Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gabrielle S Le Provost"'
Autor:
Jane Harper, Katherine J Adams, Giovanna Bossi, Debbie E Wright, Andrea R Stacey, Nicole Bedke, Ruth Martinez-Hague, Dan Blat, Laure Humbert, Hazel Buchanan, Gabrielle S Le Provost, Zoe Donnellan, Ricardo J Carreira, Samantha J Paston, Luise U Weigand, Martina Canestraro, Joseph P Sanderson, Sophie Botta Gordon-Smith, Kate L Lowe, Karolina A Rygiel, Alex S Powlesland, Annelise Vuidepot, Namir J Hassan, Brian J Cameron, Bent K Jakobsen, Joseph Dukes
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205491 (2018)
Robust preclinical testing is essential to predict clinical safety and efficacy and provide data to determine safe dose for first-in-man studies. There are a growing number of examples where the preclinical development of drugs failed to adequately p
Externí odkaz:
https://doaj.org/article/c3d7165394b5442098ed39f7073a5fbd
Autor:
Caroline Reynaud, Jacques Pouysségur, Pascal Sommer, Philippe Clézardin, Blandine Deux, Gabrielle S. Le Provost, Géraldine Aimond, Bastien Kaniewski, Jérome Durivault, Frédéric Dayan, Floriane Pez
Supplementary Figure 3 from The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce74cfc26638925ec7ad756e2ed40a15
https://doi.org/10.1158/0008-5472.22388160.v1
https://doi.org/10.1158/0008-5472.22388160.v1
Autor:
Caroline Reynaud, Jacques Pouysségur, Pascal Sommer, Philippe Clézardin, Blandine Deux, Gabrielle S. Le Provost, Géraldine Aimond, Bastien Kaniewski, Jérome Durivault, Frédéric Dayan, Floriane Pez
Supplementary Legends for Figures 1-4 from The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcaf9efdbfd75c403ec4cc6d165c761
https://doi.org/10.1158/0008-5472.22388154.v1
https://doi.org/10.1158/0008-5472.22388154.v1
Autor:
Caroline Reynaud, Jacques Pouysségur, Pascal Sommer, Philippe Clézardin, Blandine Deux, Gabrielle S. Le Provost, Géraldine Aimond, Bastien Kaniewski, Jérome Durivault, Frédéric Dayan, Floriane Pez
Supplementary Figure 1 from The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bda01ba3e698244f7966bf10ab6514a
https://doi.org/10.1158/0008-5472.22388166
https://doi.org/10.1158/0008-5472.22388166
Autor:
Caroline Reynaud, Jacques Pouysségur, Pascal Sommer, Philippe Clézardin, Blandine Deux, Gabrielle S. Le Provost, Géraldine Aimond, Bastien Kaniewski, Jérome Durivault, Frédéric Dayan, Floriane Pez
Supplementary Figure 4 from The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bf8ca300ed68487445fed85090dbca
https://doi.org/10.1158/0008-5472.22388157
https://doi.org/10.1158/0008-5472.22388157
Autor:
Caroline Reynaud, Jacques Pouysségur, Pascal Sommer, Philippe Clézardin, Blandine Deux, Gabrielle S. Le Provost, Géraldine Aimond, Bastien Kaniewski, Jérome Durivault, Frédéric Dayan, Floriane Pez
Supplementary Methods from The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d34ae293da5cc72193994ec60336e85
https://doi.org/10.1158/0008-5472.22388151
https://doi.org/10.1158/0008-5472.22388151
Autor:
Jane Houghton, Laura Collins, Koustubh Ranade, Adel Benlahrech, Gabrielle S. Le Provost, Camille Britton-Rivet, Jane Harper, David Depoil, Mariantonella Vardeu
Publikováno v:
Regular and young investigator award abstracts.
Background Tebentafusp (IMCgp100) is a bispecific T cell redirector comprised of an affinity-enhanced TCR recognising melanocyte lineage antigen gp100 and a T cell engaging anti-CD3 scFv domain. Tebentafusp has shown activity as monotherapy in advanc
Autor:
Florence Schlosser, Laure Humbert, Gabrielle S. Le Provost, Amanda M. Williams, Jane Harper, Jacob Robinson, Greg Dobrynin, Alessio Vantellini, Sylvie Moureau, Athiva Shankar, David Berman
Publikováno v:
Cancer Research. 80:5572-5572
Background: Bispecific immunotherapies have been validated for the treatment of hematologic tumors but none have yet been approved for solid tumor indications, including high prevalent tumors such as non-small-cell lung carcinoma (NSCLC). Immunocore
Autor:
Pascal Sommer, Valerie Andre, Valerie Cenizo, Gabrielle S. Le Provost, Géraldine Aimond, Bastien Kaniewski, Floriane Pez, Romain Debret
Publikováno v:
Experimental Dermatology. 19:1080-1087
Lysyl Oxidase (LOX) is an extracellular enzyme involved in the maturation of connective tissues. It also acts in many cell types as a regulator of cell behaviour and phenotype through intracellular signalling pathways. Recently, LOX was shown to be p
Autor:
Marine C C Raman, Pierre J Rizkallah, Ruth Simmons, Zoe Donnellan, Joseph Dukes, Giovanna Bossi, Gabrielle S Le Provost, Penio Todorov, Emma Baston, Emma Hickman, Tara Mahon, Namir Hassan, Annelise Vuidepot, Malkit Sami, David K Cole, Bent K. Jakobsen
Publikováno v:
Scientific Reports
Natural T-cell responses generally lack the potency to eradicate cancer. Enhanced affinity T-cell receptors (TCRs) provide an ideal approach to target cancer cells, with emerging clinical data showing significant promise. Nevertheless, the risk of of