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of 4
pro vyhledávání: '"Gabrielle Almer"'
Autor:
Ali Naini, Arthur P. Hays, Gorazd Rosoklija, Christelle Guégan, Gabrielle Almer, Caiping Chen, Peter Teismann, Serge Przedborski
Publikováno v:
Annals of Neurology. 49:176-185
Mutations in the copper/zinc superoxide dismutase (mSOD1) gene are associated with a familial form of amyotrophic lateral sclerosis (ALS), and their expression in transgenic mice produces an ALS-like syndrome. Recent observations suggest a role for i
Autor:
Peter Teismann, Vladimir S. Kostic, J. Halaschek-Wiener, Z. Stevic, L. Deecke, Gabrielle Almer, Serge Przedborski
Publikováno v:
Neurology. 58:1277-1279
Levels of the potent pro-inflammatory prostaglandin E2 (PGE2) are elevated in postmortem spinal cords from patients with ALS, and inhibition of a key PGE2-synthesizing enzyme, cylcooxygenase-2, is neuroprotective in an in vitro model of ALS. The auth
Autor:
Serge, Przedborski, Vernice, Jackson-Lewis, Ruth, Djaldetti, Gabriel, Liberatore, Miquel, Vila, Slobodanka, Vukosavic, Gabrielle, Almer
Publikováno v:
Restorative neurology and neuroscience. 16(2)
MPTP causes damage to substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons as seen in Parkinson's disease (PD). After sys-temic administration of MPTP, its active metabolite, MPP +, accumulates within SNpc DA neurons, where it inhibits ATP
Autor:
Gabrielle Almer, Krystl Frank, Serge Przedborski, Margaret Dykes-Hoberg, Jeffrey D. Rothstein, Peter Teismann, Daniel B. Drachman
Publikováno v:
Annals of neurology. 52(6)
The pathogenesis of cell death in amyotrophic lateral sclerosis (ALS) may involve glutamate-mediated excitotoxicity, oxidative damage, and apoptosis. We used a transgenic mouse model of ALS to determine the effect of inhibition of cyclooxygenase-2 in