Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gabrielle Heilek-Snyder"'
Autor:
Monique Nijhuis, Noortje M van Maarseveen, Stephane Lastere, Pauline Schipper, Eoin Coakley, Bärbel Glass, Mirka Rovenska, Dorien de Jong, Colombe Chappey, Irma W Goedegebuure, Gabrielle Heilek-Snyder, Dominic Dulude, Nick Cammack, Lea Brakier-Gingras, Jan Konvalinka, Neil Parkin, Hans-Georg Kräusslich, Francoise Brun-Vezinet, Charles A B Boucher
Publikováno v:
PLoS Medicine, Vol 4, Iss 1, p e36 (2007)
BACKGROUND: HIV protease inhibitor (PI) therapy results in the rapid selection of drug resistant viral variants harbouring one or two substitutions in the viral protease. To combat PI resistance development, two approaches have been developed. The fi
Externí odkaz:
https://doaj.org/article/9b249d2a4df84827a9f40807268dca47
Autor:
Tom Melby, Prakash R. Sista, N. Roberts, Gabrielle Heilek-Snyder, T J Matthews, T. Kirkland, Michael L. Greenberg, Ralph DeMasi, Miklos Salgo, Nick Cammack
Publikováno v:
AIDS Research and Human Retroviruses. 22:375-385
Enfuvirtide (T-20) is the first entry inhibitor approved for treatment of HIV infection and acts by inhibiting conformational changes in the viral envelope protein gp41 that are necessary for fusion of the virus and host cell membranes. Here we prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d8b8cd716ccf5629c14fa3104db5cd
https://doi.org/10.1089/aid.2006.22.375
https://doi.org/10.1089/aid.2006.22.375
Publikováno v:
Journal of biomolecular screening. 11(6)
There has been increasing interest in the identification of novel HIV entry inhibitors. For the discovery of these entry inhibitors, robust surrogate anti-HIV assays are highly desired. The authors report a novel anti-HIV assay system using Moloney m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87c17aa87a1987e3cc2900f59a596d2
https://pubmed.ncbi.nlm.nih.gov/16844967
https://pubmed.ncbi.nlm.nih.gov/16844967
Autor:
Nick Cammack, Nancy M. King, Gabrielle Heilek-Snyder, Celia A. Schiffer, Ellen A. Nalivaika, Moses Prabu-Jeyabalan
Publikováno v:
Antimicrobial agents and chemotherapy. 50(4)
In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved “envelope” that appears to be important for substrate recognition and the selection of drug-resistant m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc818f18af2b64a59615f3160174b97
https://pubmed.ncbi.nlm.nih.gov/16569872
https://pubmed.ncbi.nlm.nih.gov/16569872
Publikováno v:
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 36(4)
Previous studies have established the importance of substitutions at amino acids 36-45 of HIV-1 gp41 in the development of viral resistance to the peptide fusion inhibitor enfuvirtide. However, the influence of other loci in the HIV-1 envelope is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec9d1d881b48f0a547b5976b65df1e8
https://pubmed.ncbi.nlm.nih.gov/16765082
https://pubmed.ncbi.nlm.nih.gov/16765082
Autor:
Gabrielle, Heilek-Snyder, Pamela, Bean
Publikováno v:
American clinical laboratory. 21(1)
Contemporary phenotypic assays such as the PhenoSense HIV assay are more straightforward to interpret than genotyping results because they do not require the expert interpretation of complex mutation patterns. The drug susceptibility data provides in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1f9ccf610e54c49b1bc6015d93e7f2a
https://pubmed.ncbi.nlm.nih.gov/11975451
https://pubmed.ncbi.nlm.nih.gov/11975451