β-Amyloid impairs Proteasome structure and function. Proteasome activation mitigates amyloid induced toxicity and cognitive deficits.

Autor: Davidson K, Bano M, Parker D, Osmulski P, Gaczynska M, Pickering AM

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 25. Date of Electronic Publication: 2024 Oct 25.

Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy.

Autor: Hussong SA; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA.; Oklahoma City Veterans Health Care System, 921 NE 13th Street, Oklahoma City, OK, 73104, USA., Banh AQ; South Texas Medical Scientist Training Program, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, 4939 Charles Katz Drive, San Antonio, TX, 78229, USA., Van Skike CE; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, 4939 Charles Katz Drive, San Antonio, TX, 78229, USA., Dorigatti AO; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, 4939 Charles Katz Drive, San Antonio, TX, 78229, USA., Hernandez SF; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, 4939 Charles Katz Drive, San Antonio, TX, 78229, USA., Hart MJ; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA.; Center for Therapeutic Science, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA., Ferran B; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA., Makhlouf H; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA., Gaczynska M; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, 4939 Charles Katz Drive, San Antonio, TX, 78229, USA.; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA., Osmulski PA; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, 4939 Charles Katz Drive, San Antonio, TX, 78229, USA.; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA., McAllen SA; Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA.; Mitchell Center for Neurodegenerative Disease, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA.; Sealy Center for Vaccine Development, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA., Dineley KT; Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA.; Mitchell Center for Neurodegenerative Disease, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA.; Sealy Center for Vaccine Development, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA., Ungvari Z; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA.; Department of Neurosurgery, University of Oklahoma Health Sciences Center, 800 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA.; International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine, Department of Public Health, Semmelweis University, H-1085 Budapest, Üllői út 26, Budapest, Hungary., Perez VI; Hevolution Foundation, 5.08, Riyadh, 13519, Saudi Arabia., Kayed R; Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA.; Mitchell Center for Neurodegenerative Disease, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA.; Sealy Center for Vaccine Development, University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA., Galvan V; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA. Veronica-GalvanHart@ouhsc.edu.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK, 73104, USA. Veronica-GalvanHart@ouhsc.edu.; Oklahoma City Veterans Health Care System, 921 NE 13th Street, Oklahoma City, OK, 73104, USA. Veronica-GalvanHart@ouhsc.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Apr 25; Vol. 14 (1), pp. 2367. Date of Electronic Publication: 2023 Apr 25.

Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models.

Autor: Chocron ES; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA., Munkácsy E; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA., Kim HS; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; Department of Molecular Medicine, UT Health San Antonio, San Antonio, TX, USA.; Center for Neurodegeneration and Experimental Therapeutics (CNET), Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.; Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL, USA., Karpowicz P; Department of Organic Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland., Jiang N; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; Department of Molecular Medicine, UT Health San Antonio, San Antonio, TX, USA., Van Skike CE; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; Department of Cellular and Integrative Physiology, UT Health San Antonio, San Antonio, TX, USA., DeRosa N; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; Department of Cellular and Integrative Physiology, UT Health San Antonio, San Antonio, TX, USA., Banh AQ; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; Department of Cellular and Integrative Physiology, UT Health San Antonio, San Antonio, TX, USA., Palavicini JP; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA., Wityk P; Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland.; Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdańsk, Gdańsk, Poland.; BioTechMed Centre/Department of Mechanics of Materials and Structures, Gdańsk University of Technology, Gdańsk, Poland., Kalinowski L; Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland.; Department of Medical Laboratory Diagnostics-Fahrenheit Biobank BBMRI.pl, Medical University of Gdańsk, Gdańsk, Poland.; BioTechMed Centre/Department of Mechanics of Materials and Structures, Gdańsk University of Technology, Gdańsk, Poland., Galvan V; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; College of Medicine, Oklahoma Health Science Center, Oklahoma City, OK, USA.; Department of Biochemistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; South Texas VA Health Care System, San Antonio, TX, USA.; Oklahoma City VA Health Care System, Oklahoma City, OK, USA., Osmulski PA; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; Department of Molecular Medicine, UT Health San Antonio, San Antonio, TX, USA., Jankowska E; Department of Biomedical Chemistry, University of Gdańsk, Gdańsk, Poland., Gaczynska M; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; Department of Molecular Medicine, UT Health San Antonio, San Antonio, TX, USA., Pickering AM; Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; Department of Molecular Medicine, UT Health San Antonio, San Antonio, TX, USA.; Center for Neurodegeneration and Experimental Therapeutics (CNET), Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.

Publikováno v: Science advances [Sci Adv] 2022 Jun 10; Vol. 8 (23), pp. eabk2252. Date of Electronic Publication: 2022 Jun 08.

The Novel HDAC Inhibitor OBP-801 Promotes MHC Class I Presentation Through LMP2 Upregulation, Enhancing the PD-1-Targeting Therapy in Clear Cell Renal Cell Carcinoma.

Autor: Narukawa, Tsukasa^1,2 (AUTHOR) tnarukaw@koto.kpu-m.ac.jp, Yasuda, Shusuke¹ (AUTHOR) m-hori@koto.kpu-m.ac.jp, Horinaka, Mano¹ (AUTHOR) ktaniguc@koto.kpu-m.ac.jp, Taniguchi, Keiko¹ (AUTHOR) miemori@koto.kpu-m.ac.jp, Tsujikawa, Takahiro³ (AUTHOR) tu-ji@koto.kpu-m.ac.jp, Morita, Mie¹ (AUTHOR) tsakai@koto.kpu-m.ac.jp, Ukimura, Osamu² (AUTHOR), Sakai, Toshiyuki¹ (AUTHOR)

Publikováno v: Cancers. Dec2024, Vol. 16 Issue 23, p4058. 16p.

Bioinformatic-Experimental Screening Uncovers Multiple Targets for Increase of MHC-I Expression through Activating the Interferon Response in Breast Cancer.

Autor: Li, Xin¹ (AUTHOR), Ruan, Zilun¹ (AUTHOR), Yang, Shuzhen¹ (AUTHOR) lxin_z@whu.edu.cn, Yang, Qing¹ (AUTHOR), Li, Jinpeng¹ (AUTHOR) echo2024@whu.edu.cn, Hu, Mingming¹ (AUTHOR) echo2024@whu.edu.cn

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10546. 23p.