Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gabrielle, Stack"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Salmonella Typhi produces the typhoid toxin. Here, Fowler et al. show that S. Typhi produces two forms of typhoid toxin that are differentially regulated and display different trafficking properties and different effects when administered to laborato
Externí odkaz:
https://doaj.org/article/4ef4c66184da419daeb906136af36518
Publikováno v:
Viruses, Vol 4, Iss 8, Pp 1182-1201 (2012)
Herpesviruses employ a plethora of mechanisms to circumvent clearance by host immune responses. A key feature of mammalian immune systems is the employment of regulatory pathways that limit immune responsiveness. The primary functions of these mechan
Externí odkaz:
https://doaj.org/article/9250afc8674c4b3e806d4e393df66a15
Autor:
Gabrielle Stack, Emma Jones, Morgan Marsden, Maria A Stacey, Robert J Snelgrove, Paul Lacaze, Laura C Jacques, Simone M Cuff, Richard J Stanton, Awen M Gallimore, Tracy Hussell, Gavin W G Wilkinson, Peter Ghazal, Philip R Taylor, Ian R Humphreys
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004641 (2015)
CD200 receptor (CD200R) negatively regulates peripheral and mucosal innate immune responses. Viruses, including herpesviruses, have acquired functional CD200 orthologs, implying that viral exploitation of this pathway is evolutionary advantageous. Ho
Externí odkaz:
https://doaj.org/article/e69f5ed2db144e32af2dee37e2b1a0ca
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
Bacterial toxins with an AB5 architecture consist of an active (A) subunit inserted into a ring-like platform comprised of five delivery (B) subunits. Salmonella Typhi, the cause of typhoid fever, produces an unusual A2B5 toxin known as typhoid toxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275f47ccbe36970468444a3dbf00bfdb
https://doaj.org/article/4ef4c66184da419daeb906136af36518
https://doaj.org/article/4ef4c66184da419daeb906136af36518
Autor:
Sarah E. Smith, Qi Liang, Jorge E. Galán, Xuyao Jiao, Allan Bradley, Paul Kellam, Gabrielle Stack
Publikováno v:
Infect Immun
Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5 architecture with two active subunits, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f673a8f8e5db6bad0dbb994c58f5d635
https://doi.org/10.1128/iai.00292-20
https://doi.org/10.1128/iai.00292-20
Autor:
Ushma Galal, Jorge E. Galán, Gabrielle Stack, Danielle Campbell, Gordon Dougan, Christopher A Darlow, Jennifer Hill, Amber J Barton, Celina Jin, L Blackwell, Elizabeth Jones, Xuyao Jiao, Charlotte Black, Brian Angus, Yael Rosenberg-Hasson, Christoph J. Blohmke, Maria Lara-Tejero, Claire Jones, Helena Thomaides-Brears, Gerlinde Obermoser, Andrew J. Pollard, Malick M. Gibani, Eva Heinz, L Silva-Reyes, Christina Dold, Juliette Meek, Susana Camara
Publikováno v:
NATURE MEDICINE
Nature Medicine
Nature Medicine
Salmonella Typhi is a human host-restricted pathogen that is responsible for typhoid fever in approximately 10.9 million people annually1. The typhoid toxin is postulated to have a central role in disease pathogenesis, the establishment of chronic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0c20c3be6c590f65b1f66c549bdec1
http://hdl.handle.net/10044/1/70729
http://hdl.handle.net/10044/1/70729
Autor:
Hai Yu, Lingquan Deng, Xi Chen, Gabrielle Stack, Ajit Varki, Xiang Gao, Yuko Naito-Matsui, Jorge E. Galán
Publikováno v:
Nature microbiology, vol 2, iss 12
Nature microbiology
Nature microbiology
The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b6d869da263ae655622951fe4a8494
https://escholarship.org/uc/item/3xx5t709
https://escholarship.org/uc/item/3xx5t709
Autor:
Maria A, Stacey, Simon, Clare, Mathew, Clement, Morgan, Marsden, Juneid, Abdul-Karim, Leanne, Kane, Katherine, Harcourt, Cordelia, Brandt, Ceri A, Fielding, Sarah E, Smith, Rachael S, Wash, Silvia Gimeno, Brias, Gabrielle, Stack, George, Notley, Emma L, Cambridge, Christopher, Isherwood, Anneliese O, Speak, Zoë, Johnson, Walter, Ferlin, Simon A, Jones, Paul, Kellam, Ian R, Humphreys
Publikováno v:
The Journal of Clinical Investigation
The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans. Here, we used the murine CMV (MCMV) mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b5d0f260eb058d4a4aee340511cab30
http://hdl.handle.net/10044/1/69587
http://hdl.handle.net/10044/1/69587
Publikováno v:
Current opinion in microbiology. 35
Typhoid toxin is a unique A2B5 exotoxin and an important virulence factor for Salmonella Typhi, the cause of typhoid fever. In the decade since its initial discovery, great strides have been made in deciphering the unusual biological program of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1d6e9e1d6369b7af036955c70b2730
https://pubmed.ncbi.nlm.nih.gov/28213043
https://pubmed.ncbi.nlm.nih.gov/28213043
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology
Frontiers in Immunology
Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0955f244de726cdb1b37ed518590881d
http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00211/full
http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00211/full