Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gabriella Widmer"'
Autor:
Haitao Liu, Sayan Ghosh, Tanuja Vaidya, Sridhar Bammidi, Chao Huang, Peng Shang, Archana Padmanabhan Nair, Olivia Chowdhury, Nadezda A. Stepicheva, Anastasia Strizhakova, Stacey Hose, Nikolaos Mitrousis, Santosh Gopikrishna Gadde, Thirumalesh MB, Pamela Strassburger, Gabriella Widmer, Eleonora M. Lad, Patrice E. Fort, José-Alain Sahel, J. Samuel Zigler Jr., Swaminathan Sethu, Peter D. Westenskow, Alan D. Proia, Akrit Sodhi, Arkasubhra Ghosh, Derrick Feenstra, Debasish Sinha
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression of stimulator of interferon genes (STING) is increased in patients with DR
Externí odkaz:
https://doaj.org/article/b18fbfa1ae7541e5a0a6f27bd00d5aed
Autor:
Jörg T Regula, Peter Lundh von Leithner, Richard Foxton, Veluchamy A Barathi, Chui Ming Gemmy Cheung, Sai Bo Bo Tun, Yeo Sia Wey, Daiju Iwata, Miroslav Dostalek, Jörg Moelleken, Kay G Stubenrauch, Everson Nogoceke, Gabriella Widmer, Pamela Strassburger, Michael J Koss, Christian Klein, David T Shima, Guido Hartmann
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 985-985 (2017)
Externí odkaz:
https://doaj.org/article/7b40d5bc3c9247c09518efa7de23d0dc
Autor:
Thais Gazzi, Benjamin Brennecke, Kenneth Atz, Claudia Korn, David Sykes, Gabriel Forn-Cuni, Patrick Pfaff, Roman C. Sarott, Matthias V. Westphal, Yelena Mostinski, Leonard Mach, Malgorzata Wasinska-Kalwa, Marie Weise, Bradley L. Hoare, Tamara Miljuš, Maira Mexi, Nicolas Roth, Eline J. Koers, Wolfgang Guba, André Alker, Arne C. Rufer, Eric A. Kusznir, Sylwia Huber, Catarina Raposo, Elisabeth A. Zirwes, Anja Osterwald, Anto Pavlovic, Svenja Moes, Jennifer Beck, Matthias Nettekoven, Irene Benito-Cuesta, Teresa Grande, Faye Drawnel, Gabriella Widmer, Daniela Holzer, Tom van der Wel, Harpreet Mandhair, Michael Honer, Jürgen Fingerle, Jörg Scheffel, Johannes Broichhagen, Klaus Gawrisch, Julián Romero, Cecilia J. Hillard, Zoltan V. Varga, Mario van der Stelt, Pal Pacher, Jürg Gertsch, Christoph Ullmer, Peter J. McCormick, Sergio Oddi, Herman P. Spaink, Mauro Maccarrone, Dmitry B. Veprintsev, Erick M. Carreira, Uwe Grether, Marc Nazaré
Publikováno v:
Gazzi, Thais; Brennecke, Benjamin; Atz, Kenneth; Korn, Claudia; Sykes, David; Forn-Cuni, Gabriel; Pfaff, Patrick; Sarott, Roman C; Westphal, Matthias V; Mostinski, Yelena; Mach, Leonard; Wasinska-Kalwa, Malgorzata; Weise, Marie; Hoare, Bradley L; Miljuš, Tamara; Mexi, Maira; Roth, Nicolas; Koers, Eline J; Guba, Wolfgang; Alker, André; ... (2022). Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe. Chemical Science, 13(19), pp. 5539-5545. The Royal Society of Chemistry 10.1039/d1sc06659e
Chemical Science, 13(19), 5539-5545
Chemical Science
Chemical Science, 13(19), 5539-5545
Chemical Science
Despite its essential role in the (patho)physiology of several diseases, CB2R tissue expression profiles and signaling mechanisms are not yet fully understood. We report the development of a highly potent, fluorescent CB2R agonist probe employing str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e61ac61b6e5b29da1ceeb545f2c056
http://hdl.handle.net/11697/192023
http://hdl.handle.net/11697/192023
Autor:
Sascha Fauser, Tina Schick, Gabriella Widmer, Ashwath Jayagopal, G. Duchateau-Nguyen, Lebriz Altay, Paolo Piraino, Vasilena Sitnilska, Faye M. Drawnel
Publikováno v:
Eye (Lond)
OBJECTIVE: To investigate complement activation in aqueous humour of patients with early, intermediate and neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: Aqueous humour of 79 AMD patients (early, intermediate and neovascula
Autor:
Natasha L. Grimsey, Dmitry B. Veprintsev, Roman C. Sarott, Teresa Grande, Patrick Pfaff, Jürg Gertsch, Pal Pacher, Erick M. Carreira, Christoph Ullmer, Hermon Asmelash, Pattarin Hompluem, Svenja Moes, Daniela Holzer, Catarina Raposo, William R. Drobyski, Sylwia Huber, Jennifer Beck, Uwe Grether, Marc Nazaré, Claudia Korn, Zoltán Varga, Eline J. Koers, Jacopo Piovesan, Irene Benito-Cuesta, Klaus Gawrisch, Matthias Westphal, Benjamin Brennecke, Gabriella Widmer, Yurii Saroz, Eric Kusznir, Tom van der Wel, Anto Pavlovic, Kenneth Atz, Man C Vong, Tamara Miljuš, Peter J. McCormick, Mauro Maccarrone, Harpreet Mandhair, Samuel Ruiz de Martín Esteban, Sergio Oddi, Yelena Mostinski, Julián Romero, Elisabeth A. Zirwes, Anja Osterwald, Jürgen Fingerle, Cecilia J. Hillard, David A. Sykes, Alexei Yeliseev, Faye M. Drawnel, Mario van der Stelt, Marie Weise, Arne C. Rufer, Cheng-Yin Yuan, Thais Gazzi, Nicolas J. Roth, Michael Honer, Wolfgang Guba
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, 142(40), 16953-16964
Journal of the American Chemical Society, 142(40), 16953-16964
Pharmacological modulation of cannabinoid type 2 receptor (CB2R) holds promise for the treatment of numerous conditions, including inflammatory diseases, autoimmune disorders, pain, and cancer. Despite the significance of this receptor, researchers l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1774cb215365081fabff5fd4b151b22f
http://hdl.handle.net/11697/158602
http://hdl.handle.net/11697/158602
Autor:
Faye M. Drawnel, Jürgen Fingerle, Cecilia J. Hillard, David A. Sykes, Erick M. Carreira, Yurii Saroz, Christoph Ullmer, Natasha L. Grimsey, Daniela Holzer, Maira Mexi, Anja Osterwald, Dmitry B. Veprintsev, Patrick Pfaff, André Anker, Irene Benito-Cuesta, Matthias Westphal, Klaus Gawrisch, Benjamin Brennecke, Marie Weise, Julián Romero, Jennifer Beck, Anto Pavlovic, Gabriella Widmer, Kenneth Atz, Peter J. McCormick, Harpreet Mandhair, Michael Honer, Uwe Grether, Wolfgang Guba, Pal Pacher, Svenja Moes, Sylwia Huber, Bradley L. Hoare, Arne C. Rufer, Yelena Mostinski, Mario van der Stelt, Jürg Gertsch, Mauro Maccarrone, Claudia Korn, Roman C. Sarott, Elisabeth A. Zirwes, Catarina Raposo, Zoltán Varga, Tamara Miljuš, Thais Gazzi, Tom van der Wel, Teresa Grande, Eric Kusznir, Sergio Oddi, Marc Nazaré
Cannabinoid type 2 receptor (CB2R) is a fundamental part of the endocannabinoid signaling system (eCB system), and is known to play an important role in tissue injury, inflammation, cancer and pain. In stark contrast to its significance, the underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3cac06b852c3e7933e52745f95a639
https://doi.org/10.26434/chemrxiv.10283027.v1
https://doi.org/10.26434/chemrxiv.10283027.v1
Autor:
Faye M. Drawnel, Mauro Maccarrone, Catarina Raposo, Peter J. McCormick, Jürgen Fingerle, Cecilia J. Hillard, Svenja Moes, Marc Nazaré, Sergio Oddi, Natasha L. Grimsey, David A. Sykes, Marie Weise, Sylwia Huber, Matthias Westphal, Yurii Saroz, William R. Drobyski, Anto Pavlovic, Gabriella Widmer, Patrick Pfaff, Dmitry B. Veprintsev, Benjamin Brennecke, Kenneth Atz, Anja Osterwald, Erick M. Carreira, Grether U, Julián Romero, Yelena Mostinski, Yuan C, Christoph Ullmer, Hermon Asmelash, Pattarin Hompluem, Gazzi, Thais, Tamara Miljuš, Daniela Holzer, Alexei Yeliseev, Roman C. Sarott, Stelt Mvd, Wel Tvd, Arne C. Rufer, Harpreet Mandhair, Claudia Korn, Elisabeth A. Zirwes, Zoltán Varga, Irene Benito-Cuesta, Jennifer Beck, Klaus Gawrisch, Teresa Grande, Nicolas J. Roth, Michael Honer, Wolfgang Guba, Vong M, Jürg Gertsch, Pal Pacher
Pharmacological modulation of cannabinoid type 2 receptor (CB2R) holds promise for the treatment of numerous conditions including inflammatory diseases, autoimmune disorders, pain, and cancer. Despite its significance, researchers lack reliable tools
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2488c25f21762f3f55fbde432fa91266
https://doi.org/10.26434/chemrxiv.10288547
https://doi.org/10.26434/chemrxiv.10288547
Autor:
Alfredo Adán, Madeleine L. Stimpson, Victor Llorenç, M. Mesquida, Richard W J Lee, Andrew D. Dick, Gabriella Widmer, Sascha Fauser, Pamela Strassburger, Philippa J P Lait, Faye M. Drawnel, Blanca Molins, Maite Sainz de la Maza, David A. Copland
Publikováno v:
Translational Vision Science & Technology
Mesquida, M, Drawnel, F, Lait, P J, Copland, D A, Stimpson, M L, Llorenç, V, Sainz de la Maza, M, Adan, A, Widmer, G, Strassburger, P, Fauser, S, Dick, A D, Lee, R W J & Molins, B 2019, ' Modelling Macular Edema : The Effect of IL-6 and IL-6R Blockade on Human Blood-Retinal Barrier Integrity In Vitro ', Translational vision science & technology, vol. 8, no. 5, 32 . https://doi.org/10.1167/tvst.8.5.32
Mesquida, M, Drawnel, F, Lait, P J, Copland, D A, Stimpson, M L, Llorenç, V, Sainz de la Maza, M, Adan, A, Widmer, G, Strassburger, P, Fauser, S, Dick, A D, Lee, R W J & Molins, B 2019, ' Modelling Macular Edema : The Effect of IL-6 and IL-6R Blockade on Human Blood-Retinal Barrier Integrity In Vitro ', Translational vision science & technology, vol. 8, no. 5, 32 . https://doi.org/10.1167/tvst.8.5.32
Purpose: Macular edema (ME) is a leading cause of visual loss in a range of retinal diseases and despite the use of antivascular endothelial growth factor (anti-VEGF) agents, its successful treatment remains a major clinical challenge. Based on the i
Autor:
Jörg T Regula, Peter Lundh von Leithner, Richard Foxton, Veluchamy A Barathi, Gemmy Cheung Chui Ming, Sai Bo Bo Tun, Yeo Sia Wey, Daiju Iwata, Miroslav Dostalek, Jörg Moelleken, Kay G Stubenrauch, Everson Nogoceke, Gabriella Widmer, Pamela Strassburger, Michael J Koss, Christian Klein, David T Shima, Guido Hartmann
Publikováno v:
EMBO Molecular Medicine
Autor:
Everson Nogoceke, Kay Stubenrauch, Chui Ming Gemmy Cheung, Peter Lundh von Leithner, Sai Bo Bo Tun, Jörg Moelleken, Pamela Strassburger, Yeo Sia Wey, Daiju Iwata, David T. Shima, Gabriella Widmer, Jörg T. Regula, Veluchamy A Barathi, Michael Janusz Koss, Miroslav Dostálek, Christian Klein, Guido Hartmann, Richard Foxton
Publikováno v:
EMBO Molecular Medicine
Anti‐angiogenic therapies using biological molecules that neutralize vascular endothelial growth factor‐A (VEGF‐A) have revolutionized treatment of retinal vascular diseases including age‐related macular degeneration (AMD). This study reports