Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations

Autor: Jennifer R. Habel, Brendon Y. Chua, Lukasz Kedzierski, Kevin J. Selva, Timon Damelang, Ebene R. Haycroft, Thi H.O. Nguyen, Hui-Fern Koay, Suellen Nicholson, Hayley A. McQuilten, Xiaoxiao Jia, Lilith F. Allen, Luca Hensen, Wuji Zhang, Carolien E. van de Sandt, Jessica A. Neil, Katherine Pragastis, Jillian S.Y. Lau, Jaycee Jumarang, E. Kaitlynn Allen, Fatima Amanant, Florian Krammer, Kathleen M. Wragg, Jennifer A. Juno, Adam K. Wheatley, Hyon-Xhi Tan, Gabrielle Pell, Susan Walker, Jennifer Audsley, Arnold Reynaldi, Irani Thevarajan, Justin T. Denholm, Kanta Subbarao, Miles P. Davenport, P. Mark Hogarth, Dale I. Godfrey, Allen C. Cheng, Steven Y.C. Tong, Katherine Bond, Deborah A. Williamson, James H. McMahon, Paul G. Thomas, Pia S. Pannaraj, Fiona James, Natasha E. Holmes, Olivia C. Smibert, Jason A. Trubiano, Claire L. Gordon, Amy W. Chung, Clare L. Whitehead, Stephen J. Kent, Martha Lappas, Louise C. Rowntree, Katherine Kedzierska

Publikováno v: JCI Insight, Vol 8, Iss 7 (2023)

Pregnancy poses a greater risk for severe COVID-19; however, underlying immunological changes associated with SARS-CoV-2 during pregnancy are poorly understood. We defined immune responses to SARS-CoV-2 in unvaccinated pregnant and nonpregnant women

Externí odkaz: https://doaj.org/article/5baf2d86cad54efcaef6a7913823280a

Pre-eclampsia is associated with altered expression of the renal sodium transporters NKCC2, NCC and ENaC in urinary extracellular vesicles.

Autor: Chih-Chiang Hu, Marina Katerelos, Suet-Wan Choy, Amy Crossthwaite, Susan P Walker, Gabrielle Pell, Mardiana Lee, Natasha Cook, Peter F Mount, Kathy Paizis, David A Power

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0204514 (2018)

Pre-eclampsia is a hypertensive disorder of pregnancy characterised by hypertension and sodium retention by the kidneys. To identify changes in sodium uptake proteins in the tubules of the distal nephron, we studied their expression in urinary extrac

Externí odkaz: https://doaj.org/article/42b73b64616e45349018e62116dcde0b

Multimedia in improving informed consent for caesarean section: A randomised controlled trial

Autor: Alice Truong, Lauren Hicks, Susan P. Walker, Lenore Ellett, Gabrielle Pell

Publikováno v: Australian and New Zealand Journal of Obstetrics and Gynaecology. 60:683-689

BACKGROUND: Multimedia modules have been used as an adjunct to improve patient knowledge and recall for various elective surgical procedures, but have been incompletely evaluated in patients undergoing caesarean section. AIMS: To compare the use of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f9f42fa532da4a51eede2425aa2177
https://doi.org/10.1111/ajo.13124

Integrated immune networks in SARS-CoV-2 infected pregnant women reveal differential NK cell and unconventional T cell activation

Autor: Jennifer A Juno, Allen C. Cheng, Stephen J. Kent, Steven Y. C. Tong, Katherine Bond, Thi H. O. Nguyen, Jennifer R. Habel, Hui-Fern Koay, Jennifer Audsley, Kevin J. Selva, Florian Krammer, Adam K. Wheatley, Wuji Zhang, Kanta Subbarao, Clare Whitehead, Suellen Nicholson, Xiaoxiao Jia, Hayley A McQuilten, Katherine Kedzierska, Amy A Chung, Luca Hensen, Kathleen M. Wragg, Lilith F. Allen, Natasha E Holmes, Fiona L James, Ebene R. Haycroft, Louise C. Rowntree, Hyon-Xhi Tan, Jessica A. Neil, Gabrielle Pell, Jason A Trubiano, Timon Damelang, Claire L. Gordon, Olivia C Smibert, Irani Thevarajan, Justin T Denholm, Dale I. Godfrey, Fatima Amanat, Lukasz Kedzierski, Carolien E. van de Sandt, Martha Lappas, Brendon Y. Chua, Deborah A Williamson

Although pregnancy poses a greater risk for severe COVID-19, the underlying immunological changes associated with SARS-CoV-2 infection during pregnancy are poorly understood. We defined immune responses to SARS-CoV-2 in pregnant and non-pregnant wome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4060f55498230fdc44d4015ddd235a5
https://doi.org/10.21203/rs.3.rs-745648/v1

Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria

Autor: Jessica Jellins, Tess Cruickshank, Manju Kandel, Damanpreet Garcha, Ciara Murphy, Carole Anne Whigham, Stephen Tong, Gabrielle Pell, Sebastian E. Illanes, Susan P. Walker, Jenny Myers, Emerson Keenan, Georgia P. Wong, Anna Middleton, Joshua Masci, Alexandra Roddy Mitchell, Natasha Pritchard, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino, Jon Hyett, Natalie J. Hannan, Tuong-Vi Nguyen, Teresa M. MacDonald, Manuel Schepeler, Elizabeth Murray, Fiona C Brownfoot, Jhy K. Nien

Publikováno v: Garcha, D, Walker, S P, MacDonald, T M, Hyett, J, Jellins, J, Myers, J, Illanes, S E, Nien, J K, Schepeler, M, Keenan, E, Whigham, C-A, Cannon, P, Murray, E, Nguyen, T-V, Kandel, M, Masci, J, Murphy, C, Cruickshank, T, Pritchard, N, Hannan, N J, Brownfoot, F, Roddy Mitchell, A, Middleton, A, Pell, G, Wong, G P, Tong, S & Kaitu’u-Lino, T J 2021, ' Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria ', Scientific Reports, vol. 11, no. 1, 16595 . https://doi.org/10.1038/s41598-021-96077-1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy. Identifying novel biomarkers may improve detection of pregnancies at risk. This study aimed to assess syndecan-1 as a biomarker for small for ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acf66776a728a419487abe22c6fb99c
https://doi.org/10.1038/s41598-021-96077-1