Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Gabrielle Romain"'
Autor:
Gabrielle Romain, Paolo Strati, Ali Rezvan, Mohsen Fathi, Irfan N. Bandey, Jay R T. Adolacion, Darren Heeke, Ivan Liadi, Mario L. Marques-Piubelli, Luisa M. Solis, Ankit Mahendra, Francisco Vega, Laurence J.N. Cooper, Harjeet Singh, Mike Mattie, Adrian Bot, Sattva S. Neelapu, Navin Varadarajan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
The in vivo persistence of adoptively transferred T cells is predictive of antitumor response. Identifying functional properties of infused T cells that lead to in vivo persistence and tumor eradication has remained elusive. We profiled CD19-specific
Externí odkaz:
https://doaj.org/article/22541142eb294d1693d8dcd42d53759f
Autor:
Navin Varadarajan, Ivan Liadi, Gabrielle Romain, Harjeet Singh, Arash Saeedi, Irfan N Bandey, Jay R T Adolacion, Melisa Martinez Paniagua, Xingyue An, Zheng You, Rasindu B Rajanayake, Laurence JN Cooper
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Adoptive cell therapy based on the infusion of chimeric antigen receptor (CAR) T cells has shown remarkable efficacy for the treatment of hematologic malignancies. The primary mechanism of action of these infused T cells is the direct kill
Externí odkaz:
https://doaj.org/article/0fec376a934743aab514c14f56cef78e
Autor:
Ivan Liadi, Harjeet Singh, Gabrielle Romain, Badrinath Roysam, Laurence JN Cooper, Navin Varadarajan
Publikováno v:
OncoImmunology, Vol 8, Iss 10 (2019)
Genetically engineered T cells that express chimeric antigen receptors (CAR+) are heterogeneous and thus, understanding the immunotherapeutic efficacy remains a challenge in adoptive cell therapy. We developed a high-throughput single-cell methodolog
Externí odkaz:
https://doaj.org/article/509c577877f84025b9ca1dc82079ddc6
Autor:
Xingyue An, Victor G Sendra, Ivan Liadi, Balakrishnan Ramesh, Gabrielle Romain, Cara Haymaker, Melisa Martinez-Paniagua, Yanbin Lu, Laszlo G Radvanyi, Badrinath Roysam, Navin Varadarajan
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181904 (2017)
Natural killer (NK) cells are a highly heterogeneous population of innate lymphocytes that constitute our first line of defense against several types of tumors and microbial infections. Understanding the heterogeneity of these lymphocytes requires th
Externí odkaz:
https://doaj.org/article/472797aefabb4ff6b234b3beee328903
Autor:
Navin Varadarajan, Laurence J.N. Cooper, Badrinath Roysam, Peng Qiu, Helen Huls, Partow Kebriaei, Jay R T. Adolacion, Amine Merouane, Nicolas Rey-Villamizar, Gabrielle Romain, Harjeet Singh, Ivan Liadi
Table ST1: Glossary of terms used in the paper Figure S1. Genetic modification and expansion of CAR+ T cells. Figure S2. In vitro expansion of CAR+ T cells. Figure S3. High-throughput cytotoxicity assay for monitoring T-cell target cell interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60afe1510f0bd4105214cbdbec6194d2
https://doi.org/10.1158/2326-6066.22538110
https://doi.org/10.1158/2326-6066.22538110
Autor:
Navin Varadarajan, Laurence J.N. Cooper, Badrinath Roysam, Peng Qiu, Helen Huls, Partow Kebriaei, Jay R T. Adolacion, Amine Merouane, Nicolas Rey-Villamizar, Gabrielle Romain, Harjeet Singh, Ivan Liadi
T cells genetically modified to express a CD19-specific chimeric antigen receptor (CAR) for the investigational treatment of B-cell malignancies comprise a heterogeneous population, and their ability to persist and participate in serial killing of tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc15c424cb4efaa00fc07257b25c7021
https://doi.org/10.1158/2326-6066.c.6548665.v1
https://doi.org/10.1158/2326-6066.c.6548665.v1
Autor:
Navin Varadarajan, Laurence J.N. Cooper, Badrinath Roysam, Peng Qiu, Helen Huls, Partow Kebriaei, Jay R T. Adolacion, Amine Merouane, Nicolas Rey-Villamizar, Gabrielle Romain, Harjeet Singh, Ivan Liadi
Movie M4. Representative example of a CAR8 cell that kills multiple tumor cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fb9aaa706bbe3306332a426bf97ef7
https://doi.org/10.1158/2326-6066.22538098
https://doi.org/10.1158/2326-6066.22538098
Autor:
Navin Varadarajan, Laurence J.N. Cooper, Badrinath Roysam, Peng Qiu, Helen Huls, Partow Kebriaei, Jay R T. Adolacion, Amine Merouane, Nicolas Rey-Villamizar, Gabrielle Romain, Harjeet Singh, Ivan Liadi
Movie M1. Representative example of a CAR8 cell from the S1 subgroup.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52aeff0aee1d7d6209fedd9391c10b18
https://doi.org/10.1158/2326-6066.22538107.v1
https://doi.org/10.1158/2326-6066.22538107.v1
Autor:
Navin Varadarajan, Laurence J.N. Cooper, Badrinath Roysam, Peng Qiu, Helen Huls, Partow Kebriaei, Jay R T. Adolacion, Amine Merouane, Nicolas Rey-Villamizar, Gabrielle Romain, Harjeet Singh, Ivan Liadi
Movie M3. Representative example of a CAR8 cell from the S3 subgroup.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20126b627b26d8ae31ac7881cf989170
https://doi.org/10.1158/2326-6066.22538101
https://doi.org/10.1158/2326-6066.22538101
Autor:
Navin Varadarajan, Laurence J.N. Cooper, Badrinath Roysam, Peng Qiu, Helen Huls, Partow Kebriaei, Jay R T. Adolacion, Amine Merouane, Nicolas Rey-Villamizar, Gabrielle Romain, Harjeet Singh, Ivan Liadi
Movie M5. Representative example of a CAR4 cell that kills multiple tumor cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499f35a1a764c6cf0b61deb2a4b34d0a
https://doi.org/10.1158/2326-6066.22538095.v1
https://doi.org/10.1158/2326-6066.22538095.v1