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Akademický článek

Anticholinergic exposure and its association with dementia/Alzheimer's disease and mortality in older adults.

Autor: Poonawalla IB; Humana Healthcare Research, Humana Inc., 500 W Main St, Louisville, KY, 40202, USA. IPoonawalla@humana.com., Xu Y; Humana Healthcare Research, Humana Inc., 500 W Main St, Louisville, KY, 40202, USA., Gaddy R; Humana Pharmacy Solutions, Humana Inc., 500 W Main St, Louisville, KY, 40202, USA., James A; Humana Pharmacy Solutions, Humana Inc., 500 W Main St, Louisville, KY, 40202, USA., Ruble M; Humana Pharmacy Solutions, Humana Inc., 500 W Main St, Louisville, KY, 40202, USA., Burns S; Humana Pharmacy Solutions, Humana Inc., 500 W Main St, Louisville, KY, 40202, USA., Dixon SW; Humana Healthcare Research, Humana Inc., 500 W Main St, Louisville, KY, 40202, USA., Suehs BT; Humana Healthcare Research, Humana Inc., 500 W Main St, Louisville, KY, 40202, USA.

Publikováno v: BMC geriatrics [BMC Geriatr] 2023 Jun 30; Vol. 23 (1), pp. 401. Date of Electronic Publication: 2023 Jun 30.

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ANTICHOLINERGIC USE ASSOCIATED WITH INCREASED INCIDENCE OF FALLS AND FRACTURES IN PATIENTS WITH OVERACTIVE BLADDER

Autor: Katherine Gooch, Caplan E, Gaddy R, Hayden J, Suehs B, Daniel B. Ng

Anticholinergic use is common in the elderly, and among patients with overactive bladder (OAB). We conducted a historical cohort study examining the relationship between anticholinergic exposure and intensity on the risk of falls and fractures based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d214c58f6dcf31736faa015a1fab0a0
https://europepmc.org/articles/PMC6226897/

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Akademický článek

The hydroxycarboxylic acid receptor HCA2 is required for the protective effect of ketogenic diet in epilepsy.

Autor: Richardson, Jill C.¹ (AUTHOR) jill.richardson1@msd.com, Higgins, Guy A.² (AUTHOR), Upton, Neil³ (AUTHOR), Massey, Peter⁴ (AUTHOR), Cunningham, Mark^4,5 (AUTHOR), Wilson, Steve⁶ (AUTHOR), Holenz, Joerg⁷ (AUTHOR), Taylor, Colleen³ (AUTHOR), Lavrov, Arseniy⁸ (AUTHOR), Lin, Hong⁷ (AUTHOR), Matsuoka, Yasuji⁷ (AUTHOR), Brown, Andrew J.⁹ (AUTHOR) abrown43800@gmail.com

Publikováno v: Pharmacology Research & Perspectives. Dec2024, Vol. 12 Issue 6, p1-11. 11p.

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Akademický článek

Medication Exposure and Risk of Dementia and Alzheimer's Disease.

Autor: Sharma, Niti¹ (AUTHOR) nitisharma@gachon.ac.kr, An, Seong Soo A.¹ (AUTHOR) seongaan@gachon.ac.kr, Kim, Sang Yun² (AUTHOR) seongaan@gachon.ac.kr

Publikováno v: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 23, p12850. 33p.

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Akademický článek

GSK256073 acutely regulates NEFA levels via HCA2 agonism but does not achieve durable glycaemic control in type 2 diabetes. A randomised trial.

Autor: Dobbins R; GlaxoSmithKline, Drug Discovery, Research Triangle Park, NC, USA., Byerly R; GlaxoSmithKline, Drug Discovery, Research Triangle Park, NC, USA., Gaddy R; GlaxoSmithKline, Drug Discovery, Research Triangle Park, NC, USA., Gao F; GlaxoSmithKline, Quantitative Sciences, Upper Merion, PA, USA., Mahar K; GlaxoSmithKline, Quantitative Sciences, Upper Merion, PA, USA., Napolitano A; GlaxoSmithKline, Immuno-Inflammation Therapeutic Area, Stevenage, UK., Ambery P; Department of Endocrinology and Diabetes, Addenbrooke's Hospital, Cambridge, UK., Le Monnier de Gouville AC; GlaxoSmithKline, Drug Discovery, Laboratoire GSK, 27av du Quebec, 91951 les Ulis Cedex, France. Electronic address: anne-charlotte.m.degouville@gsk.com.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2015 May 15; Vol. 755, pp. 95-101. Date of Electronic Publication: 2015 Mar 13.

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