Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Gabrielle A. Lockett"'
Autor:
Todd M. Everson, Hongmei Zhang, Gabrielle A. Lockett, Akhilesh Kaushal, Melinda Forthofer, Susan L. Ewart, Kimberley Burrows, Caroline L. Relton, Gemma C. Sharp, A. John Henderson, Veeresh K. Patil, Faisal I. Rezwan, S. Hasan Arshad, John W. Holloway, Wilfried Karmaus
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 15, Iss 1, Pp 1-12 (2019)
Abstract Background To identify novel epigenetic markers of adolescent asthma and replicate findings in an independent cohort, then explore whether such markers are detectable at birth, predictive of early-life wheeze, and associated with gene expres
Externí odkaz:
https://doaj.org/article/cb8fd19935404f6c9593db29191ef4bb
Autor:
David O. Bates, Vincent Pang, Judith M. Vonk, Charlote K. Billington, John W. Holloway, Sangita Bhaker, Cornelis J. Vermeulen, Don D. Sin, Ian Sayers, Martin D. Tobin, Peter H. Howarth, F. Nicole Dijk, David C. Nickle, Ian P. Hall, Yohan Bossé, Louise V. Wain, Dominick E. Shaw, John D Blakey, Andrew M. Fogarty, Amisha Singapuri, Michael A. Portelli, Martijn C. Nawijn, Cheng J. Xu, Andrew V. Benest, Ma'en Obeidat, Liam G Heaney, Jenny Hankinson, Maarten van den Berge, Rekha Chaudhuri, Angela Simpson, Tricia M. McKeever, Simon R. Johnson, Adel H. Mansur, Robert Niven, Zara Pogson, Gabrielle A. Lockett, Christopher E. Brightling, Amanda P. Henry, Neil C. Thomson, Nick Shrine, Gerard H. Koppelman, Maria Ketelaar, Alen Faiz
Publikováno v:
Journal of Allergy and Clinical Immunology, 147(1), 144-157. MOSBY-ELSEVIER
Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevated in sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2e19b5c3a77f7d0087040f985a7c81
https://doi.org/10.1016/j.jaci.2020.04.051
https://doi.org/10.1016/j.jaci.2020.04.051
Autor:
John W. Holloway, Hongmei Zhang, Caroline L Relton, A. John Henderson, Gabrielle A. Lockett, Susan Ewart, Kimberley Burrows, Melinda Forthofer, Akhilesh Kaushal, S. Hasan Arshad, Wilfried Karmaus, Veeresh Patil, Gemma C Sharp, Faisal I. Rezwan, Todd M. Everson
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 15, Iss 1, Pp 1-12 (2019)
Everson, T M, Zhang, H, Lockett, G A, Kaushal, A, Forthofer, M, Ewart, S, Burrows, K, Relton, C, Sharp, G, Henderson, J, Patil, V, Rezwan, F I, Arshad, H, Holloway, J W & Karmaus, W 2019, ' Epigenome-wide association study of asthma-and wheeze characterizes loci within HK1 ', Allergy, Asthma and Clinical Immunology, vol. 15, 43 (2019) . https://doi.org/10.1186/s13223-019-0356-z
Everson, T M, Zhang, H, Lockett, G A, Kaushal, A, Forthofer, M, Ewart, S, Burrows, K, Relton, C, Sharp, G, Henderson, J, Patil, V, Rezwan, F I, Arshad, H, Holloway, J W & Karmaus, W 2019, ' Epigenome-wide association study of asthma-and wheeze characterizes loci within HK1 ', Allergy, Asthma and Clinical Immunology, vol. 15, 43 (2019) . https://doi.org/10.1186/s13223-019-0356-z
Background: To identify novel epigenetic markers of adolescent asthma and replicate findings in an independent cohort, then explore whether such markers are detectable at birth, predictive of early-life wheeze, and associated with gene expression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d2608b25255ef844f7640ee758580a
http://link.springer.com/article/10.1186/s13223-019-0356-z
http://link.springer.com/article/10.1186/s13223-019-0356-z
Autor:
Charlotte K. Billington, Gerard H. Koppelman, Liam G Heaney, Adel H. Mansur, Jenny Hankinson, Martijn C. Nawijn, Corry-Anke Brandsma, Sangita Bhaker, Andrew M. Fogarty, Dominick E. Shaw, Michael A. Portelli, Cornelis J. Vermeulen, Judith M. Vonk, Nick Shrine, Amanda P. Henry, Ian Sayers, Yohan Bossé, Maria Ketelaar, Martin D. Tobin, Peter H. Howarth, David C. Nickle, Néomi S. Grotenboer, Ma'en Obeidat, Gabrielle A. Lockett, John W. Holloway, Christopher E. Brightling, Alen Faiz, Rekha Chaudhuri, Tricia M. McKeever, Simon R. Johnson, Paul de Vos, Dirkje S. Postma, Zara Pogson, Neil C. Thomson, Sharon Brouwer, Maarten van den Berge, Angela Simpson, Amisha Singapuri, Robert Niven, F. Nicole Dijk, Ian P. Hall, Louise V. Wain, John D Blakey
Publikováno v:
Portelli, M A, Dijk, F N, Ketelaar, M E, Shrine, N, Hankinson, J, Bhaker, S, Grotenboer, N S, Obeidat, M, Henry, A P, Billington, C K, Shaw, D, Johnson, S R, Pogson, Z E, Fogarty, A, McKeever, T M, Nickle, D C, Bossé, Y, van den Berge, M, Faiz, A, Brouwer, S, Vonk, J M, de Vos, P, Brandsma, C-A, Vermeulen, C J, Singapuri, A, Heaney, L G, Mansur, A H, Chaudhuri, R, Thomson, N C, Holloway, J W, Lockett, G A, Howarth, P H, Niven, R, Simpson, A, Blakey, J D, Tobin, M D, Postma, D S, Hall, I P, Wain, L V, Nawijn, M C, Brightling, C E, Koppelman, G H & Sayers, I 2020, ' Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium ', JCI insight, vol. 5, no. 8, pp. 1-19 . https://doi.org/10.1172/jci.insight.132446
JCI Insight
JCI Insight, 5(8):132446. AMER SOC CLINICAL INVESTIGATION INC
JCI Insight
JCI Insight, 5(8):132446. AMER SOC CLINICAL INVESTIGATION INC
The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35eec0d3bd47361ef723e102569f7099
https://doi.org/10.1172/jci.insight.132446
https://doi.org/10.1172/jci.insight.132446
Autor:
Frances Mitchell, Wilfried Karmaus, Ramesh Kurukulaaratchy, Vimala Devi Janjanam, Nandini Mukherjee, Gabrielle A. Lockett, Hongmei Zhang, Hasan Arshad, Faisal I. Rezwan, John W. Holloway
Publikováno v:
Vaccine. 34:6493-6501
BackgroundVaccinations have been suggested to be associated with increased risk of allergic diseases. Tetanus vaccination is one of the most frequently administered vaccines as a part of wound management and was also found to be associated with incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5ff0dd00cdf7d1d87a4d6e0023d1ad
https://doi.org/10.1016/j.vaccine.2016.10.068
https://doi.org/10.1016/j.vaccine.2016.10.068
Autor:
Peter H. Howarth, Clair Barber, Margarida Castro, Elliott Scott, Anoop Chauhan, Tom Brown, John W. Holloway, Laurie Lau, Gabrielle A. Lockett
Publikováno v:
Airway cell biology and immunopathology.
Background: The aim of this study was to evaluate the role of serum and sputum YKL-40 measurements as biomarkers in severe asthma phenotypes. Material and Methods: 243 adult subjects (48.9±14.2 years) from the Wessex Severe Asthma Cohort (WSAC), spi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b59025e35c16844f6cb0c5b2c6b49d9
https://doi.org/10.1183/13993003.congress-2019.pa4084
https://doi.org/10.1183/13993003.congress-2019.pa4084
Autor:
Susan Ewart, Ali H. Ziyab, Wilfried Karmaus, Nandini Mukherjee, John W. Holloway, Victoria Bion, Nelís Soto-Ramírez, Ramesh Kurukulaaratchy, Hongmei Zhang, William B. Sherwood, Faisal I. Rezwan, S. Hasan Arshad, Gabrielle A. Lockett
Publikováno v:
Clinical Epigenetics
Background Breastfeeding is protective against many long-term diseases, yet the mechanisms involved are unknown. Leptin gene (LEP) is reported to be associated with body mass index (BMI). On the other hand, breastfeeding duration has been found to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0098c851685c171cfa39e6753d8ca611
http://europepmc.org/articles/PMC6716837
http://europepmc.org/articles/PMC6716837
Autor:
Pierre Antoine Dugué, Wilfried Karmaus, Hongmei Zhang, Roger L. Milne, Y. M. Geurts, Gabrielle A. Lockett, John W. Holloway
Publikováno v:
Allergy. 71:1501-1504
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7496ff5c59df43466f6f077c47db0cb6
https://doi.org/10.1111/all.12949
https://doi.org/10.1111/all.12949
Autor:
Syed Hasan Arshad, Victoria Bion, Wilfried Karmaus, Hongmei Zhang, Nelís Soto-Ramírez, Carina Venter, John W. Holloway, Gabrielle A. Lockett
Publikováno v:
Allergy. 71:661-670
Background: WHO guidelines advocate breastfeeding for six months, and EAACI recommends exclusive breastfeeding for 4-6 months. However, evidence for breastfeeding to prevent asthma and allergic disease is conflicting. We examined whether following re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56efab90100a535fccd8e9875cd9d50
https://doi.org/10.1111/all.12833
https://doi.org/10.1111/all.12833
Autor:
Todd M, Everson, Hongmei, Zhang, Gabrielle A, Lockett, Akhilesh, Kaushal, Melinda, Forthofer, Susan L, Ewart, Kimberley, Burrows, Caroline L, Relton, Gemma C, Sharp, A John, Henderson, Veeresh K, Patil, Faisal I, Rezwan, S Hasan, Arshad, John W, Holloway, Wilfried, Karmaus
Publikováno v:
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Background To identify novel epigenetic markers of adolescent asthma and replicate findings in an independent cohort, then explore whether such markers are detectable at birth, predictive of early-life wheeze, and associated with gene expression in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba7a40439d2ddf0cf518d645fa045e87
https://pubmed.ncbi.nlm.nih.gov/31367216
https://pubmed.ncbi.nlm.nih.gov/31367216