A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development.

Autor: Fan AT; Department of Chemistry and Biochemistry, University of California, San Diego., Gadbois GE; Department of Chemistry and Biochemistry, University of California, San Diego., Huang HT; The Broad Institute of Harvard and MIT.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston., Chaudhry C; Discovery Technologies Molecular Pharmacology, J&J Innovative Medicine, Spring House, Pennsylvania, 19477, United States., Jiang J; Department of Chemistry and Biochemistry, University of California, San Diego., Sigua LH; Medical Scientist Training Program, University of California, San Diego., Smith ER; Department of Chemistry and Biochemistry, University of California, San Diego., Wu S; Department of Chemistry and Biochemistry, University of California, San Diego., Poirier GJ; Department of Chemistry and Biochemistry, University of California, San Diego., Dunne-Dombrink K; Department of Chemistry and Biochemistry, University of California, San Diego., Goyal P; Department of Chemistry and Biochemistry, University of California, San Diego., Tao AJ; Department of Chemistry and Biochemistry, University of California, San Diego., Sellers WR; The Broad Institute of Harvard and MIT.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston., Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston., Ferguson FM; Department of Chemistry and Biochemistry, University of California, San Diego.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Nov 27, pp. e202417272. Date of Electronic Publication: 2024 Nov 27.

ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC.

Autor: Tran NL; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA.; Cancer Molecular Therapeutics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA., Jiang J; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA., Ma M; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA., Gadbois GE; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA., Gulay KCM; Department of Surgery, Division of Surgical Oncology, UCSD Moores Cancer Center, University of California San Diego, La Jolla, CA., Verano A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02115., Zhou H; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA., Huang CT; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA., Scott DA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA., Bang AG; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA., Tiriac H; Department of Surgery, Division of Surgical Oncology, UCSD Moores Cancer Center, University of California San Diego, La Jolla, CA., Lowy AM; Department of Surgery, Division of Surgical Oncology, UCSD Moores Cancer Center, University of California San Diego, La Jolla, CA., Wang ES; Cancer Molecular Therapeutics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA., Ferguson FM; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 21. Date of Electronic Publication: 2024 May 21.

A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes in situ .

Autor: Tao AJ; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093., Jiang J; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093., Gadbois GE; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093., Goyal P; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093., Boyle BT; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093., Mumby EJ; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112., Myers SA; Laboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, CA 92037., English JG; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112., Ferguson FM; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 22. Date of Electronic Publication: 2023 Aug 22.

Peptoids advance multidisciplinary research and undergraduate education in parallel: Sequence effects on conformation and lipid interactions.

Autor: Jimenez CJ; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Tan J; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Dowell KM; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Gadbois GE; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Read CA; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Burgess N; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Cervantes JE; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Chan S; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Jandaur A; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Karanik T; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Lee JJ; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Ley MC; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., McGeehan M; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., McMonigal A; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Palazzo KL; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Parker SA; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Payman A; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Soria M; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Verheyden L; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Vo VT; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Yin J; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Calkins AL; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Fuller AA; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A., Stokes GY; Department of Chemistry & Biochemistry, Santa Clara University, Santa Clara, California, U.S.A.

Publikováno v: Biopolymers [Biopolymers] 2019 Apr; Vol. 110 (4), pp. e23256. Date of Electronic Publication: 2019 Jan 11.