Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gaby, El Alam"'
Autor:
Arwen W. Gao, Gaby El Alam, Yunyun Zhu, Weisha Li, Jonathan Sulc, Xiaoxu Li, Elena Katsyuba, Terytty Y. Li, Katherine A. Overmyer, Amelia Lalou, Laurent Mouchiroud, Maroun Bou Sleiman, Matteo Cornaglia, Jean-David Morel, Riekelt H. Houtkooper, Joshua J. Coon, Johan Auwerx
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114836- (2024)
Summary: Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determin
Externí odkaz:
https://doaj.org/article/f30f2e821b914d2aa267921774dc8718
Autor:
Ece Yildiz, Gaby El Alam, Alessia Perino, Antoine Jalil, Pierre-Damien Denechaud, Katharina Huber, Lluis Fajas, Johan Auwerx, Giovanni Sorrentino, Kristina Schoonjans
Publikováno v:
eLife, Vol 12 (2023)
During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of c
Externí odkaz:
https://doaj.org/article/bf974a9e806e4f7d9bbe3cfeee9224d3
Autor:
Adrienne Mottis, Terytty Y. Li, Gaby El Alam, Alexis Rapin, Elena Katsyuba, David Liaskos, Davide D’Amico, Nicola L. Harris, Mark C. Grier, Laurent Mouchiroud, Mark L. Nelson, Johan Auwerx
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
Mitohormesis defines the increase in fitness mediated by adaptive responses to mild mitochondrial stress. Tetracyclines inhibit not only bacterial but also mitochondrial translation, thus imposing a low level of mitochondrial stress on eukaryotic cel
Externí odkaz:
https://doaj.org/article/640bce408e454dcb9f479983b78136ee
Autor:
Alexis Maximilien Bachmann, Jean-David Morel, Gaby El Alam, Sandra Rodríguez-López, Tanes Imamura de lima, Ludger J.E. Goeminne, Giorgia Benegiamo, Sylvain Loric, Marc Conti, Maroun Bou Sleiman, Johan Auwerx
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104468- (2022)
Summary: The sharp increase in obesity prevalence worldwide is mainly attributable to changes in physical activity and eating behavior but the metabolic and clinical impacts of these obesogenic conditions vary between sexes and genetic backgrounds. T
Externí odkaz:
https://doaj.org/article/2c2e4f4c87774adbab3ccd8960b7f742
Autor:
Arwen W. Gao, Gaby El Alam, Amélia Lalou, Terytty Yang Li, Marte Molenaars, Yunyun Zhu, Katherine A. Overmyer, Evgenia Shishkova, Kevin Hof, Maroun Bou Sleiman, Riekelt H. Houtkooper, Joshua J. Coon, Johan Auwerx
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103734- (2022)
Summary: The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging and age-related diseases. However, the integrative analysis of the impact of UPRmt activation on different signaling layers in animals with d
Externí odkaz:
https://doaj.org/article/bacd3afe777e47c39fb1890b101a8dd9
Autor:
Ece Yildiz, Gaby El Alam, Alessia Perino, Antoine Jalil, Pierre-Damien Denechaud, Katharina Huber, Lluis Fajas, Johan Auwerx, Giovanni Sorrentino, Kristina Schoonjans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::323fffe29a55603df62e87fb944bf2fb
https://doi.org/10.7554/elife.81926.sa2
https://doi.org/10.7554/elife.81926.sa2
Autor:
Alexis Maximilien Bachmann, Terytty Yang Li, Hao Li, Adrienne Mottis, Arwen W. Gao, Johan Auwerx, Ludger J. E. Goeminne, Kristina Schoonjans, Gaby El Alam, Xiaoxu Li, Maroun Bou Sleiman
Publikováno v:
Nature aging
Organisms respond to mitochondrial stress by activating multiple defense pathways including the mitochondrial unfolded protein response (UPRmt). However, how UPRmt regulators are orchestrated to transcriptionally activate stress responses remains lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5bcec9ad1323386098553aa5d939ed
https://doi.org/10.1038/s43587-020-00025-z
https://doi.org/10.1038/s43587-020-00025-z
Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mice
Autor:
Alexis Maximilien Bachmann, Jean-David Morel, Gaby El Alam, Sandra Rodríguez-López, Tanes Imamura de lima, Ludger J.E. Goeminne, Giorgia Benegiamo, Maroun Bou Sleiman, Johan Auwerx
Overweight and obesity are increasingly common public health issues worldwide, leading to a wide range of diseases from metabolic syndrome to steatohepatitis and cardiovascular diseases. While the increase in the prevalence of obesity is partly attri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77e268b9b0676ef15bdb799059a35d1f
https://doi.org/10.1101/2021.09.02.458729
https://doi.org/10.1101/2021.09.02.458729
Autor:
Arwen W, Gao, Gaby, El Alam, Amélia, Lalou, Terytty Yang, Li, Marte, Molenaars, Yunyun, Zhu, Katherine A, Overmyer, Evgenia, Shishkova, Kevin, Hof, Maroun, Bou Sleiman, Riekelt H, Houtkooper, Joshua J, Coon, Johan, Auwerx
Publikováno v:
iScience
Summary The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging and age-related diseases. However, the integrative analysis of the impact of UPRmt activation on different signaling layers in animals with di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::978c69ff762e1ca2e9f777960d155f12
https://pubmed.ncbi.nlm.nih.gov/35118355
https://pubmed.ncbi.nlm.nih.gov/35118355
Autor:
Giovanni Sorrentino, Maroun Bou Sleiman, Roberto Pellicciari, Gaby El Alam, Antimo Gioiello, Alessia Perino, Ece Yildiz, Kristina Schoonjans
Publikováno v:
Gastroenterology. 159:956-968.e8
BACKGROUND & AIMS: Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f84590373b59a6f9cc3b60993f6c6e4
https://doi.org/10.1053/j.gastro.2020.05.067
https://doi.org/10.1053/j.gastro.2020.05.067