Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gabrielle G.M. Pinkse"'
Autor:
Frans H. J. Claas, Timothy Tree, J H L Velthuis, Daniel Pipeleers, Gabrielle G.M. Pinkse, Dave L. Roelen, P M W van der Meer-Prins, Bart Keymeulen, Bart O. Roep, Pieter Gillard, Gaby Duinkerken, Volkert A L Huurman, Robert Hilbrands
Publikováno v:
American Journal of Transplantation. 9:382-388
Islet cell transplantation can cure type 1 diabetes, but allograft rejection and recurrent autoimmunity may contribute to decreasing insulin independence over time. In this study we report the association of allograft-specific proliferative and cytok
Publikováno v:
Annals of the New York Academy of Sciences. 1079:19-23
Islet autoreactive CD8 T cells are plausible candidates for direct beta cell toxicity in type 1 diabetes (T1DM). In 2005, cellular studies in the pathogenesis of this disease have reached a new milestone. Autoreactive CD8 T cells have been defined an
Autor:
Bart O. Roep, Chantal Mathieu, Bart Keymeulen, Volkert A L Huurman, Petronella M. W. van der Meer-Prins, Gabrielle G.M. Pinkse, Gaby Duinkerken, Behrooz Z. Alizadeh, Pieter Gillard, Pieter van de Linde, Minke F. J. Versteeg-van der Voort Maarschalk, Robert Hilbrands, Frans Gorus, Koen Verbeeck, Frans H. J. Claas, Dave L. Roelen, Daniel Pipeleers
Publikováno v:
PLoS ONE
PLoS ONE. PUBLIC LIBRARY SCIENCE
Vrije Universiteit Brussel
PLoS ONE, Vol 3, Iss 6, p e2435 (2008)
PLoS ONE. PUBLIC LIBRARY SCIENCE
Vrije Universiteit Brussel
PLoS ONE, Vol 3, Iss 6, p e2435 (2008)
BACKGROUND: Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin-independent in the following years. We tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8228b97ea9b1c9183a105f5ad1f01258
http://dx.plos.org/10.1371/journal.pone.0002435
http://dx.plos.org/10.1371/journal.pone.0002435
Autor:
Gabrielle G.M. Pinkse, Bart O. Roep, A. R. Van Der Slik, Wendy W. Unger, Ferry Ossendorp, Michel G.D. Kester, Jan W. Drijfhout, D.V. Serreze, S. MULDER-van der Kracht
Publikováno v:
Annals of the New York Academy of Sciences. 1103
Type 1 diabetes (T1D) is a multifactorial disease characterized by the infiltration and subsequent destruction of the pancreatic insulin-producing beta cells by autoreactive T cells. CD8(+) T cells play an essential role in this beta cell destruction
Autor:
Gabrielle G.M. Pinkse, Emile de Heer, Jan A. Bruijn, Onno T. Terpstra, Wendy P. Bouwman, Reshma Jiawan-Lalai
Publikováno v:
Diabetes. 55(2)
Islet transplantation is associated with a high rate of early graft failure caused by early immune attack and poor functionality of islets. Apoptosis of islet cells appears soon after islet isolation and primarily involves the β-cell. The purpose of
Autor:
Jan W. Drijfhout, Bart O. Roep, Ferry Ossendorp, Daniel Pipeleers, Gabrielle G.M. Pinkse, Michel G.D. Kester, Cees A. M. Bergen, Odette H. M. Tysma, Peter A. van Veelen, Bart Keymeulen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(51)
Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an important target of the autoimmune response associated with β cell destruction. The mechanism of destruction is still unknown. Here, we provide evidence for CD8 T cell autore
Publikováno v:
Journal of hepatology. 42(1)
Background/Aims Allogeneic cell transplantation is characterized by a lack of sustained survival of the transplanted cells in the recipient. Activation of the appropriate integrin-linked signaling pathways in cells can promote cell survival. The purp
Autor:
Jan A. Bruijn, O. T. Terpstra, E. de Heer, Gabrielle G.M. Pinkse, Mathieu H.M. Noteborn, E. Steenvoorde, S. Hogendoorn
Publikováno v:
Diabetologia. 47(1)
Large quantities of pure viable donor islets are necessary for clinical transplantation. At present, low yields and low viability of pancreatic islets after transplantation necessitate the use of multiple donors for a single recipient. In this study