Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gabrielle K. Crombie"'
Autor:
Julia C. Shaw, Rebecca M. Dyson, Hannah K. Palliser, Gabrielle K. Crombie, Mary J. Berry, Jonathan J. Hirst
Publikováno v:
Reproductive Medicine, Vol 3, Iss 2, Pp 85-100 (2022)
(Background) The transition from in utero to ex utero life is associated with rapid changes in the brain that are both protective and required for newborn functional activities, allowing adaption to the changing environment. The current study aimed t
Externí odkaz:
https://doaj.org/article/f76b0807f0ab45199fd91d04f164fe13
Autor:
Julia C. Shaw, Rebecca M. Dyson, Hannah K. Palliser, Ryan P. Sixtus, Heather Barnes, Carlton L. Pavy, Gabrielle K. Crombie, Mary J. Berry, Jonathan J. Hirst
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background: Preterm birth can lead to brain injury and currently there are no targeted therapies to promote postnatal brain development and protect these vulnerable neonates. We have previously shown that the neurosteroid-analogue ganaxolone promotes
Externí odkaz:
https://doaj.org/article/ae081f984fe74959823907bbff628522
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Preterm birth is associated with poor long-term neurodevelopmental and behavioral outcomes, even in the absence of obvious brain injury at the time of birth. In particular, behavioral disorders characterized by inattention, social difficulties and an
Externí odkaz:
https://doaj.org/article/d1b4e03f66434bdeb754b1e50f26b39b
Autor:
Julia C. Shaw, Mary J. Berry, Rebecca M. Dyson, Gabrielle K. Crombie, Jonathan J. Hirst, Hannah K. Palliser
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Children born preterm are at an increased risk of developing cognitive problems and neuro-behavioral disorders such as attention deficit hyperactivity disorder (ADHD) and anxiety. Whilst neonates born at all gestational ages, even at term, can experi
Externí odkaz:
https://doaj.org/article/619c0aa28ac24e3b945449a022b86bb5
Autor:
Gabrielle K. Crombie, Hannah K. Palliser, Julia C Shaw, Bethany A Hanley, Roisin A Moloney, Jonathan J. Hirst
Publikováno v:
Developmental Neuroscience.
Background: Disruptions to neurodevelopment is known to be linked to behavioural disorders in childhood and into adulthood. The fetal brain is extremely vulnerable to stimuli that alter inhibitory GABAergic pathways and critical myelination processes
Autor:
Gabrielle K, Crombie, Hannah K, Palliser, Julia C, Shaw, Deborah M, Hodgson, David W, Walker, Jonathan J, Hirst
Publikováno v:
Psychoneuroendocrinology. 139:105705
A correct balance of activity of the GABA and glutamate systems is vital for optimal neurodevelopment and general CNS function, and the dysregulation of this balance has been implicated in a number of neurological conditions. Maternal exposure to str
Autor:
Jonathan J. Hirst, Julia C. Shaw, David W. Walker, Hannah K. Palliser, Gabrielle K. Crombie, Deborah M. Hodgson
Publikováno v:
Psychoneuroendocrinology. 124
Background Chronic psychosocial stress during pregnancy and/or after birth, and the associated elevation in cortisol, is linked with the onset of behavioural disorders in childhood. Previously, prenatal stress has been shown to reduce neurosteroid pa
Publikováno v:
Journal of Neuroendocrinology. 32
Extensive evidence now shows that adversity during the perinatal period is a significant risk factor for the development of neurodevelopmental disorders long after the causative event. Despite stemming from a variety of causes, perinatal compromise a
Autor:
Jonathan J. Hirst, David W. Walker, Deborah M. Hodgson, Julia C. Shaw, Gabrielle K. Crombie, Hannah K. Palliser
Publikováno v:
Psychoneuroendocrinology. 133:105423
Background Prenatal stress is associated with long-term disturbances in white matter development and behaviour in children, such as attention deficit hyperactivity disorder (ADHD) and anxiety. Oligodendrocyte maturation and myelin formation is a tigh
Autor:
Jonathan J. Hirst, Angela L. Cumberland, Hannah K. Palliser, Gabrielle K. Crombie, David W. Walker
Publikováno v:
International Journal of Developmental Neuroscience. 58:50-58
Neurosteroids are essential for aiding proper fetal neurodevelopment. Pregnancy compromises such as preterm birth, prenatal stress and intrauterine growth restriction are associated with an increased risk of developing behavioural and mood disorders,