Výsledky vyhledávání - "Gad B. Kletter"

Phase 3 Trial of a Small-volume Subcutaneous 6-Month Duration Leuprolide Acetate Treatment for Central Precocious Puberty

Autor: Mirta Gryngarten, Erica A. Eugster, Karen O Klein, Bradley S. Miller, Matthew Benson, Gad B. Kletter, Nelly Mauras, Tala Dajani, Analia Freire

Publikováno v: The Journal of Clinical Endocrinology and Metabolism

Context Gonadotropin-releasing hormone agonists (GnRHas) are standard of care for central precocious puberty (CPP). A 6-month subcutaneous injection has recently been approved by the Food and Drug Administration. Objective Determine efficacy, pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c58b51f658d1daee9f34c94f61091b
http://europepmc.org/articles/PMC7442270

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A Randomized Safety and Efficacy Study of Somavaratan (VRS-317), a Long-Acting rhGH, in Pediatric Growth Hormone Deficiency

Autor: Eric Humphriss, George M. Bright, Huong Jil Nguyen, Douglas Rogers, Jerome A. Moore, David Ng, Gad B. Kletter, Wayne V. Moore, Bradley S. Miller, Jeffrey L. Cleland

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 101:1091-1097

Context: Somavaratan (VRS-317) is a long-acting form of recombinant human GH under development for children and adults with GH deficiency (GHD). Objectives: To determine the optimal somavaratan dose regimen to normalize IGF-1 in pediatric GHD and to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ffd7d57a18b4f657bcd1d82f9453ad
https://doi.org/10.1210/jc.2015-3279

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Tumor localization and biochemical response to cure in tumor-induced osteomalacia

Autor: Gad B Kletter, Richard M. Sherry, Diana Ovejero Crespo, Clara C. Chen, Alison M. Boyce, Lori C. Guthrie, Andrew J. Dwyer, William H. Chong, Richard Chang, Diala El-Maouche, Felasfa M. Wodajo, James C. Reynolds, Marilyn H. Kelly, Panagiota Andreopoulou, Nisan Bhattacharyya, Michael T. Collins, Rachel I Gafni

Publikováno v: Journal of Bone and Mineral Research. 28:1386-1398

Tumor-induced osteomalacia (TIO) is a rare disorder of phosphate wasting due to fibroblast growth factor-23 (FGF23)-secreting tumors that are often difficult to locate. We present a systematic approach to tumor localization and postoperative biochemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::830cc3954d8dcacaeb6e11e93f4b8fde
https://doi.org/10.1002/jbmr.1881

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Inherited germline TP53 mutation encodes a protein with an aberrant C-terminal motif in a case of pediatric adrenocortical tumor

Autor: Emilia M. Pinto, Jesse J. Jenkins, Gad B. Kletter, Jinling Wang, John P. Lawrence, Raul C. Ribeiro, Lisa M. McGregor, Richard W. Kriwacki, Sheila A. Shurtleff, Gerard P. Zambetti

Publikováno v: Familial Cancer

Childhood adrenocortical tumor (ACT), a very rare malignancy, has an annual worldwide incidence of about 0.3 per million children younger than 15 years. The association between inherited germline mutations of the TP53 gene and an increased predisposi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bde2380ee76da01dac12cec370832c
https://doi.org/10.1007/s10689-010-9392-z

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Efficacy and Safety of Histrelin Subdermal Implant in Children with Central Precocious Puberty: A Multicenter Trial

Autor: Peter A. Lee, Gad B. Kletter, William Gray, Erica A. Eugster, Edward O. Reiter, Lawrence A. Silverman, Paul Saenger, Dorothy I. Shulman, Lisa Flood, David Tierney, William L. Clarke, E. Kirk Neely

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 92:1697-1704

GnRH analog (GnRHa) therapy for central precocious puberty (CPP) typically involves im injections. The histrelin implant is a new treatment that provides a continuous slow release of the GnRHa histrelin.The objective of the study was to investigate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc048c3fcfd52cfb5d03e147e84bd85
https://doi.org/10.1210/jc.2006-2479

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Long-Term Continuous Suppression With Once-Yearly Histrelin Subcutaneous Implants for the Treatment of Central Precocious Puberty: A Final Report of a Phase 3 Multicenter Trial

Autor: Katherine Lewis, E. Kirk Neely, Erica A. Eugster, Surya Chitra, Oksana Terleckyj, Lawrence A. Silverman, Gad B. Kletter

Publikováno v: The Journal of clinical endocrinology and metabolism. 100(6)

Context and Objective: The histrelin implant has proven to be an effective method of delivering GnRH analog (GnRHa) therapy to children with central precocious puberty (CPP), yet there are limited data available regarding hormonal suppression and aux

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18db87b3cefe9e40aa02b99f452c08a5
https://pubmed.ncbi.nlm.nih.gov/25917361

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Agenesis of the Mesencephalon and Metencephalon with Cerebellar Hypoplasia: Putative Mutation in theEN2Gene—Report of 2 Cases in Early Infancy

Autor: Gad B. Kletter, Denis R. Benjamin, Harvey B. Sarnat, Joseph R. Siebert, Sarah R. Cheyette

Publikováno v: Pediatric and Developmental Pathology. 5:54-68

Congenital absence of the midbrain and upper pons is a rare human malformation. We describe two unrelated infants with this anomaly and cerebellar hypoplasia who were born at term but died in early infancy from lack of central respiratory drive. MRI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcaad687dfc3d7a40b3387eaa81fec73
https://doi.org/10.1007/s10024-001-0103-5

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In Pubertal Girls, Naloxone Fails to Reverse the Suppression of Luteinizing Hormone Secretion by Estradiol1

Autor: Vasantha Padmanabhan, Carol M. Foster, Wensheng Guo, Ayse Pinar Cemeroglu, Robert P. Kelch, John C. Marshall, Gad B. Kletter, Morton B. Brown

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 83:3501-3506

Estradiol (E2) negative feedback on LH secretion was examined in 10 pubertal girls, testing the hypothesis that E2 suppresses LH pulse frequency and amplitude through opioid pathways. At 1000 h, a 32-h saline infusion was given, followed 1 week later

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c7f50bda7dca305a57c1554fbacc7ff
https://doi.org/10.1210/jcem.83.10.5207

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Onset of acquired autoimmune hypothyroidism in infancy: a presentation of delayed gross-motor development and rhabdomyolysis

Autor: Thomas E. Numrych, Gad B. Kletter, Daniel F. Gunther, Harvey K. Chiu

Publikováno v: European Journal of Pediatrics. 165:320-322

We report the case of a 23-month-old girl who presented with poor growth and delayed attainment of gross-motor milestones. Elevated creatine phosphokinase (CPK) indicated rhabdomyolysis, ultimately attributed to severe, acquired autoimmune hypothyroi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071137bc9a86fbcb432d7cde841a883b
https://doi.org/10.1007/s00431-005-0051-6

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