Caffeine and Cisplatin Effectively Targets the Metabolism of a Triple-Negative Breast Cancer Cell Line Assessed via Phasor-FLIM

Autor: Stephanie M. Pascua, Gabrielle E. McGahey, Ning Ma, Justin J. Wang, Michelle A. Digman

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 7, p 2443 (2020)

Triple-negative tumor cells, a malignant subtype of breast cancer, lack a biologically targeted therapy. Given its DNA repair inhibiting properties, caffeine has been shown to enhance the effectiveness of specific tumor chemotherapies. In this work,

Externí odkaz: https://doaj.org/article/60554b6a8aa14a54997dcc4e9a2db207

Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility

Autor: Austin E. Y. T. Lefebvre, Michelle A. Digman, Emma J. Mah, Gabrielle E. McGahey, Albert F. Yee

Publikováno v: Mah, Emma J; Lefebvre, Austin EYT; McGahey, Gabrielle E; Yee, Albert F; & Digman, Michelle A. (2018). Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility.. Scientific reports, 8(1), 17094. doi: 10.1038/s41598-018-35381-9. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/9sb7g6bf
Scientific Reports
Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Extracellular matrix (ECM) mechanical properties upregulate cancer invasion, cell contractility, and focal adhesion formation. Alteration in energy metabolism is a known characteristic of cancer cells (i.e., Warburg effect) and modulates cell invasio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ec8fe0ab824f706cdaf46536a1d9bc
http://www.escholarship.org/uc/item/9sb7g6bf