Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gabrielle E. Rieckhof"'
Publikováno v:
PLoS Biology, Vol 5, Iss 11 (2007)
Externí odkaz:
https://doaj.org/article/e374f9b65fc04a09883f588f6fcc348b
Publikováno v:
PLoS Biology, Vol 5, Iss 10, p e251 (2007)
In both insects and mammals, spermatids eliminate their bulk cytoplasm as they undergo terminal differentiation. In Drosophila, this process of dramatic cellular remodeling requires apoptotic proteins, including caspases. To gain further insight into
Externí odkaz:
https://doaj.org/article/12660cef9251453e94123458251928b4
Autor:
Shereen Ezzat, Anil K. Rustgi, Stuart L. Schreiber, Kay Washington, Arul M. Chinnaiyan, Andrew L. Kung, Elena V. Komissarova, Charles Karan, Beatrice S. Knudsen, Diane Reidy-Lagunes, Daniel Diolaiti, Zhong Li, Irvin M. Modlin, Roberto Bergamaschi, Andrea Frilling, Jakob Regberg, David C. Metz, Filemon S. Dela Cruz, Deepti Dhall, Douglas A. Fraker, Emer Leahy, Ülo Langel, Ronald Realubit, Laura H. Tang, Stefano Serra, Afshin Ghavami, Prem S. Subramaniam, Antonia R. Sepulveda, Tony Detre, Lisa Bodei, Jeffrey W. Milsom, Xiaopu Yuan, Mark Kidd, Andrea Califano, Daniel Kaemmerer, Kyoung Mi Kim, Young Suk Park, Mariano J. Alvarez, Paul A. Clemons, Elizabeth A. Hagan, Robert E. Roses, Helen Remotti, Jeeyun Lee, Hai Li, Roswitha Pfragner, Massimo Barberis, Merten Hommann, Virginia A. LiVolsi, Allison R. Rainey, Michelle K. Kim, Adina Grunn, Gabrielle E. Rieckhof, Chanjuan Shi, Bertram Wiedenmann, Hee C. Kim, Dirk Jaeger, Lakshmi P. Kunju, Mahalaxmi Aburi
Publikováno v:
Nat Genet
We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual patients. Compounds are prioritized on the basis of their ability to invert the concerted a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d09dc99068d6a36407f03e9aa66176
http://hdl.handle.net/10044/1/60492
http://hdl.handle.net/10044/1/60492
Autor:
Archana Iyer, Harshil Dhruv, Kenneth Aldape, Andrea Califano, Michael E. Berens, Gabrielle E. Rieckhof, J.C. Chen, Flaminia Talos, Michael M. Shen, Mariano J. Alvarez, Kristin Diefes
Publikováno v:
Cell. 159(2):402-414
SummaryIdentification of driver mutations in human diseases is often limited by cohort size and availability of appropriate statistical models. We propose a framework for the systematic discovery of genetic alterations that are causal determinants of
Publikováno v:
WIREs Systems Biology and Medicine. 4:311-325
The explosion of genomic, transcriptomic, proteomic, metabolomic, and other omics data is challenging the research community to develop rational models for their organization and interpretation to generate novel biological knowledge. The development
Publikováno v:
Journal of Biological Chemistry. 278:41099-41108
Voltage-gated calcium channels couple changes in membrane potential to neuronal functions regulated by calcium, including neurotransmitter release. Here we report that presynaptic N-type calcium channels not only control neurotransmitter release but
Autor:
David A. Wah, Robert T. Sauer, Tania A. Baker, Gabrielle E. Rieckhof, Daniel N. Bolon, Igor Levchenko
Publikováno v:
Molecular Cell. 12:355-363
SspB dimers bind proteins bearing the ssrA-degradation tag and stimulate their degradation by the ClpXP protease. Here, E. coli SspB is shown to contain a dimeric substrate binding domain of 110-120 N-terminal residues, which binds ssrA-tagged substr
Autor:
Celine Lefebvre, Gabrielle E. Rieckhof, Stacey J. Adam, Brygida Bisikirska, Kai Wang, Andrea Califano, Mariano J. Alvarez, Presha Rajbhandari, Rachel L. Cox, Dean W. Felsher
Publikováno v:
Oncogene. 32(45)
The MYC proto-oncogene is associated with the pathogenesis of most human neoplasia. Conversely, its experimental inactivation elicits oncogene addiction. While MYC constitutes a formidable therapeutic target, it also plays an essential role in normal
Publikováno v:
The EMBO Journal. 12:3587-3598
The structure of a ribonucleoprotein complex formed at the 5'-end of poliovirus RNA was investigated. This complex involves the first 90 nucleotides of poliovirus genome which fold into a cloverleaf-like structure and interact with both uncleaved 3CD
Autor:
David A. Wah, Douglas V. Laurents, Anish Das, Nalini Kanneganti, B. Syed Ibrahim, Jennifer B. Palenchar, Gabrielle E. Rieckhof, Vivian Bellofatto
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
6 pags, 4 figs
In trypanosomes, the production of mRNA relies on the synthesis of the spliced leader (SL) RNA. Expression of the SL RNA is initiated at the only known RNA polymerase II promoter in these parasites. In the pathogenic trypanosome,
In trypanosomes, the production of mRNA relies on the synthesis of the spliced leader (SL) RNA. Expression of the SL RNA is initiated at the only known RNA polymerase II promoter in these parasites. In the pathogenic trypanosome,