Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Gad, Kimmel"'
Publikováno v:
Bioinformatics (Oxford, England), vol 25, iss 12
Bioinformatics
Bioinformatics
A characterization of the genetic variation of recently admixed populations may reveal historical population events, and is useful for the detection of single nucleotide polymorphisms (SNPs) associated with diseases through association studies and ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efdeeb3f88b7ed6727322141bdb3bce
https://doi.org/10.1093/bioinformatics/btp197
https://doi.org/10.1093/bioinformatics/btp197
Publikováno v:
The American Journal of Human Genetics. 83(6):675-683
The central questions asked in whole-genome association studies are how to locate associated regions in the genome and how to estimate the significance of these findings. Researchers usually do this by testing each SNP separately for association and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ccd72884c21d65fcfe7a588e01c231
Publikováno v:
The American Journal of Human Genetics. 82(2):290-303
Large-scale genotyping of SNPs has shown a great promise in identifying markers that could be linked to diseases. One of the major obstacles involved in performing these studies is that the underlying population substructure could produce spurious as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5ce19d3fd497583fd5ef18e34824c1
Autor:
Ron Shamir, Gad Kimmel
Publikováno v:
Journal of Computational Biology. 12:1243-1260
We present a new stochastic model for genotype generation. The model offers a compromise between rigid block structure and no structure altogether: It reflects a general blocky structure of haplotypes, but also allows for "exchange" of haplotypes at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e66d6ed972e7fb0b810936eb794b89
https://doi.org/10.1089/cmb.2005.12.1243
https://doi.org/10.1089/cmb.2005.12.1243
Publikováno v:
INFORMS Journal on Computing. 16:360-370
The study of haplotypes and their diversity in a population is central to disease-association research. We study several problems arising in haplotype block partitioning. Our objective function is the total number of distinct haplotypes in blocks. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f26a176b462611adb2f88a4b9d1fff1
https://doi.org/10.1287/ijoc.1040.0088
https://doi.org/10.1287/ijoc.1040.0088
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783540788386
RECOMB
RECOMB
Inference of ancestral information in recently admixed populations, in which every individual is composed of a mixed ancestry (e.g., African Americans in the United States), is a challenging problem. Several previous model-based approaches to admixtu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8078ac0e7029b6ca3c1e03731af546
https://doi.org/10.1007/978-3-540-78839-3_37
https://doi.org/10.1007/978-3-540-78839-3_37
Population stratification can be a serious obstacle in the analysis of genomewide association studies. We propose a method for evaluating the significance of association scores in whole-genome cohorts with stratification. Our approach is a randomizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eede406f5be75d5e685be592cc3d763
https://europepmc.org/articles/PMC2265648/
https://europepmc.org/articles/PMC2265648/
Autor:
Herma Fidder, Gad Kimmel, Amir Karban, Ofir Davidovich, Rami Eliakim, Esther Leshinsky-Silver, Maza Itay, Matti Waterman, Ron Shamir, Arie Levine
Publikováno v:
The American journal of gastroenterology. 102(8)
OBJECTIVES: Perianal disease (PD) is a frequent complication of Crohn’s disease (CD). The lack of association between PD and development of intestinal penetrating disease may suggest that PD is a distinct phenotype with specific genetic or clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c233416351e30c362e4f8089b559ef7
https://pubmed.ncbi.nlm.nih.gov/17509030
https://pubmed.ncbi.nlm.nih.gov/17509030
Publikováno v:
BMC Bioinformatics, Vol 8, Iss 1, p 36 (2007)
BMC Bioinformatics
BMC Bioinformatics
Background Genotype information generated by individual and international efforts carries the promise of revolutionizing disease studies and the association of phenotypes with alleles and haplotypes. Given the enormous amounts of public genotype data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b8dbb612baddc0a7737b870eb9d781
http://www.biomedcentral.com/1471-2105/8/36
http://www.biomedcentral.com/1471-2105/8/36
Autor:
M. Fridlander, Arie Levine, Gad Kimmel, Amir Karban, Sarit Cohen, Esther Leshinsky-Silver, O. Davidowich, Ron Shamir
Publikováno v:
International journal of colorectal disease. 22(9)
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract associated with dysregulation of the immune response. It is caused by a combination of environmental and genetic factors. Patients with CD have a TH1-type inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e76dec46d406941e5e6672550524f90
https://pubmed.ncbi.nlm.nih.gov/17333217
https://pubmed.ncbi.nlm.nih.gov/17333217