Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy.

Autor: Božina N; Department of Pharmacology, Zagreb University School of Medicine, Zagreb, Croatia., Sporiš IŠ; Department of Neurology, University Hospital Dubrava, Zagreb, Croatia.; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, Croatia., Domjanović IK; Croatian Agency for Medicinal Products and Medical Devices, Zagreb, Croatia., Ganoci L; Division of Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia., Šimičević L; Division of Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia., Lovrić M; Analytical Toxicology and Pharmacology Division, Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia., Romić ZČ; Department of Neurology, University Hospital Dubrava, Zagreb, Croatia., Gadže ŽP; Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia., Trkulja V; Department of Pharmacology, Zagreb University School of Medicine, Zagreb, Croatia. vladimir.trkulja@mef.hr.

Publikováno v: European journal of clinical pharmacology [Eur J Clin Pharmacol] 2023 Aug; Vol. 79 (8), pp. 1117-1129. Date of Electronic Publication: 2023 Jun 20.