A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes

Autor: Sandrine Luce, Sophie Guinoiseau, Alexis Gadault, Franck Letourneur, Patrick Nitschke, Marc Bras, Michel Vidaud, Pierre Charneau, Etienne Larger, Maikel L. Colli, Decio L. Eizirik, François Lemonnier, Christian Boitard

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1 mouse. This mouse is deficient of murine major histocompatibility complex class I and class II

Externí odkaz: https://doaj.org/article/6206b24d7ab14e419c5c8a08cad4d3d1

Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells

Autor: Alexis Gadault, Anne-Sophie Vercoutter-Edouart, Ninon Very, Amélie Decourcelle, Tony Lefebvre, Ganna Panasyuk, Ikram El Yazidi-Belkoura, Stéphan Hardivillé, Céline Schulz, Marlène Mortuaire, Quentin Lemaire, Sadia Raab, Steffi Baldini, Vanessa Dehennaut

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2021, Cellular and Molecular Life Sciences, 78 (10), ⟨10.1007/s00018-021-03857-z⟩
Cellular and Molecular Life Sciences, 2021, Cellular and Molecular Life Sciences, 78 (10), ⟨10.1007/s00018-021-03857-z⟩

International audience; Fatty acid synthase (FASN) participates in many fundamental biological processes, including energy storage and signal transduction, and is overexpressed in many cancer cells. We previously showed in a context of lipogenesis th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2046a0425144f2036c092541a8e856ea
https://doi.org/10.1007/s00018-021-03857-z

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Humanized Mouse Model to Study Type 1 Diabetes

Autor: Patrick Nitschke, Sophie Guinoiseau, B. Blondeau, Alexis Gadault, François Lemonnier, Christian Boitard, Eric Pasmant, Sandrine Luce, Michel Vidaud, Franck Letourneur

Publikováno v: Diabetes. 67(9)

Key requirements in type 1 diabetes (T1D) are in setting up new assays as diagnostic biomarkers that will apply to prediabetes, likely T-cell assays, and in designing antigen-specific therapies to prevent T1D development. New preclinical models of T1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3c809f65d11cba7a973b0cfe80716c
https://pubmed.ncbi.nlm.nih.gov/29967002

OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis.

Autor: Chunlei He¹, Qiang Wu², Zhaogan Zeng², Yadong Yang¹, Huabin He¹, Meiyu Hu¹, Sheng Liu¹ chunleihe1983@126.com

Publikováno v: Autoimmunity. Dec2024, Vol. 57 Issue 1, p1-10. 10p.