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pro vyhledávání: '"Gabrielle J. Valles"'
Publikováno v:
Data in Brief, Vol 34, Iss , Pp 106680- (2021)
This data article is related to the publication ‘DNA polymerase ι interacts with both the TRAF-like and UBL1-2 domains of USP7’ [1]. Ubiquitin-specific protease 7 (USP7) is an essential deubiquitinating enzyme with characterized substrates in ma
Externí odkaz:
https://doaj.org/article/0642d779e71e4311b34026aac0252ec5
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Genetic alterations, including DNA mutations and chromosomal abnormalities, are primary drivers of tumor formation and cancer progression. These alterations can endow cells with a selective growth advantage, enabling cancers to evade cell death, prol
Externí odkaz:
https://doaj.org/article/bea622e1818d4f25b9c0385806f6b6fb
Publikováno v:
bioRxiv
Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme responsible for the regulation of key human oncoproteins and tumor suppressors including Mdm2 and p53, respectively. Unlike other members of the USP family of proteases, the isolated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bd6578862ed77b52a0bbc2951cb5c4
https://europepmc.org/articles/PMC9882073/
https://europepmc.org/articles/PMC9882073/
Publikováno v:
Data in Brief, Vol 34, Iss, Pp 106680-(2021)
Data in Brief
Data in Brief
This data article is related to the publication 'DNA polymerase ι interacts with both the TRAF-like and UBL1-2 domains of USP7' [1]. Ubiquitin-specific protease 7 (USP7) is an essential deubiquitinating enzyme with characterized substrates in many c
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Genetic alterations, including DNA mutations and chromosomal abnormalities, are primary drivers of tumor formation and cancer progression. These alterations can endow cells with a selective growth advantage, enabling cancers to evade cell death, prol
Publikováno v:
Journal of molecular biology
Reversible protein ubiquitination is an essential signaling mechanism within eukaryotes. Deubiquitinating enzymes are critical to this process, as they mediate removal of ubiquitin from substrate proteins. Ubiquitin-specific protease 7 (USP7) is a pr
Publikováno v:
Biophysical Journal. 116:470a
USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms
Autor:
Joseph Weinstock, K. G. Suresh Kumar, Feng Wang, Jean Kanyo, Phuong H. Nguyen, Dennis L. Wright, Gabrielle J. Valles, Irina Bezsonova, Alexandra Pozhidaeva, David E. Sterner, Jian Wu
Publikováno v:
Cell Chemical Biology. 24:1501-1512.e5
USP7 is a deubiquitinating enzyme that plays a pivotal role in multiple oncogenic pathways and therefore is a desirable target for new anti-cancer therapies. However, the lack of structural information about the USP7-inhibitor interactions has been a