Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gabrielle St-Pierre"'
Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor
Autor:
Liang Zhang, Daniel J. Griffin, Matthew G. Beaver, Laura E. Blue, Christopher J. Borths, Derek B. Brown, Seb Caille, Ying Chen, Alan H. Cherney, Brian M. Cochran, John T. Colyer, Michael T. Corbett, Tiffany L. Correll, Richard D. Crockett, Xi-Jie Dai, Peter K. Dornan, Robert P. Farrell, Simon J. Hedley, Hsiao-Wu Hsieh, Liang Huang, Seth Huggins, Min Liu, Michael A. Lovette, Kyle Quasdorf, William Powazinik, Jonathan Reifman, Jo Anna Robinson, Rahul P. Sangodkar, Sonika Sharma, Srividya Sharvan Kumar, Austin G. Smith, Gabrielle St-Pierre, Jason S. Tedrow, Oliver R. Thiel, Jonathan V. Truong, Shawn D. Walker, Carolyn S. Wei, Ashraf Wilsily, Yong Xie, Ning Yang, Andrew T. Parsons
Publikováno v:
Organic Process Research & Development. 26:3115-3125
Autor:
Elçin Içten, Seb Caille, Gabrielle St-Pierre, Oliver R. Thiel, Sharon E. Michalak, Matthew G. Beaver
Publikováno v:
Israel Journal of Chemistry. 61:369-379
Publikováno v:
Synthesis. 48:3575-3588
Adopting the ‘remote activation concept’ toward stereocontrolled glycoside synthesis with minimal use of protection groups, a general synthesis of phenolic 1,2- cis glycopyranosides is reported, as exemplified by aryl α- d -galacto-, α- d -gluc
Autor:
Stephen Hanessian, Gabrielle St-Pierre, Tianyuan Zhou, Sudip Pal, Michael E. Østergaard, Jinghua Yu, Punit P. Seth, Michael Tanowitz
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2397-2409
Antisense oligonucleotides (ASOs) modified with ligands which target cell surface receptors have the potential to significantly improve potency in the target tissue. This has recently been demonstrated using triantennary N-acetyl d-galactosamine conj
Publikováno v:
Tetrahedron. 71:709-726
Reported herein is the total synthesis of zincophorin methyl ester, a polyketide ionophore. Of particular interest is the use of sterically hindered nucleophiles to surmount the unfavorable stereochemical outcome, leading to acetate aldol adducts, in
Autor:
Mickael Calosso, Yvan Guindon, Gabrielle St-Pierre, Michel Prévost, Guillaume Tambutet, Marc Vaillancourt, Jean-Philippe Gratton, Daniel Charpentier, Mohammed Bencheqroun
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1054-1059
We report on the design and synthesis of molecules having E- and P-selectins blocking activity both in vitro and in vivo. The GlcNAc component of the selectin ligand sialyl Lewis(X) was replaced by an acyclic tether that links two saccharide units. T
Autor:
Yvan Guindon, Mohammed Bencheqroun, Marc Vaillancourt, Mickael Calosso, Daniel Charpentier, Brian C. Wilkes, Gabrielle St-Pierre
Publikováno v:
ACS Medicinal Chemistry Letters. 3:1045-1049
The discovery of molecules that interfere with the binding of a ligand to a receptor remains a topic of great interest in medicinal chemistry. Herein, we report that a monosaccharide unit of a polysaccharide ligand can be replaced advantageously by a