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Intratympanic Administration of OTO-313 Reduces Tinnitus in Patients With Moderate to Severe, Persistent Tinnitus: A Phase 1/2 Study

Autor: Kenneth S. Maxwell, Gordon McMurry, Jeffery J Anderson, Huiying J. Hou, David M. Baguley, Grant D. Searchfield, Ines Hoffmann, Fabrice Piu, James M Robinson

Publikováno v: Otology & Neurotology

Objective: To evaluate the safety and exploratory efficacy of intratympanic administration of OTO-313 in patients with tinnitus. Study Design: Single intratympanic injection of OTO-313 evaluated in a randomized, double-blind, placebo-controlled Phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d50feae90a93dbc6c01420ea4140490

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Advice on assistance and protection by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 2. On preventing and treating health effects from acute, prolonged, and repeated nerve agent exposure, and the identification of medical countermeasures able to reduce or eliminate the longer term health effects of nerve agents

Publikováno v: Toxicology. 413:13-23

The Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) has provided advice in relation to the Chemical Weapons Convention on assistance and protection. We present the SAB's response to a request from th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235fa84d565d06186009a1b21c66028b
https://doi.org/10.1016/j.tox.2018.11.009

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Akademický článek

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Characterization of ‘non-N-methyl-d-Aspartate’ binding sites for gacyclidine enantiomers in the rat cerebellar and telencephalic structures

Autor: Jean Marc Kamenka, Jacques Vignon, Hélène Hirbec, Alain Privat

Publikováno v: Journal of Neurochemistry. 77:190-201

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05371d6cc4abba090c4a28977032318e
https://doi.org/10.1046/j.1471-4159.2001.00250.x

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Neuroprotection From Soman-induced Seizures In The Rodent: Evaluation With Diffusion- And T2-weighted Magnetic Resonance Imaging

Autor: John Mikler, Murray G. Hamilton, Andre Obenaus, Edward J. Kendall, Yusuf A. Bhagat

Publikováno v: NeuroToxicology. 26:1001-1013

Exposure to the organophosphate nerve agent soman produces seizures that in turn lead to neuropathology. This study describes the temporal and spatial evolution of brain pathology following soman-induced convulsions and the attenuation of these alter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba1d5f602c08aa3153716f416dfe859
https://doi.org/10.1016/j.neuro.2005.04.006

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Current status of clinical trials for acute spinal cord injury

Autor: Michael G. Fehlings, Darryl C. Baptiste

Publikováno v: Injury. 36:S113-S122

Acute spinal cord injury (ASCI) occurs as a result of physical disruption of spinal cord axons through the epicenter of injury leading to deficits in motor, sensory, and autonomic function. This is a debilitating neurological disorder common in young

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b205947874b6f3f4d4a6bdc3ffd42a40
https://doi.org/10.1016/j.injury.2005.06.022

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Neuroprotective effect of gacyclidine: A multicenter double-blind pilot trial in patients with acute traumatic brain injury

Autor: J.-F. Lepeintre, J. Delcour, C. Kempf, P. D'arbigny, B. Vigué, M. Tadié, G. Loubert, J.-F. Mathé

Publikováno v: Neurochirurgie. 50:83-95

The aim of this study was to assess the safety and efficacy of intravenous (IV) injections of gacyclidine, a novel NMDA receptor antagonist, for neurological and functional recovery following acute traumatic brain injury. This multicenter, prospectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86614713e935ce7a6ca311345289e5c2
https://doi.org/10.1016/s0028-3770(21)00116-8

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Re-evaluation of phencyclidine low-affinity or ?non-NMDA? binding sites

Autor: Alain Privat, Jean Marc Kamenka, Anne-Laure Mausset, Jacques Vignon, Hélène Hirbec

Publikováno v: Journal of Neuroscience Research
Journal of Neuroscience Research, Wiley, 2002, 68 (3), pp.305-314. ⟨10.1002/jnr.10203⟩

TCP and its derivative gacyclidine (+/- GK11) are high-affinity non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors (NMDARs) and as such exhibit significant neuroprotective properties. These compounds also bind with a low affinity to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341bb1bf6551cce916ca7b80045d57b9
https://doi.org/10.1002/jnr.10203

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Altered mental status and end organ damage associated with the use of gacyclidine: a case series

Autor: Timothy E Albertson, Jonathan B. Ford, Samuel O. Clarke, Roy Gerona, Kelly P. Owen, Mark E. Sutter, James A. Chenoweth, John S. Rose

Publikováno v: Journal of medical toxicology : official journal of the American College of Medical Toxicology, vol 11, iss 1

IntroductionOver the past decade, there has been a sharp increase in the number of newly identified synthetic drugs. These new drugs are often derivatives of previously abused substances but have unpredictable toxicity. One of these drugs is gacyclid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdeb6baa0cbb26e4c2bd2108af9c95a
https://pubmed.ncbi.nlm.nih.gov/25048606

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