Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gabriella Szekely-Klepser"'
Autor:
Binodh DeSilva, Fabio Garofolo, Mario Rocci, Suzanne Martinez, Isabelle Dumont, France Landry, Catherine Dicaire, Gabriella Szekely-Klepser, Russell Weiner, Mark Arnold, Surendra Bansal, Kevin Bateman, Ronald Bauer, Brian Booth, Scott Davis, Sherri Dudal, Dominique Gouty, John Grundy, Sam Haidar, Roger Hayes, Mohammed Jemal, Surinder Kaur, Marian Kelley, Magnus Knutsson, Olivier Le Blaye, Jean Lee, Steve Lowes, Mark Ma, Toshinari Mitsuoka, João Tavares Neto, Robert Nicholson, Eric Ormsby, Jeffrey Sailstad, Lauren Stevenson, Daniel Tang, Jan Welink, CT Viswanathan, Laixin Wang, Eric Woolf, Eric Yang
Publikováno v:
Bioanalysis. 4:2213-2226
Over 400 professionals representing pharmaceutical companies, CROs, and multiple regulatory agencies participated in the 6th Workshop on Recent Issues in Bioanalysis (WRIB). Like the previous sessions, this event was in the format of a practical, foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cbabd89dab1ed5a31301fb38c914809
https://doi.org/10.4155/bio.12.205
https://doi.org/10.4155/bio.12.205
Publikováno v:
Biomedical Chromatography. 25:323-329
A simple plasma extraction method coupled with liquid chromatography–tandem mass spectrometry (LC/MS/MS) detection was developed and validated for the analysis of endogenous mevalonic acid (MVA), a biomarker indicative of the rate of cholesterol bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a626214bbf9b591b46c9d9983607fa
https://doi.org/10.1002/bmc.1449
https://doi.org/10.1002/bmc.1449
Autor:
Takeo Sakuma, Andrew Acheampong, Devin F. Welty, Carmai Seto, Gabriella Szekely-Klepser, Jinsong Ni, Robert Ellis, Hui Ouyang, Josh Rowe
Publikováno v:
Bioanalysis. 2:407-419
Background: The objective of this study was to evaluate the sensitivity requirement for LC–MS/MS as an analytical tool to characterize metabolites in plasma and urine at microdoses in rats and to investigate proportionality of metabolite exposure f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2933945f4674ba26fa5550f695bf8b
https://doi.org/10.4155/bio.10.10
https://doi.org/10.4155/bio.10.10
Autor:
Erick Kindt, Richard Brown, Scott Fountain, Kimberly Jane Wade, Dayna Woolson, Gabriella Szekely-Klepser
Publikováno v:
Journal of Chromatography B. 826:31-40
A novel skin tissue extraction method coupled with liquid chromatography-tandem mass spectrometry (LC/MS/MS) detection was developed and validated for the analysis of endogenous pyrrole-2,3,5-tricarboxylic acid (PTCA), a eumelanin specific biomarker,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c58eea436d019805885d057e2321d2d
https://doi.org/10.1016/j.jchromb.2005.08.002
https://doi.org/10.1016/j.jchromb.2005.08.002
Publikováno v:
Journal of Surfactants and Detergents. 8:263-269
The separation and detection properties of various ethoxylated polymers were investigated with atmospheric pressure ionization liquid chromatography/mass spectrometry (LC/MS). Interesting chromatographic elution behavior based on functionality was no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0ef1d3694f030fc2bee87f1e18bdcf8
https://doi.org/10.1007/s11743-005-0356-0
https://doi.org/10.1007/s11743-005-0356-0
Autor:
Erick Kindt, Gabriella Szekely‐Klepser
Publikováno v:
Encyclopedia of Drug Metabolism and Interactions
The goal of drug discovery and development is to find the right drug and to administer it at the right dose with the right frequency to the right patient. Biomarkers can be an invaluable tool to enable meeting this goal by confirming the efficacy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cfb619d2d81d1b7fe89452c7cbf26fb
https://doi.org/10.1002/9780470921920.edm111
https://doi.org/10.1002/9780470921920.edm111
Publikováno v:
Predictive Approaches in Drug Discovery and Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::904fd7ae86a58df626257020fc70d23c
https://doi.org/10.1002/9781118230275.ch2
https://doi.org/10.1002/9781118230275.ch2
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 641
Biomarkers play an increasingly important role for drug efficacy and safety evaluation in all stages of drug development. It is especially important to develop and validate sensitive and selective biomarkers for diseases where the onset of the diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::658245be67fb42d2ac3bbc4e37c12234
https://pubmed.ncbi.nlm.nih.gov/20407952
https://pubmed.ncbi.nlm.nih.gov/20407952
Publikováno v:
Methods in Molecular Biology ISBN: 9781607617105
Biomarkers play an increasingly important role for drug efficacy and safety evaluation in all stages of drug development. It is especially important to develop and validate sensitive and selective biomarkers for diseases where the onset of the diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c226aa792df444e367a7acc778eed1fd
https://doi.org/10.1007/978-1-60761-711-2_15
https://doi.org/10.1007/978-1-60761-711-2_15
Autor:
Jon A. Klover, Nalini Sadagopan, Yanhua Zhang, Gabriella Szekely-Klepser, Wenlin Li, Dawn Dufield, Christopher Lepsy
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 877(5-6)
An LC-MS/MS method was developed and validated to quantify endogenous cyclic guanosine 3',5'-monophosphate (cGMP) in human plasma. The LC-MS/MS and competitive enzyme immunoassay (EIA) assays were compared. cGMP concentrations of 20 human plasma samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c965214bf77e6403bd79d5031187c19
https://pubmed.ncbi.nlm.nih.gov/19179124
https://pubmed.ncbi.nlm.nih.gov/19179124