Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gabrielle J, Grundy"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
A critical risk factor for head and neck squamous cell carcinoma (HNSCC), particularly of the oropharynx, and the response to radiotherapy is human papillomavirus (HPV) type-16/18 infection. Specifically, HPV-positive HNSCC display increased radiosen
Externí odkaz:
https://doaj.org/article/9bd37a3457fb4af39891aba90f136d8c
Autor:
Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of
Externí odkaz:
https://doaj.org/article/f4adc148d44f418d9df058242e7f3bd6
Autor:
Gabrielle J. Grundy, Stuart L. Rulten, Raquel Arribas-Bosacoma, Kathryn Davidson, Zuzanna Kozik, Antony W. Oliver, Laurence H. Pearl, Keith W. Caldecott
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DN
Externí odkaz:
https://doaj.org/article/f76baaf3e5cb4dc5b122d503eff9616e
Autor:
Jason L. Parsons, Gabrielle J. Grundy
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2dadc4cd0861bba56cd90e25a7398ac
https://doi.org/10.1016/b978-0-12-821618-7.00100-0
https://doi.org/10.1016/b978-0-12-821618-7.00100-0
Autor:
Gabrielle J. Grundy, Jason L. Parsons
Publikováno v:
GUARDIANS OF THE GENOME: DNA DAMAGE AND REPAIR
Base excision repair (BER) has evolved to preserve the integrity of DNA following cellular oxidative stress and in response to exogenous insults. The pathway is a coordinated, sequential process involving 30 proteins or more in which single strand br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa45fb50740f68e2bca5bc9e697053c1
Publikováno v:
DNA Repair. 17:30-38
The repair of DNA double strand breaks is essential for cell survival and several conserved pathways have evolved to ensure their rapid and efficient repair. The non-homologous end joining pathway is initiated when Ku binds to the DNA break site. Ku
Autor:
Gabrielle J, Grundy, Luis M, Polo, Zhihong, Zeng, Stuart L, Rulten, Nicolas C, Hoch, Pathompong, Paomephan, Yingqi, Xu, Steve M, Sweet, Alan W, Thorne, Antony W, Oliver, Steve J, Matthews, Laurence H, Pearl, Keith W, Caldecott
Publikováno v:
Nature communications. 7
PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal that PARP3 employs a conserved
Publikováno v:
Proceedings of the National Academy of Sciences. 107:22487-22492
Gene assembly of the variable domain of antigen receptors is initiated by DNA cleavage by the RAG1–RAG2 protein complex at sites flanking V, D, and J gene segments. Double-strand breaks are produced via a single-strand nick that is converted to a h
Publikováno v:
The Journal of Immunology. 181:7825-7834
VH replacement is a form of IgH chain receptor editing that is believed to be mediated by recombinase cleavage at cryptic recombination signal sequences (cRSS) embedded in VH genes. Whereas there are several reports of VH replacement in primary and t
Publikováno v:
Proceedings of the National Academy of Sciences. 104:3078-3083
The rearrangement of antigen receptor genes is initiated by double-strand breaks catalyzed by the RAG1/2 complex at the junctions of recombination signal sequences and coding segments. As with some “cut-and-paste” transposases, such as Tn5 and He