Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Gad Abraham"'
Autor:
Sara Jafarbeiki, Amin Sakzad, Shabnam Kasra Kermanshahi, Raj Gaire, Ron Steinfeld, Shangqi Lai, Gad Abraham, Chandra Thapa
Publikováno v:
Informatics in Medicine Unlocked, Vol 31, Iss , Pp 100988- (2022)
Privacy and security issues limit the query executions over genomics datasets, notably single nucleotide polymorphisms (SNPs), raised by the sensitivity of this type of data. Therefore, it is important to ensure that executing queries on these datase
Externí odkaz:
https://doaj.org/article/1c6e8f8ebdbb48999a2db262b990c12e
Autor:
Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S. Butterworth, Joanna M. M. Howson, Michael Inouye, Martin Dichgans
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Stroke risk is influenced by genetic and lifestyle factors and previously a genomic risk score (GRS) for stroke was proposed, albeit with limited predictive power. Here, Abraham et al. develop a metaGRS that is composed of several stroke-related GRSs
Externí odkaz:
https://doaj.org/article/9a7c199b224d44308d309a590c357f39
Autor:
Luanluan Sun, Lisa Pennells, Stephen Kaptoge, Christopher P Nelson, Scott C Ritchie, Gad Abraham, Matthew Arnold, Steven Bell, Thomas Bolton, Stephen Burgess, Frank Dudbridge, Qi Guo, Eleni Sofianopoulou, David Stevens, John R Thompson, Adam S Butterworth, Angela Wood, John Danesh, Nilesh J Samani, Michael Inouye, Emanuele Di Angelantonio
Publikováno v:
PLoS Medicine, Vol 18, Iss 1, p e1003498 (2021)
BackgroundPolygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quantify the potential advantage of adding information on PRSs to conventional risk factors in the primary prevention of CVD.Me
Externí odkaz:
https://doaj.org/article/80a652d13d8e4befaccf54f0b7082075
Autor:
Artika P. Nath, Scott C. Ritchie, Sean G. Byars, Liam G. Fearnley, Aki S. Havulinna, Anni Joensuu, Antti J. Kangas, Pasi Soininen, Annika Wennerström, Lili Milani, Andres Metspalu, Satu Männistö, Peter Würtz, Johannes Kettunen, Emma Raitoharju, Mika Kähönen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti, Terho Lehtimäki, Gad Abraham, Olli Raitakari, Veikko Salomaa, Markus Perola, Michael Inouye
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Immunometabolism plays a central role in many cardiometabolic diseases. However, a robust map of immune-related gene networks in circulating human cells, their interactions with metabolites, and their genetic control is still lack
Externí odkaz:
https://doaj.org/article/e180785c8f2d4968ab0cf6652e950915
Autor:
Scott C Ritchie, Johannes Kettunen, Marta Brozynska, Artika P Nath, Aki S Havulinna, Satu Männistö, Markus Perola, Veikko Salomaa, Mika Ala-Korpela, Gad Abraham, Peter Würtz, Michael Inouye
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223692 (2019)
BackgroundGlycA is a nuclear magnetic resonance (NMR) spectroscopy biomarker that predicts risk of disease from myriad causes. It is heterogeneous; arising from five circulating glycoproteins with dynamic concentrations: alpha-1 antitrypsin (AAT), al
Externí odkaz:
https://doaj.org/article/5ceac96a58344eb8880965da4ef607d4
Autor:
Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S. Butterworth, Joanna M. M. Howson, Michael Inouye, Martin Dichgans
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/d6bc43a96f634d31930af051d907451a
Autor:
Sean G Byars, Qin Qin Huang, Lesley-Ann Gray, Andrew Bakshi, Samuli Ripatti, Gad Abraham, Stephen C Stearns, Michael Inouye
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006328 (2017)
Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their polygenic n
Externí odkaz:
https://doaj.org/article/ecb7ea78842d449f96c5794139ce2ef1
Autor:
Benjamin Goudey, Gad Abraham, Eder Kikianty, Qiao Wang, Dave Rawlinson, Fan Shi, Izhak Haviv, Linda Stern, Adam Kowalczyk, Michael Inouye
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172826 (2017)
Interaction analysis of GWAS can detect signal that would be ignored by single variant analysis, yet few robust interactions in humans have been detected. Recent work has highlighted interactions in the MHC region between known HLA risk haplotypes fo
Externí odkaz:
https://doaj.org/article/6ab291aa82014ab7827db4724185604e
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004137 (2014)
Practical application of genomic-based risk stratification to clinical diagnosis is appealing yet performance varies widely depending on the disease and genomic risk score (GRS) method. Celiac disease (CD), a common immune-mediated illness, is strong
Externí odkaz:
https://doaj.org/article/4c73e31bd9864755a74d85c57c05135f
Autor:
Gad Abraham, Michael Inouye
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93766 (2014)
Principal component analysis (PCA) is routinely used to analyze genome-wide single-nucleotide polymorphism (SNP) data, for detecting population structure and potential outliers. However, the size of SNP datasets has increased immensely in recent year
Externí odkaz:
https://doaj.org/article/7c52eb15209244efa849360d96256343