Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gabrielle E. Foxa"'
Autor:
Cassandra R. Diegel, Ina Kramer, Charles Moes, Gabrielle E. Foxa, Mitchell J. McDonald, Zachary B. Madaj, Sabine Guth, Jun Liu, Jennifer L. Harris, Michaela Kneissel, Bart O. Williams
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Proper regulation of Wnt signaling is critical for normal bone development and homeostasis. Mutations in several Wnt signaling components, which increase the activity of the pathway in the skeleton, cause high bone mass in human subjects and
Externí odkaz:
https://doaj.org/article/61eebd1859c547e987869a53f524eaf5
Autor:
Ryan C. Riddle, Bart O. Williams, Gabrielle E. Foxa, Megan N. Michalski, Priyanka Kushwaha, Ryan E. Tomlinson, Soohyun P. Kim
Publikováno v:
J Cell Physiol
The activation of the Wnt/β-catenin signaling pathway is critical for skeletal development but surprisingly little is known about the requirements for the specific frizzled (Fzd) receptors that recognize Wnt ligands. To define the contributions of i
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071609880
Methods in Molecular Biology ISBN: 9781071609880
Our laboratories have used genetically engineered mouse models (GEMMs) to assess genetic contributions to skeletal diseases such as osteoporosis and osteoarthritis. Studies on the genetic contributions to OA are often done by assessing how GEMMs resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1655c1a0391c9142828a0dec4c29d98
https://europepmc.org/articles/PMC7934896/
https://europepmc.org/articles/PMC7934896/
Autor:
Cassandra R. Diegel, Gabrielle E. Foxa, Bart O. Williams, Jonathan N. Lensing, Zachary Madaj, Nicole J. Ethen, John L. Ubels
Publikováno v:
The CRISPR journal. 3(4)
Humans carrying homozygous loss-of-function mutations in the Wnt co-receptor, low-density lipoprotein receptor-related protein 5 (LRP5), develop osteoporosis and a defective retinal vasculature known as familial exudative vitreoretinopathy (FEVR) due
Autor:
Cassandra R, Diegel, Steven, Hann, Ugur M, Ayturk, Jennifer C W, Hu, Kyung-Eun, Lim, Casey J, Droscha, Zachary B, Madaj, Gabrielle E, Foxa, Isaac, Izaguirre, Alexander G, Robling, Matthew L, Warman, Bart O, Williams
Publikováno v:
PLoS Genetics
Autor:
Katie M. Sorensen, Min H. Kang, Bart O. Williams, Lyong Heo, Patrick J. Grohar, Timothy J. Triche, Jessica E Rosien, C. Patrick Reynolds, Maggie H. Chasse, Zachary Madaj, Gabrielle E. Foxa, Benjamin K. Johnson, Ian Beddows, Elissa Boguslawski, Susan M. Kitchen-Goosen
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 2, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 2, Pp n/a-n/a (2021)
Rhabdoid tumor (RT) is a pediatric cancer characterized by the inactivation of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. Although this deletion is the known oncogenic driver, there are limited effective therapeutic options for t
Autor:
Jonathan N. Lensing, Vari Vivarium, Nicole J. Ethen, Gabrielle E. Foxa, Cassandra R. Diegel, Bart O. Williams, John L. Ubels, Zachary Madaj, Transgenics Core
Human patients carrying homozygous loss-of-function mutations in the low-density lipoprotein receptor related protein 5 (LRP5) develop osteoporosis pseudoglioma (OPPG), a syndrome characterized by early-onset low bone mass and vision problems caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945c668411c1f3351978a84db591adee
Autor:
Jianshuang Li, Di Lu, Jie Li, Bart O. Williams, Kevin Weaver, Gabrielle E. Foxa, Tao Yang, Huadie Liu
Publikováno v:
Journal of Bone and Mineral Research. 33:1773-1784
Single-nucleotide polymorphisms in the LRP1 gene coding sequence are associated with low bone mass, and cell culture studies suggest that LRP1 plays a role in osteoblast proliferation and osteoblast-mediated osteoclastogenesis. However, the in vivo f
Autor:
Mitchell J. McDonald, Babita Madan, Gabrielle E. Foxa, David M. Virshup, Cassandra R. Diegel, Bart O. Williams
Publikováno v:
Bone Research, Vol 6, Iss 1, Pp 1-10 (2018)
Bone Research
Bone Research
Dysregulated Wnt signaling is associated with the pathogenesis of cancers, fibrosis, and vascular diseases. Inhibition of Wnt signaling has shown efficacy in various pre-clinical models of these disorders. One of the key challenges in developing targ
Autor:
Gabrielle E. Foxa, Alexander G. Robling, Bart O. Williams, Matthew L. Warman, Noorulain Paracha, Bohdan Pidhaynyy, Cassandra R. Diegel, Zachary Madaj, Transgenics Core, Isaac Izaguirre, Steven Hann, Ugur M. Ayturk, Vari Vivarium, Jennifer C. W. Hu, Casey J. Droscha, Terry L. Dowd, Kyung-Eun Lim
Osteocalcin (OCN), the most abundant non-collagenous protein in the bone matrix, is reported to be a bone-derived endocrine hormone with wide-ranging effects on many aspects of physiology, including glucose metabolism and male fertility. Many of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0a037270e2989e642ae9471cd14aa6
https://doi.org/10.1101/732800
https://doi.org/10.1101/732800