr University, Bochum, Germany; Department of Cardiology, Katholisches Klinikum Bochum, St. Josef Hospital, Bochum, Germany., Herwig M; Department of System Physiology, Ruhr University, Bochum, Germany; Department of Cardiology, Katholisches Klinikum Bochum, St. Josef Hospital, Bochum, Germany., Kolijn D; Department of System Physiology, Ruhr University, Bochum, Germany., Mügge A; Department of Cardiology, Katholisches Klinikum Bochum, St. Josef Hospital, Bochum, Germany., Paulus WJ; Department of Physiology, VU University Medical Center, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Ogo T; Department of Advanced Medical Research for Pulmonary Hypertension, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan., Shirai M; Department of Advanced Medical Research for Pulmonary Hypertension, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan., Hamdani N; Department of System Physiology, Ruhr University, Bochum, Germany; Department of Cardiology, Katholisches Klinikum Bochum, St. Josef Hospital, Bochum, Germany., Pearson JT; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan; Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, Victoria, Australia; ANSTO Australian Synchrotron, Clayton, Victoria, Australia; Monash Biomedical Imaging Facility, Clayton, Victoria, Australia. Electronic address: jpearson@ncvc.go.jp.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2019 Dec; Vol. 137, pp. 119-131. Date of Electronic Publication: 2019 Oct 28.

Empagliflozin and dapagliflozin decreased atrial monoamine oxidase expression and alleviated oxidative stress in overweight non-diabetic cardiac patients.

Autor: Ionică LN; Doctoral School Medicine-Pharmacy, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Department V Internal Medicine - 1st Clinic of Medical Semiotics, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Centre for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania., Buriman DG; Doctoral School Medicine-Pharmacy, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Centre for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Department III Functional Sciences - Chair of Pathophysiology, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania., Lința AV; Doctoral School Medicine-Pharmacy, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Centre for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Department III Functional Sciences - Chair of Pathophysiology, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania., Șoșdean R; Department VI Cardiology, Clinic of Cardiology, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Institute of Cardiovascular Diseases Timișoara, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania., Lascu A; Centre for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Department III Functional Sciences - Chair of Pathophysiology, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Institute of Cardiovascular Diseases Timișoara, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania., Streian CG; Institute of Cardiovascular Diseases Timișoara, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Department VI Cardiology - Clinic of Cardiovascular Surgery, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania., Feier HB; Institute of Cardiovascular Diseases Timișoara, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Department VI Cardiology - Clinic of Cardiovascular Surgery, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania., Petrescu L; Centre for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania., Mozoș IM; Centre for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Department III Functional Sciences - Chair of Pathophysiology, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania., Sturza A; Centre for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania. sturza.adrian@umft.ro.; Department III Functional Sciences - Chair of Pathophysiology, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania. sturza.adrian@umft.ro., Muntean DM; Centre for Translational Research and Systems Medicine, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.; Department III Functional Sciences - Chair of Pathophysiology, 'Victor Babeș' University of Medicine and Pharmacy From Timișoara, Eftimie Murgu Sq. No. 2, 300041, Timișoara, Romania.

Publikováno v: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 Jul 23. Date of Electronic Publication: 2024 Jul 23.

Tackling myocardial oxidative stress with empagliflozin: are we big enough to fight heart failure with preserved ejection fraction?

Autor: Paneni, Francesco, Sciarretta, Sebastiano, Costantino, Sarah

Publikováno v: Cardiovascular Research; Feb2021, Vol. 117 Issue 2, p343-345, 3p

Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model

Autor: Takeshi Ogo, Walter Paulus, Shahrooz Gaderi, Takashi Sonobe, Sarabjit S. Hansra, Mikiyasu Shirai, Darren J. Kelly, Keiji Umetani, Yi Ching Chen, Melissa Herwig, Daryl O. Schwenke, Amanda J. Edgley, James T. Pearson, Mark T. Waddingham, Vijayakumar Sukumaran, Kohki Aoyama, Andreas Mügge, Nazha Hamdani, Naoto Yagi, Detmar Kolijn, Hirotsugu Tsuchimochi

Publikováno v: Waddingham, M T, Sonobe, T, Tsuchimochi, H, Edgley, A J, Sukumaran, V, Chen, Y C, Hansra, S S, Schwenke, D O, Umetani, K, Aoyama, K, Yagi, N, Kelly, D J, Gaderi, S, Herwig, M, Kolijn, D, Mügge, A, Paulus, W J, Ogo, T, Shirai, M, Hamdani, N & Pearson, J T 2019, ' Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model ', Journal of Molecular and Cellular Cardiology, vol. 137, pp. 119-131 . https://doi.org/10.1016/j.yjmcc.2019.10.005
Journal of Molecular and Cellular Cardiology, 137, 119-131. Academic Press Inc.

Coronary microvessel endothelial dysfunction and nitric oxide (NO) depletion contribute to elevated passive tension of cardiomyocytes, diastolic dysfunction and predispose the heart to heart failure with preserved ejection fraction. We examined if di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9dff0e2b0ab192649f2441bc423abb
https://research.vumc.nl/en/publications/c7bc9c49-37e6-42cc-9e8d-7b434bee10a7